144 research outputs found
Statistical mechanics of lossy data compression using a non-monotonic perceptron
The performance of a lossy data compression scheme for uniformly biased
Boolean messages is investigated via methods of statistical mechanics. Inspired
by a formal similarity to the storage capacity problem in the research of
neural networks, we utilize a perceptron of which the transfer function is
appropriately designed in order to compress and decode the messages. Employing
the replica method, we analytically show that our scheme can achieve the
optimal performance known in the framework of lossy compression in most cases
when the code length becomes infinity. The validity of the obtained results is
numerically confirmed.Comment: 9 pages, 5 figures, Physical Review
Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in severe combined immunodeficient mice
Division of Medical Oncology and Surgical Oncolog
Novel dual targeting strategy with vandetanib induces tumor cell apoptosis and inhibits angiogenesis in malignant pleural mesothelioma cells expressing RET oncogenic rearrangement
Division of Medical Oncology and Surgical Oncolog
Lysophospahatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2
Division of Medical Oncology and Surgical Oncolog
Terahertz Faraday and Kerr rotation spectroscopy of BiSb films in high magnetic fields up to 30 Tesla
We report results of terahertz Faraday and Kerr rotation spectroscopy
measurements on thin films of , an alloy system
that exhibits a semimetal-to-topological-insulator transition as the Sb
composition increases. By using a single-shot time-domain terahertz
spectroscopy setup combined with a table-top pulsed mini-coil magnet, we
conducted measurements in magnetic fields up to 30~T, observing distinctly
different behaviors between semimetallic () and topological insulator
() samples. Faraday and Kerr rotation spectra for the semimetallic
films showed a pronounced dip that blue-shifted with the magnetic field,
whereas spectra for the topological insulator films were positive and
featureless, increasing in amplitude with increasing magnetic field and
eventually saturating at high fields (20~T). Ellipticity spectra for the
semimetallic films showed resonances, whereas the topological insulator films
showed no detectable ellipticity. To explain these observations, we developed a
theoretical model based on realistic band parameters and the Kubo formula for
calculating the optical conductivity of Landau-quantized charge carriers. Our
calculations quantitatively reproduced all experimental features, establishing
that the Faraday and Kerr signals in the semimetallic films predominantly arise
from bulk hole cyclotron resonances while the signals in the topological
insulator films represent combined effects of surface carriers originating from
multiple electron and hole pockets. These results demonstrate that the use of
high magnetic fields in terahertz magnetopolarimetry, combined with detailed
electronic structure and conductivity calculations, allows us to unambiguously
identify and quantitatively determine unique contributions from different
species of carriers of topological and nontopological nature in
BiSb.Comment: 17 pages, 22 figure
AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
A novel EGFR-tyrosine kinase inhibitor (TKI), osimertinib, has marked efficacy in patients with EGFR-mutated lung cancer. However, some patients show intrinsic resistance and an insufficient response to osimertinib. This study showed that osimertinib stimulated AXL by inhibiting a negative feedback loop. Activated AXL was associated with EGFR and HER3 in maintaining cell survival and inducing the emergence of cells tolerant to osimertinib. AXL inhibition reduced the viability of EGFR-mutated lung cancer cells overexpressing AXL that were exposed to osimertinib. The addition of an AXL inhibitor during either the initial or tolerant phases reduced tumor size and delayed tumor re-growth compared to osimertinib alone. AXL was highly expressed in clinical specimens of EGFR-mutated lung cancers and its high expression was associated with a low response rate to EGFR-TKI. These results indicated pivotal roles for AXL and its inhibition in the intrinsic resistance to osimertinib and the emergence of osimertinib-tolerant cells
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