Pregnancy outcomes in a malaria-exposed Malian cohort of women of child-bearing age

In Sub-Saharan Africa, malaria continues to be associated with adverse pregnancy outcomes including stillbirth, early neonatal death, preterm delivery, and low birth weight. Current preventive measures are insufficient and new interventions are urgently needed. However, before such interventions can be tested in pregnant women, background information on pregnancy outcomes in this target population must be collected. We conducted an observational study in Ouélessébougou, Mali, a malaria-endemic area where first antenatal visit commonly occurs during the second trimester of pregnancy, hindering calculation of miscarriage rate in the population. To accurately determine the rate of miscarriage, 799 non-pregnant women of child-bearing age were enrolled and surveyed via monthly follow up visits that included pregnancy tests. Out of 505 women that completed the study, 364 became pregnant and 358 pregnancies were analyzed: 43 (12%) resulted in miscarriage, 28 (65.1%) occurred during the first trimester of pregnancy. We also determined rates of stillbirth, neonatal death, preterm delivery, and small for gestational age. The results showed high rate of miscarriage during the first trimester and established a basis to evaluate new interventions to prevent pregnancy malaria. This survey design enabled identification of first trimester miscarriages that are often missed by studies conducted in antenatal clinics.Clinical trial registration[https://clinicaltrials.gov/], identifier [NCT0297 4608]

The physiological responses of cacao to the environment and the implications for climate change resilience. A review

Cacao (Theobroma cacao L.) is a tropical perennial crop which is of great economic importance to the confectionary industry and to the economies of many countries of the humid tropics where it is grown. Some recent studies have suggested climate change could severely impact cacao production in West Africa. It is essential to incorporate our understanding of the physiology and genetic variation within cacao germplasm when discussing the implications of climate change on cacao productivity and developing strategies for climate resilience in cacao production. Here we review the current research on the physiological responses of cacao to various climate factors. Our main findings are 1) water limitation causes significant yield reduction in cacao but genotypic variation in sensitivity is evident, 2) in the field cacao experiences higher temperatures than is often reported in the literature, 3) the complexity of the cacao/ shade tree interaction can lead to contradictory results, 4) elevated CO2 may alleviate some negative effects of climate change 5) implementation of mitigation strategies can help reduce environmental stress, 6) significant gaps in the research need addressing to accelerate the development of climate resilience. Harnessing the significant genetic variation apparent within cacao germplasm is essential to develop modern varieties capable of high yields in non-optimal conditions. Mitigation strategies will also be essential but to use shading to best effect shade tree selection is crucial to avoid resource competition. Cacao is often described as being sensitive to climate change but genetic variation, adaptive responses, appropriate mitigation strategies and interactive climate effects should all be considered when predicting the future of cacao production. Incorporating these physiological responses to various environmental conditions and developing a deeper understanding of the processes underlying these responses will help to accelerate the development of a more resource use efficient tree ensuring sustainable production into the future

Crop Vulnerability to Weather and Climate Risk: Analysis of Interacting Systems and Adaptation Efficacy for Sustainable Crop Production

Climate change is increasing mean and extreme temperatures in the Southwestern United States, leading to a suite of changes affecting agricultural production. These include changes in water, soils, pathogens, weeds, and pests comprising the production environment. The aim of this synthesis is to describe the anticipated leading agricultural pressures and adaptive responses, many of which are near-term actions with longer-term consequences. In the semiarid Southwestern United States, climate change is expected to increase water scarcity. Surface water shortage is the leading reason for recent diminished crop yields in the Southwest. Drought and lack of water represent the leading regional weather-related cause of crop loss from 1989 to 2017. Thus, water scarcity has been and will continue to be a critical factor leading to regional crop vulnerability. Soils, pathogens, weeds, and insects are components of the agricultural production environment and are directly influenced by near-term weather and long-term climate conditions. Field crops, vegetable crops, and perennial crops have unique production requirements and diverse management options, many already used in farm management, to cope with production environment changes to build climate resilience. Farmers and ranchers continuously respond to changing conditions on a near-term basis. Long-term planning and novel adaptation measures implemented may now build nimble and responsive systems and communities able to cope with future conditions. While decision-support tools and resources are providing increasingly sophisticated approaches to cope with production in the 21st century, we strive to keep pace with the cascading barrage of inter-connected agricultural challenges

Table_1_Pregnancy outcomes in a malaria-exposed Malian cohort of women of child-bearing age.pdf

In Sub-Saharan Africa, malaria continues to be associated with adverse pregnancy outcomes including stillbirth, early neonatal death, preterm delivery, and low birth weight. Current preventive measures are insufficient and new interventions are urgently needed. However, before such interventions can be tested in pregnant women, background information on pregnancy outcomes in this target population must be collected. We conducted an observational study in Ouélessébougou, Mali, a malaria-endemic area where first antenatal visit commonly occurs during the second trimester of pregnancy, hindering calculation of miscarriage rate in the population. To accurately determine the rate of miscarriage, 799 non-pregnant women of child-bearing age were enrolled and surveyed via monthly follow up visits that included pregnancy tests. Out of 505 women that completed the study, 364 became pregnant and 358 pregnancies were analyzed: 43 (12%) resulted in miscarriage, 28 (65.1%) occurred during the first trimester of pregnancy. We also determined rates of stillbirth, neonatal death, preterm delivery, and small for gestational age. The results showed high rate of miscarriage during the first trimester and established a basis to evaluate new interventions to prevent pregnancy malaria. This survey design enabled identification of first trimester miscarriages that are often missed by studies conducted in antenatal clinics.Clinical trial registration[https://clinicaltrials.gov/], identifier [NCT0297 4608].</p

‘May God Give Us Chaos, So That We Can Plunder’: A critique of ‘resource curse’ and conflict theories

Kuntala Lahiri-Dutt scrutinizes the increasingly popular theories of the natural resources curse, natural resource conflicts and natural resource wars. She argues that we need to rethink the issues around resource ownership rights as well as the legal frameworks governing and controlling ownership of the mineral-rich tracts of developing countries. Based on her activist research with mining communities she shows that mineral resource management is characterized by multiple actors with their multiple voices, and it is important for us to recognize these actors and listen to their voices. Development (2006) 49, 14–21. doi:10.1057/palgrave.development.1100268