Impact of knowledge management processes on organisational performance: A preliminary study

Copyright @ 2013 EMCIS.Despite the increasing number of studies relating to Knowledge Management (KM) in developed countries, few studies have explored this issue within the context of developing countries. Moreover, some industries have been affected more acutely than others in the transition to a knowledge-based economy. Thus, the purpose of this paper is to evaluate KM processes and to investigate the impact on organisational performance (OP).The authors propose a conceptual model through an in-depth investigation of the previous and current studies in the area of KM and OP. It is envisaged that this model can play a role in guiding the process of KM implementation in order to maximise the beneficial effects of KM processes on OP. An inductive qualitative approach was used based on a preliminary study. A pilot study was conducted; the study involved the use of interview as a primary data collection technique. Content analysis approach was used to identify ideas relevant to the main themes. The study showed that knowledge usage is the most influential aspect of KM that impacts OP. Moreover, the study revealed that knowledge transfer is a common KM process employed by organisations. Accordingly, it was ranked as the second most influential factor of KM with respect to OP

Numerical Construction of LISS Lyapunov Functions under a Small Gain Condition

In the stability analysis of large-scale interconnected systems it is frequently desirable to be able to determine a decay point of the gain operator, i.e., a point whose image under the monotone operator is strictly smaller than the point itself. The set of such decay points plays a crucial role in checking, in a semi-global fashion, the local input-to-state stability of an interconnected system and in the numerical construction of a LISS Lyapunov function. We provide a homotopy algorithm that computes a decay point of a monotone op- erator. For this purpose we use a fixed point algorithm and provide a function whose fixed points correspond to decay points of the monotone operator. The advantage to an earlier algorithm is demonstrated. Furthermore an example is given which shows how to analyze a given perturbed interconnected system.Comment: 30 pages, 7 figures, 4 table

Drop size in a liquid pulsed sieve-plate extraction column

Peer reviewedPublisher PD

The Impact of Proximity to Urban Center on Crop Production Choice and Rural Income: Evidences from Villages in Wollo, Ethiopia

This article attempts to demonstrate how proximity to urban centers influences households' decision to allot their agricultural land to the production of either staple crops or high value cash crops. By applying fractional logit estimation technique on data collected from villages in Wolloof the Amhara Regional State in 2006, it has been found that proximity to urban centers, access to road, and education of the head of the householddetermine the crop choice in favor of the production of high value cash crops. While the purely liquid wealth positively affects the allocation of land for the production of cash crops, the direction of the impact of livestock on crop choice is found to depend on the particular location of the activities in relation to urban (market) centers. The pattern of crop choice has been translated into a variation in the level of per capita income across villages. Households operating in those villages located far from urban centers with no access to road are found to be the poorest among the villages covered by the study.Key Words: Location, Crop Choice, Rural Income, Fractional Logi

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor

Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation. Although the majority of patients initially respond favourably to androgen deprivation therapy, the mean time to relapse is 12-18 months. Currently there are few treatments available for men who have developed resistance to hormone therapy, due to the lack of understanding of the molecular mechanisms underlying development of this disease. Recently, however, major advances have been made in understanding both androgen receptor (AR) dependent and independent pathways which promote development of hormone resistant prostate cancer. This review will focus on modifications to the AR and associated pathways. Molecular modifications to the androgen receptor itself, e.g. mutations and/or amplification, although involved in the development of hormone resistance cannot explain all cases. Phosphorylation of AR, via either Ras/MAP kinase or PI3K/Akt signal transduction pathways, have been shown to activate AR in both a ligand (androgen) dependent and independent fashion. During this review we will discuss the clinical evidence to support AR dependent pathways as mediators of hormone resistance

Proteins across scales through graph partitioning: application to the major peanut allergen Ara h 1

The analysis of community structure in complex networks has been given much attention recently, as it is hoped that the communities at various scales can affect or explain the global behaviour of the system. A plethora of community detection algorithms have been proposed, insightful yet often restricted by certain inherent resolutions. Proteins are multi-scale biomolecular machines with coupled structural organization across scales, which is linked to their function. To reveal this organization, we applied a recently developed multi-resolution method, Markov Stability, which is based on atomistic graph partitioning, along with theoretical mutagenesis that further allows for hot spot identification using Gaussian process regression. The methodology finds partitions of a graph without imposing a particular scale a priori and analyses the network in a computationally efficient way. Here, we show an application on peanut allergenicity, which despite extensive experimental studies that focus on epitopes, groups of atoms associated with allergenic reactions, remains poorly understood. We compare our results against available experiment data, and we further predict distal regulatory sites that may significantly alter protein dynamics

On local structures of cubicity 2 graphs

A 2-stab unit interval graph (2SUIG) is an axes-parallel unit square intersection graph where the unit squares intersect either of the two fixed lines parallel to the $X$-axis, distance $1 + \epsilon$ ($0 < \epsilon < 1$) apart. This family of graphs allow us to study local structures of unit square intersection graphs, that is, graphs with cubicity 2. The complexity of determining whether a tree has cubicity 2 is unknown while the graph recognition problem for unit square intersection graph is known to be NP-hard. We present a polynomial time algorithm for recognizing trees that admit a 2SUIG representation

Structures and waves in a nonlinear heat-conducting medium

The paper is an overview of the main contributions of a Bulgarian team of researchers to the problem of finding the possible structures and waves in the open nonlinear heat conducting medium, described by a reaction-diffusion equation. Being posed and actively worked out by the Russian school of A. A. Samarskii and S.P. Kurdyumov since the seventies of the last century, this problem still contains open and challenging questions.Comment: 23 pages, 13 figures, the final publication will appear in Springer Proceedings in Mathematics and Statistics, Numerical Methods for PDEs: Theory, Algorithms and their Application

Detection of the United States Neisseria meningitidis urethritis clade in the United Kingdom, August and December 2019 - emergence of multiple antibiotic resistance calls for vigilance.

Since 2015 in the United States (US), the US Neisseria meningitidis urethritis clade (US_NmUC) has caused a large multistate outbreak of urethritis among heterosexual males. Its 'parent' strain caused numerous outbreaks of invasive meningococcal disease among men who have sex with men in Europe and North America. We highlight the arrival and dissemination of US_NmUC in the United Kingdom and the emergence of multiple antibiotic resistance. Surveillance systems should be developed that include anogenital meningococci