Review of CCAFS Scaling Activities

This review was commissioned by CCAFS Learning Platform for Partnerships and Capacity Building for Scaling Climate Smart Agriculture, with the aim to reflect on CCAFS project portfolio to highlight good practices and gaps in implementation of CCAFS Scaling Activities. The review was undertaken with a systemic approach, using the concepts of design thinking and system thinking throughout its methodology and analysis. 21 practitioners throughout CCAFS regional, flagship and learning platform portfolios were interviewed between March and May 2019. The results are presented in a way that allows CCAFS to identify areas to deepen systematically upon; areas for CCAFS’s further strategic or conceptual support, and areas that require more research by CCAFS. The systemic analysis shows that CCAFS has the potential to consciously transform into a learning organization and an innovation environment, thereby fostering and increasing its performance, relevance and overall impact in changing and challenging circumstances. The results were discussed and validated with the CCAFS Core Team (CT) in the frame of a CCAFS CT Workshop on Scaling on 15th May in Madrid. In open learning formats, the CT prioritized its next step. The review report further contains a set of recommendations, derived from both the review and the CT Workshop on Scaling, which shall help CCAFS to transform into both a learning organization and an innovation environment

The Scaling Mindset – Shifting from Problems to Solutions. Insights from the Review of CCAFS Scaling Activities, 2019

In the frame of the review of CCAFS scaling activities in 2019, 21 project leaders and –implementers were interviewed about their scaling processes, touching a series of aspects that had been identified as crucial and/or critical by earlier research. Results were analysed with a systemic approach, to draw organisational learnings. The findings were validated with CCAFS core team during their Scaling Workshop in Madrid, May 2019, in which the Core Team also prioritized its programmatic areas of response. This working paper captures the main insights and learnings from both the interviews on project level, followed by the results’ analysis. It then summarized the Core Team workshop’s main discussion points and shortly outlines the programmatic areas of response that CCAFS identified. The learnings and insights on the realities of scaling agricultural innovations presented in this working paper can provide a rich basis for further synthesis and/or deeper research on the different aspects of innovation development and scaling

CEO Hubris and Firm Pollution: A Tricky Relationship

Abstract: This article comments on the recent study “CEO hubris and firm pollution: state and market contingencies in a transitional economy” of Zhang et al. (J Bus Ethics 161(2):459–478, 2020) in this journal. We very much appreciate the valuable initiative of Zhang et al. to study the potential effect of CEO characteristics on corporate pollution. At the same time, we are concerned with the authors’ interpretation of the regression results and their operationalization of CEO hubris. We hope to contribute to the literature on managerial hubris in two ways. First, we repair the authors’ inferences and conclusions about the actual effect of CEO hubris on firm pollution with respect to their conflicting regression results. Second, we unpack and clarify the authors’ vulnerable operationalization of CEO hubris. We hope to stimulate more research on (1) the (tricky) relationship between CEO hubris and firm pollution, and (2) managerial hubris more generally through a more rigorous operationalization and measurement of hubris

Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma

Neuroblastoma is an embryonal malignancy of the sympathetic nervous system. Spontaneous regression and differentiation of neuroblastoma is observed in a subset of patients, and has been suggested to represent delayed activation of physiologic molecular programs of fetal neuroblasts. Homeobox genes constitute an important family of transcription factors, which play a fundamental role in morphogenesis and cell differentiation during embryogenesis. In this study, we demonstrate that expression of the majority of the human HOX class I homeobox genes is significantly associated with clinical covariates in neuroblastoma using microarray expression data of 649 primary tumors. Moreover, a HOX gene expression-based classifier predicted neuroblastoma patient outcome independently of age, stage and MYCN amplification status. Among all HOX genes, HOXC9 expression was most prominently associated with favorable prognostic markers. Most notably, elevated HOXC9 expression was significantly associated with spontaneous regression in infant neuroblastoma. Re-expression of HOXC9 in three neuroblastoma cell lines led to a significant reduction in cell viability, and abrogated tumor growth almost completely in neuroblastoma xenografts. Neuroblastoma growth arrest was related to the induction of programmed cell death, as indicated by an increase in the sub-G1 fraction and translocation of phosphatidylserine to the outer membrane. Programmed cell death was associated with the release of cytochrome c from the mitochondria into the cytosol and activation of the intrinsic cascade of caspases, indicating that HOXC9 re-expression triggers the intrinsic apoptotic pathway. Collectively, our results show a strong prognostic impact of HOX gene expression in neuroblastoma, and may point towards a role of Hox-C9 in neuroblastoma spontaneous regression

Scaling agricultural innovations – How to manage institutional change? Key messages from the CGIAR++ Scaling Workshop, Hanoi 2018

In the occasion of the Conference on Scaling in Hanoi, November 2018, researchers of nine CGIAR++ centers and partners came together in a Workshop on Scaling, to explore ways for institutionalizing scaling efforts in their respective organizations. The key messages summarized in this Info Note shall help the wider scaling community – as individuals or organizations - to embrace and manage institutional change

The why, what, who and how of scaling agricultural innovations: Key messages from the CCAFS SEA and cross-CRP Scaling Conference, Hanoi 2018

The brief discusses the key messages that transpired during the Conference on Scaling held on 29─30 November 2018 at the Melia Hotel in Hanoi, hosted by CCAFS SEA, co-hosted by ACIAR and GIZ, and funded by a CCAFS Small Grant Cross-CRP Networking. The conference main points include: scaling up agricultural innovations takes place in complex systems of agricultural transformation; and sustainable scaling should build into “sustainable change at scale”

Fluctuations of elastic interfaces in fluids: Theory and simulation

We study the dynamics of elastic interfaces-membranes-immersed in thermally excited fluids. The work contains three components: the development of a numerical method, a purely theoretical approach, and numerical simulation. In developing a numerical method, we first discuss the dynamical coupling between the interface and the surrounding fluids. An argument is then presented that generalizes the single-relaxation time lattice-Boltzmann method for the simulation of hydrodynamic interfaces to include the elastic properties of the boundary. The implementation of the new method is outlined and it is tested by simulating the static behavior of spherical bubbles and the dynamics of bending waves. By means of the fluctuation-dissipation theorem we recover analytically the equilibrium frequency power spectrum of thermally fluctuating membranes and the correlation function of the excitations. Also, the non-equilibrium scaling properties of the membrane roughening are deduced, leading us to formulate a scaling law describing the interface growth, W^2(L,T)=L^3 g[t/L^(5/2)], where W, L and T are the width of the interface, the linear size of the system and the temperature respectively, and g is a scaling function. Finally, the phenomenology of thermally fluctuating membranes is simulated and the frequency power spectrum is recovered, confirming the decay of the correlation function of the fluctuations. As a further numerical study of fluctuating elastic interfaces, the non-equilibrium regime is reproduced by initializing the system as an interface immersed in thermally pre-excited fluids.Comment: 15 pages, 11 figure