Expression of Caveolin-1 in tongue squamous cell carcinoma by quantum dots

Quantum dots (QDs) are a new class of fluorescent probes to detect biomarker expression. The role of caveolin-1 (Cav-1) in tongue squamous cell carcinoma (TSCC) is still unknown. This study aimed to investigate the expression profile of Cav-1 in carcinogenesis and development of TSCC by QDs immunofluorescence histochemistry (QDs-IHC) and discuss the relationship between the Cav-1 expression and the clinicopathological outcomes. QDs-IHC was used to detect Cav-1 expression in tissue microarrays including normal tongue mucosa (NTM; n=10), hyperplastic tongue mucosa (HTM; n=10), tongue pre-cancer lesions (TPL; n=15) and primary tongue squamous cell carcinoma (PTSCC; n=61). Correlations between the Cav-1 expression and clinicopathologic variables were evaluated statistically. Cells positive for Cav-1 were clearly detected and bright images were obtained in a fine, granular pattern at the cell membrane and cytoplasm using QDs-IHC. The rate of Cav-1 immunoreactivity increased progressively from NTM (0%), HTM (0%), TPL (36%) to PTSCC (74%). When compared with each other, there was statistical significance among PTSCC, TPL and NTM as well as among PTSCC, TPL and HTM. Moreover, Cav-1 expression level in PTSCC was correlated positively with clinical stage and histologic grade. QDs-IHC could accurately detect protein location in tongue mucosa. An increased expression of Cav-1 in the stepwise carcinogenesis from NTM, HTM, TPL to PTSCC suggested that Cav-1 might be an oncogene in the development of tongue squamous cell carcinoma

Cooperative inter-vehicle communication protocol with low cost differential GPS

This paper describes a cooperative MANET protocol dedicated to intelligent transport systems, named CIVIC (Communication Inter Véhicule Intelligente et Coopérative). The CIVIC protocol is an auto-configuration inter-vehicle communication protocol, which supports adhoc and infrastructure networks, contains reactive and proactive routing components, and adapts different wireless standards. It is a context-aware protocol reacting to vehicle status, road traffic, and geographic environment. It supports location-based communication. To improve the accuracy of GPS, it integrates a localization solution called LCD-GPS (Low Cost Differential GPS). It has been implemented and experimented on the LiveNode sensor developed by our lab. At the end of this paper, an application project MobiPlus is introduced

Modified yupingfeng formula for the treatment of stable chronic obstructive pulmonary disease: a systematic review of randomized controlled trials

Background: Chronic obstructive pulmonary disease (COPD), is a very  common disease of respiratory system. An increasing number of clinical  trials on Yupingfeng formula in the management of stable COPD have been performed. However, the evidence base for it remains unknown. This review aims at assessing the efficacy, and safety of modified Yupingfeng  formula in the treatment of stable COPD through a systematic review of all available randomized controlled trials. Materials and Methods: Literature retrieval was conducted using four English databases (CENTRAL, PubMed, EMBASE, and ISI Web of Science), and four Chinese databases (CBM, CNKI, VIP, and WANFANG), from respective inception to January 2013, and supplemented with a manual search. Review authors independently extracted the trial data, and assessed the quality of each trial. Methodological quality was assessed by Cochrane risk of bias and Jadad’s scale. The following outcomes were evaluated: (1) lung function; (2) 6-minute walk distance (6MWD); (3) effective rate; (4) serum levels of IgA, IgG and IgE; and (5) adverse events. Data were analyzed using STATA 12.0 software.Results: A total of nine studies involving 660, stable COPD patients were identified. Patients from all studies included in this review were randomized to receive Yupingfeng formula combined with Western medications in comparison with Western medications. In general, the methodological quality of the included trials was poor. The results of this systematic review indicates that, compared with Western medications alone, the use of Yupingfeng formula, if combined with Western medications could significantly improve FEV1 (WMD = 0.30L; 95%CI: 0.19, 0.42), FEV1/FVC ratio (SMD = 0.69; 95%CI: 0.48, 0.91), 6MWD (WMD = 31.73m; 95% CI: 19.29, 44.17), and effective rate (RR = 1.24; 95% CI: 1.10, 1.41), and increase the serum levels of IgA (WMD = 0.25; 95%CI: 0.16, 0.34) and IgG (WMD = 1.10; 95%CI: 0.53, 1.68), but no difference was found in the serum IgE levels (WMD = 0.47; 95%CI: －0.32, 1.27) between the two groups. No serious adverse events were reported.Conclusions: Within the limitations of this systematic review, we may conclude that compared with Western medications alone, Yupingfeng formula, when combined with Western medications can provide more benefits for patients with stable COPD, without any serious adverse reactions being identified. However, these benefits need to be further confirmed through high-quality prospective placebo-controlled trials that should be strictly conducted in accordance with methodological principles and procedures.Key words: Yupingfeng formula; chronic obstructive pulmonary disease; Systematic revie

Simulation research on molten steel flowing behavior in wide slab continuous casting mold

Research on the flowing behavior of molten steel in the continuous casting mold is the key to promote the smooth process of continuous casting and improve the quality of casting blanks. In this article, a three-dimensional solid model of 230 mm × l 600 mm is created based on actual wide slab mold, and analyze the influence of the casting speed, nozzle angle and immersion depth on the flowing behavior of molten steel. It is concluded that the suitable nozzle angle and immersion depth at a certain casting speed can provide theoretical support for continuous casting efficiently and the process optimization

Measurements of branching fractions for inclusive K0~/K0 and K*(892)+- decays of neutral and charged D mesons

