Double-EIT ground-state laser cooling without blue-sideband heating

We discuss a laser cooling scheme for trapped atoms or ions which is based on double electromagnetically induced transparency (EIT) and makes use of a four-level atom in tripod configuration. The additional fourth atomic state is coupled by a strong coupling laser field to the usual three-level setup of single-EIT cooling. This effectively allows to create two EIT structures in the absorption spectrum of the system to be cooled, which may be controlled by the coupling laser field parameters to cancel both the carrier- and the blue-sideband excitations. In leading order of the Lamb-Dicke expansion, this suppresses all heating processes. As a consequence, the double-EIT scheme can be used to lower the cooling limit by almost two powers of the Lamb-Dicke parameter as compared to single-EIT cooling.Comment: 7 pages, 3 figure

Dynamical invariants and nonadiabatic geometric phases in open quantum systems

We introduce an operational framework to analyze non-adiabatic Abelian and non-Abelian, cyclic and non-cyclic, geometric phases in open quantum systems. In order to remove the adiabaticity condition, we generalize the theory of dynamical invariants to the context of open systems evolving under arbitrary convolutionless master equations. Geometric phases are then defined through the Jordan canonical form of the dynamical invariant associated with the super-operator that governs the master equation. As a by-product, we provide a sufficient condition for the robustness of the phase against a given decohering process. We illustrate our results by considering a two-level system in a Markovian interaction with the environment, where we show that the non-adiabatic geometric phase acquired by the system can be constructed in such a way that it is robust against both dephasing and spontaneous emission.Comment: 9 pages, 3 figures. v2: minor corrections and subsection IV.D added. Published versio

Stimulated Raman adiabatic passage in a multi-level atom

We present a general formalism for describing stimulated Raman adiabatic passage in a multi-level atom. The atom is assumed to have two ground state manifolds a and b and an excited state manifold e, and the adiabatic passage is carried out by resonantly driving the a-e and b-e transitions with time-dependent fields. Our formalism gives a complete description of the adiabatic passage process, and can be applied to systems with arbitrary numbers of degenerate states in each manifold and arbitrary couplings of the a-e and b-e transitions. We illustrate the formalism by applying it to both a simple toy model and to adiabatic passage in the Cesium atom.Comment: 14 pages, 2 figure

Stimulated Raman Adiabatic Passage (STIRAP) Among Degenerate-Level Manifolds

We examine the conditions needed to accomplish stimulated Raman adiabatic passage (STIRAP) when the three levels (g, e and f) are degenerate, with arbitrary couplings contributing to the pump-pulse interaction (g - e) and to the Stokes-pulse interaction (e-f). We show that in general a sufficient condition for complete population removal from the g set of degenerate states for arbitrary, pure or mixed, initial state is that the degeneracies should not decrease along the sequence g, e and f. We show that when this condition holds it is possible to achieve the degenerate counterpart of conventional STIRAP, whereby adiabatic passage produces complete population transfer. Indeed, the system is equivalent to a set of independent three-state systems, in each of which a STIRAP procedure can be implemented. We describe a scheme of unitary transformations that produces this result. We also examine the cases when this degeneracy constraint does not hold, and show what can be accomplished in those cases. For example, for angular momentum states when the degeneracy of the g and f levels is less than that of the e level we show how a special choice for the pulse polarizations and phases can produce complete removal of population from the g set. Our scheme can be a powerful tool for coherent control in degenerate systems, because of its robustness when selective addressing of the states is not required or impossible. We illustrate the analysis with several analytically solvable examples, in which the degeneracies originate from angular momentum orientation, as expressed by magnetic sublevels.Comment: 21 pages, 17 figure

Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats

BACKGROUND: We are investigating a double transgenic rat (dTGR) model, in which rats transgenic for the human angiotensinogen and renin genes are crossed. These rats develop moderately severe hypertension but die of end-organ cardiac and renal damage by week 7. The heart shows necrosis and fibrosis, whereas the kidneys resemble the hemolytic-uremic syndrome vasculopathy. Surface adhesion molecules (ICAM-1 and VCAM-1) are expressed early on the endothelium, while the corresponding ligands are found on circulating leukocytes. Leukocyte infiltration in the vascular wall accompanies PAI-1, MCP-1, iNOS and Tissue Factor expression. Furthermore we show evidence that Ang II causes the upregulation of NF-{kappa}B in our model. METHODS: We started PDTC-treatment on four weeks old dTGR (200 mg/kg sc) and age-matched SD rats. Blood-pressure- and albuminuria- measurements were monitored during the treatment period (four weeks). The seven weeks old animals were killed, hearts and kidneys were isolated and used for immunohistochemical-and electromobility shift assay analysis. RESULTS: Chronic treatment with the antioxidant PDTC decreased blood pressure (162 plus minus 8 vs. 190 plus minus 7 mm Hg, p = 0.02). Cardiac hypertrophy index was significantly reduced (4.90 plus minus 0.1 vs. 5.77 plus minus 0.1 mg/g, p < 0.001) compared to dTGR. PDTC reduced 24 h albuminuria by 85 % (2.7 plus minus 0.5 vs. 18.0 plus minus 3.4 mg/d, p < 0.001) and prevented death significantly. Vascular injury was ameliorated in small renal and cardiac vessels. PDTC inhibited NF-{kappa}B binding activity in heart and kidney. Immunohistochemical analysis shows increased expression of the p65 NF-{kappa}B subunit in the endothelium, smooth muscles cells of damaged small vessels, infiltrated cells, glomeruli, tubuli and collecting ducts of dTGR. PDTC markedly reduced the immunoreactivity of p65. CONCLUSION: Our data show that inhibition of NF-{kappa}B by PDTC markedly reduces inflammation, iNOS expression in the dTGR most likely leading to decreased cytotoxicity, and cell proliferation. Thus, NF-{kappa}B activation plays an important role in ANG II-induced end-organ damage

