Representing narrative and testimonial knowledge in sense-making software for crime analysis.

In the AVERs sense-making tool for crime analysis different types of information are represented in different ways. More precisely, narrative knowledge is represented in an explanatory direction and testimonial knowledge in an indicative direction. This paper shows that this distinction agrees with the preference of potential users and reduces the number of interpretation errors made by them

Representing narrative and testimonial knowledge in sense-making software for crime analysis.

Abstract. In the AVERs sense-making tool for crime analysis different types of information are represented in different ways. More precisely, narrative knowledge is represented in an explanatory direction and testimonial knowledge in an indicative direction. This paper shows that this distinction agrees with the preference of potential users and reduces the number of interpretation errors made by them

VLT observations of GRB 990510 and its environment

We present BVRI photometry and spectrophotometry of GRB990510 obtained with the ESO VLT/Antu telescope during the late decline phase. Between days 8 and 29 after the burst, the afterglow faded from R=24.2 to ~26.4. The spectral flux distribution and the light curve support the interpretation of the afterglow as synchrotron emission from a jet. The light curve is consistent with the optical transient alone but an underlying SN with maximum brightness R>27.4 or a galaxy with R>27.6 (3-sigma upper limits) cannot be ruled out. To a 5-sigma detection threshold of R=26.1, no galaxy is found within 6'' of the transient. A very blue V~24.5 extended object which may qualify as a starburst galaxy is located 12'' SE, but at unknown redshift.Comment: 5 pages A&A Latex, accepted for publication in A&A Letter

Integrate and Fire Neural Networks, Piecewise Contractive Maps and Limit Cycles

We study the global dynamics of integrate and fire neural networks composed of an arbitrary number of identical neurons interacting by inhibition and excitation. We prove that if the interactions are strong enough, then the support of the stable asymptotic dynamics consists of limit cycles. We also find sufficient conditions for the synchronization of networks containing excitatory neurons. The proofs are based on the analysis of the equivalent dynamics of a piecewise continuous Poincar\'e map associated to the system. We show that for strong interactions the Poincar\'e map is piecewise contractive. Using this contraction property, we prove that there exist a countable number of limit cycles attracting all the orbits dropping into the stable subset of the phase space. This result applies not only to the Poincar\'e map under study, but also to a wide class of general n-dimensional piecewise contractive maps.Comment: 46 pages. In this version we added many comments suggested by the referees all along the paper, we changed the introduction and the section containing the conclusions. The final version will appear in Journal of Mathematical Biology of SPRINGER and will be available at http://www.springerlink.com/content/0303-681

Cardiac Function and Architecture Are Maintained in a Model of Cardiorestricted Overexpression of the Prorenin-Renin Receptor

The (pro)renin-renin receptor, (P)RR has been claimed to be a novel element of the renin-angiotensin system (RAS). The function of (P)RR has been widely studied in renal and vascular pathology but the cardio-specific function of (P)RR has not been studied in detail. We therefore generated a transgenic mouse (Tg) with cardio-restricted (P)RR overexpression driven by the alpha-MHC promotor. The mRNA expression of (P)RR was ∼170-fold higher (P<0.001) and protein expression ∼5-fold higher (P<0.001) in hearts of Tg mice as compared to non-transgenic (wild type, Wt) littermates. This level of overexpression was not associated with spontaneous cardiac morphological or functional abnormalities in Tg mice. To assess whether (P)RR could play a role in cardiac hypertrophy, we infused ISO for 28 days, but this caused an equal degree of cardiac hypertrophy and fibrosis in Wt and Tg mice. In addition, ischemia-reperfusion injury was performed in Langendorff perfused isolated mouse hearts. We did not observe differences in parameters of cardiac function or damage between Wt and Tg mouse hearts under these conditions. Finally, we explored whether the hypoxia sensing response would be modulated by (P)RR using HeLa cells with and without (P)RR overexpression. We did not establish any effect of (P)RR on expression of genes associated with the hypoxic response. These results demonstrate that cardio-specific overexpression of (P)RR does not provoke phenotypical differences in the heart, and does not affect the hearts’ response to stress and injury. It is concluded that increased myocardial (P)RR expression is unlikely to have a major role in pathological cardiac remodeling

The Supreme Court and the American Civil Liberties Union\u27s Colorblind Protection of Cross Burning in First Amendment Jurisprudence Legitimates White Supremacy

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