Human oesophageal adenocarcinoma cell lines JROECL 47 and JROECL 50 are admixtures of the human colon carcinoma cell line HCT 116

In two recently described human oesophageal adenocarcinoma cell lines JROECL 47 and JROECL 50, derived from one tumour, we detected identical E-cadherin and β-catenin gene mutations as in colon carcinoma cell line HCT 116. We demonstrate by HLA-typing, mutation analysis and microsatellite analysis that cell lines JROECL 47 and JROECL 50 are admixtures of the human colon adenocarcinoma cell line HCT 116. © 2000 Cancer Research Campaig

High-Mass X-ray Binaries and the Spiral Structure of the Host Galaxy

We investigate the manifestation of the spiral structure in the distribution of high-mass X-ray binaries (HMXBs) over the host galaxy. We construct the simple kinematic model. It shows that the HMXBs should be displaced relative to the spiral structure observed in such traditional star formation rate indicators as the Halpha and FIR emissions because of their finite lifetimes. Using Chandra observations of M51, we have studied the distribution of X-ray sources relative to the spiral arms of this galaxy observed in Halpha. Based on K-band data and background source number counts, we have separated the contributions from high-mass and low-mass X-ray binaries and active galactic nuclei. In agreement with model predictions, the distribution of HMXBs is wider than that of bright HII regions concentrated in the region of ongoing star formation. However, the statistical significance of this result is low, as is the significance of the concentration of the total population of X-ray sources to the spiral arms. We also predict the distribution of HMXBs in our Galaxy in Galactic longitude. The distribution depends on the mean HMXB age and can differ significantly from the distributions of such young objects as ultracompact HII regions.Comment: 18 pages, 6 figures; Astronomy Letters, Vol. 33, No. 5, 2007, pp. 299-30

Star Formation Thresholds in Galactic Disks

We report the first results of a detailed study of the star formation law in a sample of 32 nearby spiral galaxies with well-measured rotation curves, HI and H$_2$ (as traced by CO) surface density profiles, and new \Ha CCD photometry. Our results strongly support the view that the formation of gravitationally bound interstellar clouds regulates the onset of widespread star formation -- at least in the outer regions of galactic disks.Comment: Will appear in July 1 ApJ. Abbreviated abstract. Postscript version available at http://www.astro.caltech.edu/~clm

The LBT Panoramic View on the Recent Star-Formation Activity in IC2574

We present deep imaging of the star-forming dwarf galaxy IC2574 in the M81 group taken with the Large Binocular Telescope in order to study in detail the recent star-formation history of this galaxy and to constrain the stellar feedback on its HI gas. We identify the star-forming areas in the galaxy by removing a smooth disk component from the optical images. We construct pixel-by-pixel maps of stellar age and stellar mass surface density in these regions by comparing their observed colors with simple stellar populations synthesized with STARBURST99. We find that an older burst occurred about 100 Myr ago within the inner 4 kpc and that a younger burst happened in the last 10 Myr mostly at galactocentric radii between 4 and 8 kpc. We analyze the stellar populations residing in the known HI holes of IC2574. Our results indicate that, even at the remarkable photometric depth of the LBT data, there is no clear one-to-one association between the observed HI holes and the most recent bursts of star formation in IC2574. The stellar populations formed during the younger burst are usually located at the periphery of the HI holes and are seen to be younger than the holes dynamical age. The kinetic energy of the holes expansion is found to be on average 10% of the total stellar energy released by the stellar winds and supernova explosions of the young stellar populations within the holes. With the help of control apertures distributed across the galaxy we estimate that the kinetic energy stored in the HI gas in the form of its local velocity dispersion is about 35% of the total stellar energy.Comment: 16 pages, 14 figures, accepted for publication in Ap

CO(4-3) and dust emission in two powerful high-z radio galaxies, and CO lines at high redshifts

We report the detection of sub-mm emission from dust at 850 microns and of the 12CO J=4-3 line in the two distant powerful radio galaxies 4C 60.07 (z=3.79) and 6C 1909+722 (z=3.53). In the case of 4C 60.07 the dust emission is also detected at 1.25 mm. The estimated molecular gas masses are large, of the order of ~(0.5-1)x10^{11} Solar. The large FIR luminosities (L_fir ~ 10^{13} Solar) suggest that we are witnessing two major starburst phenomena, while the observed large velocity widths (FWHM > 500 km/sec) are characteristic of mergers. In the case of 4C 60.07 the CO emission extends over ~30 kpc and spans a velocity range of >1000 km/sec. It consists of two distinct features with FWHM of >= 550 km/sec and ~150 km/sec and line centers separated by >=700 km/sec The least massive of these components is probably very gas-rich with potentially >=60% of its dynamical mass in the form of molecular gas. The extraordinary morphology of the CO emission in this object suggests that it is not just a scaled-up version of a local Ultra Luminous Infrared Galaxy, and it may be a formative stage of the elliptical host of the residing radio-loud AGN. Finally we briefly explore the effects of the wide range of gas excitation conditions expected for starburst environments on the luminosity of high-J CO lines. We conclude that in unlensed objects, CO (J+1-->J), J+1>3 lines can be significantly weak with respect to CO J=1-0 and this can hinder their detection even in the presence of substantial molecular gas masses.Comment: 34 pages, 5 figures, accepted for publication in The Astrophysical Journa

Prognostic factors for survival in patients with advanced oesophageal cancer treated with cisplatin-based combination chemotherapy

The objective of this study was to identify prognostic factors for survival in patients with advanced oesophageal cancer, who are treated with cisplatin-based combination chemotherapy. We analysed the baseline characteristics of 350 patients who were treated in six consecutive prospective trials with one of the following regimens: cisplatin/etoposide, cisplatin/etoposide/5-fluorouracil, cisplatin/paclitaxel (weekly) and cisplatin/paclitaxel (biweekly). Predictive factors in univariate analyses were further evaluated using multivariate analysis (Cox regression). The median survival of all patients was 9 months. The 1, 2 and 5-year survival rates were 33, 12 and 4%, respectively. The main prognostic factors were found to be WHO performance status (0 or 1 vs 2), lactate dehydrogenase (normal vs elevated), extent of disease (limited disease defined as locoregional irresectable disease or lymph node metastases confined to either the supraclavicular or celiac region vs extensively disseminated disease) in addition to the type of treatment (weekly or biweekly cisplatin/paclitaxel regimen vs 4-weekly cisplatin/etoposide with or without 5-fluorouracil). Although weight loss, liver metastases and alkaline phosphatase were significant prognostic factors in univariate analyses, these factors lost their significance in multivariate analyses. The median survival for patients without any risk factors was 12 months, compared to only 4 months in patients with WHO 2 plus elevated LDH and extensive disease. The performance status, extent of disease, LDH and the addition of paclitaxel to cisplatin are independent prognostic factors in patients with advanced oesophageal cancer, who are treated with cisplatin-based combination chemotherapy