Large N reduction on coset spaces

As an extension of our previous work concerning the large N reduction on group manifolds, we study the large N reduction on coset spaces. We show that large N field theories on coset spaces are described by certain corresponding matrix models. We also construct Chern-Simons-like theories on group manifolds and coset spaces, and give their reduced models.Comment: 22 pages, typos correcte

T-duality, Fiber Bundles and Matrices

We extend the T-duality for gauge theory to that on curved space described as a nontrivial fiber bundle. We also present a new viewpoint concerning the consistent truncation and the T-duality for gauge theory and discuss the relation between the vacua on the total space and on the base space. As examples, we consider S^3(/Z_k), S^5(/Z_k) and the Heisenberg nilmanifold.Comment: 24 pages, typos correcte

Embedding of theories with SU(2|4) symmetry into the plane wave matrix model

We study theories with SU(2|4) symmetry, which include the plane wave matrix model, 2+1 SYM on RxS^2 and N=4 SYM on RxS^3/Z_k. All these theories possess many vacua. From Lin-Maldacena's method which gives the gravity dual of each vacuum, it is predicted that the theory around each vacuum of 2+1 SYM on RxS^2 and N=4 SYM on RxS^3/Z_k is embedded in the plane wave matrix model. We show this directly on the gauge theory side. We clearly reveal relationships among the spherical harmonics on S^3, the monopole harmonics and the harmonics on fuzzy spheres. We extend the compactification (the T-duality) in matrix models a la Taylor to that on spheres.Comment: 56 pages, 6 figures, v2:a footnote and references added, section 5.2 improved, typos corrected, v3:typos corrected, v4: some equations are corrected, eq.(G.2) is added, conclusion is unchange

Interaction-driven breakdown of dynamical localization in a kicked quantum gas

Quantum interference can terminate energy growth in a continually kicked system, via a single-particle ergodicity-breaking mechanism known as dynamical localization. The effect of many-body interactions on dynamically localized states, while important to a fundamental understanding of quantum decoherence, has remained unexplored despite a quarter-century of experimental studies. We report the experimental realization of a tunably-interacting kicked quantum rotor ensemble using a Bose-Einstein condensate in a pulsed optical lattice. We observe signatures of a prethermal localized plateau, followed for interacting samples by interaction-induced anomalous diffusion with an exponent near one half. Echo-type time reversal experiments establish the role of interactions in destroying reversibility. These results quantitatively elucidate the dynamical transition to many-body quantum chaos, advance our understanding of quantum anomalous diffusion, and delimit some possibilities for protecting quantum information in interacting driven systems.Comment: 17 pages including supp inf

GWAS of bipolar disorder

Genome-wide association studies (GWASs) have identified several susceptibility loci for bipolar disorder (BD) and shown that the genetic architecture of BD can be explained by polygenicity, with numerous variants contributing to BD. In the present GWAS (Phase I/II), which included 2964 BD and 61 887 control subjects from the Japanese population, we detected a novel susceptibility locus at 11q12.2 (rs28456, P=6.4 × 10−9), a region known to contain regulatory genes for plasma lipid levels (FADS1/2/3). A subsequent meta-analysis of Phase I/II and the Psychiatric GWAS Consortium for BD (PGC-BD) identified another novel BD gene, NFIX (P best=5.8 × 10−10), and supported three regions previously implicated in BD susceptibility: MAD1L1 (P best=1.9 × 10−9), TRANK1 (P best=2.1 × 10−9) and ODZ4 (P best=3.3 × 10−9). Polygenicity of BD within Japanese and trans-European-Japanese populations was assessed with risk profile score analysis. We detected higher scores in BD cases both within (Phase I/II) and across populations (Phase I/II and PGC-BD). These were defined by (1) Phase II as discovery and Phase I as target, or vice versa (for ‘within Japanese comparisons’, Pbest~10−29, R2~2%), and (2) European PGC-BD as discovery and Japanese BD (Phase I/II) as target (for ‘trans-European-Japanese comparison,’ Pbest~10−13, R2~0.27%). This ‘trans population’ effect was supported by estimation of the genetic correlation using the effect size based on each population (liability estimates~0.7). These results indicate that (1) two novel and three previously implicated loci are significantly associated with BD and that (2) BD ‘risk’ effect are shared between Japanese and European populations