Using the data sample of about 33 pb-1 collected at and around 3.773 GeV with the BES-II detector at the BEPC collider, we have studied inclusive K0~/K0 and K*(892)+- decays of D0 and D+ mesons. The branching fractions for the inclusive K0~/K0 and K*(892)- decays are measured to be BF(D0 to K0~/K0 X)=(47.6+-4.8+-3.0)%, BF(D+ to K0~/K0 X)=(60.5+-5.5+-3.3)%, BF(D0 to K*- X)=(15.3+- 8.3+- 1.9)% and BF(D+ to K*- X)=(5.7+- 5.2+- 0.7)%. The upper limits of the branching fractions for the inclusive K*(892)+ decays are set to be BF(D0 to K*+ X)<3.6% and BF(D+ to K*+ X) <20.3% at 90% confidence level

Direct Measurements of the Branching Fractions for Inclusive K±K^\pm and Inclusive Semileptonic Decays of D+D^+ and D0D^0 Mesons

With singly-tagged $\bar D$ samples selected from the data collected at and around 3.773 GeV with the BESII detector at the BEPC collider, we have measured the branching fractions for the inclusive $K^\pm$ decays of $D^+$ and $D^0$ mesons, which are $BF(D^+\to K^-X) = (24.7 \pm 1.3 \pm 1.2)$, $BF(D^+\to K^+X) = (6.1 \pm 0.9 \pm 0.4)$, $BF(D^0\to K^-X) = (57.8 \pm 1.6 \pm 3.2)$ and $BF(D^0\to K^+X) = (3.5 \pm 0.7 \pm 0.3)$, respectively. We have also measured the branching fractions for the inclusive semileptonic decays of $D^+$ and $D^0$ mesons to be $BF(D^+ \to e^+ X)=(15.2 \pm 0.9 \pm 0.8)$ and $BF(D^0 \to e^+ X) =(6.3 \pm 0.7 \pm 0.4)$. These yield the ratio of their partial widths to be $\Gamma(D^+ \to e^+X)/\Gamma(D^0 \to e^+X)=0.95 \pm 0.12 \pm 0.07$.Comment: 6 pages, 5 figure

Dipole-Quadrupole Theory of Surface Enhanced Infrared Absorption and Appearance of Forbidden Lines in the SEIRA Spectra of Symmetrical Molecules

The paper presents main aspects of the Dipole-Quadrupole theory of Surface Enhanced Infrared Absorption (SEIRA). It is pointed out the possibility of appearance of the lines, caused by totally symmetric vibrations transforming after the unit irreducible representation, which are forbidden in usual infrared absorption spectra in molecules with sufficiently high symmetry. Observation of such lines in the SEIRA spectra of diprotonated and ethylene, adsorbed on and on mordenites is pointed out. The results well agree with our ideas about surface enhanced optical processes, based on the conception of a strong quadrupole light-molecule interaction, which allows us to develop the SERS and SEHRS theories.Comment: 15 pages,3 figures, 1 tabl

Measurement of \psip Radiative Decays

Using 14 million psi(2S) events accumulated at the BESII detector, we report first measurements of branching fractions or upper limits for psi(2S) decays into gamma ppbar, gamma 2(pi^+pi^-), gamma K_s K^-pi^++c.c., gamma K^+ K^- pi^+pi^-, gamma K^{*0} K^- pi^+ +c.c., gamma K^{*0}\bar K^{*0}, gamma pi^+pi^- p pbar, gamma 2(K^+K^-), gamma 3(pi^+pi^-), and gamma 2(pi^+pi^-)K^+K^- with the invariant mass of hadrons below 2.9GeV/c^2. We also report branching fractions of psi(2S) decays into 2(pi^+pi^-) pi^0, omega pi^+pi^-, omega f_2(1270), b_1^\pm pi^\mp, and pi^0 2(pi^+pi^-) K^+K^-.Comment: 5 pages, 4 figure

Understanding IoT Security Through the Data Crystal Ball: Where We Are Now and Where We Are Going To Be

Inspired by the boom of the consumer IoT market, many device manufacturers, new start-up companies and technology behemoths have jumped into the space. Indeed, in a span of less than 5 years, we have experienced the manifestation of an array of solutions for the smart home, smart cities and even smart cars. Unfortunately, the exciting utility and rapid marketization of IoTs, come at the expense of privacy and security. Online and industry reports, and academic work have revealed a number of attacks on IoT systems, resulting in privacy leakage, property loss and even large-scale availability problems on some of the most influential Internet services (e.g. Netflix, Twitter). To mitigate such threats, a few new solutions have been proposed. However, it is still less clear what are the impacts they can have on the IoT ecosystem. In this work, we aim to perform a comprehensive study on reported attacks and defenses in the realm of IoTs aiming to find out what we know, where the current studies fall short and how to move forward. To this end, we first build a toolkit that searches through massive amount of online data using semantic analysis to identify over 3000 IoT-related articles (papers, reports and news). Further, by clustering such collected data using machine learning technologies, we are able to compare academic views with the findings from industry and other sources, in an attempt to understand the gaps between them, the trend of the IoT security risks and new problems that need further attention. We systemize this process, by proposing a taxonomy for the IoT ecosystem and organizing IoT security into five problem areas. We use this taxonomy as a beacon to assess each IoT work across a number of properties we define. Our assessment reveals that despite the acknowledged and growing concerns on IoT from both industry and academia, relevant security and privacy problems are far from solved. We discuss how each proposed solution can be applied to a problem area and highlight their strengths, assumptions and constraints. We stress the need for a security framework for IoT vendors and discuss the trend of shifting security liability to external or centralized entities. We also identify open research problems and provide suggestions towards a secure IoT ecosystem