Adiabatic creation of coherent superposition states via multiple intermediate states

We consider an adiabatic population transfer process that resembles the well established stimulated Raman adiabatic passage (STIRAP). In our system, the states have nonzero angular momentums $J$, therefore, the coupling laser fields induce transitions among the magnetic sublevels of the states. In particular, we discuss the possibility of creating coherent superposition states in a system with coupling pattern $J=0\Leftrightarrow J=1$ and $J=1\Leftrightarrow J=2$. Initially, the system is in the J=0 state. We show that by two delayed, overlapping laser pulses it is possible to create any final superposition state of the magnetic sublevels $|2,-2>$, $|2,0>$, $|2,+2>$. Moreover, we find that the relative phases of the applied pulses influence not only the phases of the final superposition state but the probability amplitudes as well. We show that if we fix the shape and the time-delay between the pulses, the final state space can be entirely covered by varying the polarizations and relative phases of the two pulses. Performing numerical simulations we find that our transfer process is nearly adiabatic for the whole parameter set.Comment: 7 pages, 10 figure

Adiabatic population transfer via multiple intermediate states

This paper discusses a generalization of stimulated Raman adiabatic passage (STIRAP) in which the single intermediate state is replaced by $N$ intermediate states. Each of these states is connected to the initial state \state{i} with a coupling proportional to the pump pulse and to the final state \state{f} with a coupling proportional to the Stokes pulse, thus forming a parallel multi-$\Lambda$ system. It is shown that the dark (trapped) state exists only when the ratio between each pump coupling and the respective Stokes coupling is the same for all intermediate states. We derive the conditions for existence of a more general adiabatic-transfer state which includes transient contributions from the intermediate states but still transfers the population from state \state{i} to state \state{f} in the adiabatic limit. We present various numerical examples for success and failure of multi-$\Lambda$ STIRAP which illustrate the analytic predictions. Our results suggest that in the general case of arbitrary couplings, it is most appropriate to tune the pump and Stokes lasers either just below or just above all intermediate states.Comment: 14 pages, two-column revtex style, 10 figure

DNA copy number changes in young gastric cancer patients with special reference to chromosome 19

Only a few cytogenetic and genetic studies have been performed in gastric cancer patients in young age groups. In the present study we used the comparative genomic hybridisation (CGH) method to characterise frequent DNA copy number changes in 22 gastric cancer patients of 45 years or younger and three gastric cancer cell lines established from patients younger than 45 years. Analysis of DNA copy number changes revealed frequent DNA copy number increases at chromosomes 17q (52%), 19q (68%) and 20q (64%). To confirm the CGH results and to characterise the amplicon region on the most frequently amplified chromosome, chromosome 19, we carried out fluorescence in situ hybridisation (FISH) analysis and Southern blot analysis. Fluorescence in situ hybridisation with the bacterial artificial chromosome (BAC) clone mapped to 19q12 indicated a copy number increase in all eight tumour specimens studied. Southern blot analysis of six tumour specimens and three tumour cell lines, with five probes mapped to the 19q12-13.2 region, suggested cyclin E to be one of the candidate target genes in the 19q region for gastric cancer tumorigenesis. Cyclin E protein overexpression was verified in tumours with amplification on chromosome 19. Further studies are required to investigate the biological and clinical significance of 19q amplicon and cyclin E upregulation in gastric cancer of young patient

Considerations in Building and Fielding MPDV

Author Institution: National Security Technologies, LLCSlides presented at the 6th Annual Photonic Doppler Velocimetry (PDV) Workshop held at Lawrence Livermore National Laboratory, Livermore, California, November 3-4, 2011

Технологические решения для строительства разведочной вертикальной скважины глубиной 2650 метров на нефтяном месторождении (Тюменская область)

Объектом исследования является разведочная вертикальная скважина глубиной 2650 метров на нефтяном месторождении (Тюменская область). Целью работы является – спроектировать технологическое решения для бурения вертикальной разведочной скважины, геолого-технический наряд, компоновки низа бурильной колонны, интервалы бурении и спуск обсадных колонн, интервалы цементирования.The object of the study is a vertical exploratory well with a depth of 2,650 meters in an oil field (Tyumen Oblast). The aim of the work is to design technological solutions for drilling a vertical exploration well, geological and technical outfit, layouts of the bottom of the drill string, drilling intervals and running of the casing strings, cementing intervals