Localisation and Function of the Endocannabinoid System in the Human Ovary

Although anandamide (AEA) had been measured in human follicular fluid and is suggested to play a role in ovarian follicle and oocyte maturity, its exact source and role in the human ovary remains unclear.Immunohistochemical examination of normal human ovaries indicated that the endocannabinoid system was present and widely expressed in the ovarian medulla and cortex with more intense cannabinoid receptor 2 (CB2) than CB1 immunoreactivity in the granulosa cells of primordial, primary, secondary, tertiary follicles, corpus luteum and corpus albicans. The enzymes, fatty acid amide hydrolase (FAAH) and N-acyclphosphatidylethanolamine-phospholipase D (NAPE-PLD), were only found in growing secondary and tertiary follicles and corpora lutea and albicantes. The follicular fluid (FF) AEA concentrations of 260 FF samples, taken from 37 infertile women undergoing controlled ovarian hyperstimulation for in vitro fertilisation and intracytoplasmic sperm injection with embryo transfer, were correlated with ovarian follicle size (P = 0.03). Significantly higher FF AEA concentrations were also observed in mature follicles (1.43+/-0.04 nM; mean+/-SEM) compared to immature follicles (1.26+/-0.06 nM), P = 0.0142 and from follicles containing morphologically assessed mature oocytes (1.56+/-0.11 nM) compared to that containing immature oocytes (0.99+/-0.09 nM), P = 0.0011. ROC analysis indicated that a FF AEA level of 1.09 nM could discriminate between mature and immature oocytes with 72.2% sensitivity and 77.14% specificity, whilst plasma AEA levels and FF AEA levels on oocyte retrieval day were not significantly different (P = 0.23).These data suggest that AEA is produced in the ovary, is under hormonal control and plays a role in folliculogenesis, preovulatory follicle maturation, oocyte maturity and ovulation

Supramolecularly directed rotary motion in a photoresponsive receptor

Stimuli-controlled motion at the molecular level has fascinated chemists already for several decades. Taking inspiration from the myriad of dynamic and machine-like functions in nature, a number of strategies have been developed to control motion in purely synthetic systems. Unidirectional rotary motion, such as is observed in ATP synthase and other motor proteins, remains highly challenging to achieve. Current artificial molecular motor systems rely on intrinsic asymmetry or a specific sequence of chemical transformations. Here, we present an alternative design in which the rotation is directed by a chiral guest molecule, which is able to bind non-covalently to a light-responsive receptor. It is demonstrated that the rotary direction is governed by the guest chirality and hence, can be selected and changed at will. This feature offers unique control of directional rotation and will prove highly important in the further development of molecular machinery

Health Journalism Internships: A Social Marketing Strategy to Address Health Disparities

The USA seeks to eliminate health disparities by stimulating the rapid uptake of health-promoting behaviors within disadvantaged communities. A health journalism internship incorporates social marketing strategies to increase communities' access to cancer information, while helping the interns who are recruited from underrepresented communities gain admission to top graduate schools. Interns are taught basic health journalism skills that enable them to create immediate streams of cancer-related press releases for submission to community newspapers. Interns are charged with the social responsibility of continuing this dissemination process throughout their careers. Intermediate outcomes are measured as mediators of distal behavioral change goals

BPS solutions in ABJM theory and Maximal Super Yang-Mills on RxS^2

We investigate BPS solutions in ABJM theory on RxS^2. We find new BPS solutions, which have nonzero angular momentum as well as nontrivial configurations of fluxes. Applying the "Higgsing procedure" of arxiv:0803.3218 around a 1/2-BPS solution of ABJM theory, one obtains N=8 super Yang-Mills (SYM) on RxS^2. We also show that other BPS solutions of the SYM can be obtained from BPS solutions of ABJM theory by this higgsing procedure.Comment: 33 pages, v2: minor corrections, references adde

The Asp298 allele of endothelial nitric oxide synthase is a risk factor for myocardial infarction among patients with type 2 diabetes mellitus

Background: Endothelial dysfunction plays a central role in atherosclerotic progression and cardiovascular complications of type 2 diabetes mellitus (T2DM). Given the role of nitric oxide in the vascular system, we aimed to test hypotheses of synergy between the common endothelial nitric oxide synthase (eNOS) Asp(298) allele and T2DM in predisposing to acute myocardial infarction (AMI). Methods: In a population-based patient survey with 403 persons with T2DM and 799 healthy subjects from the population without diabetes or hypertension, we analysed the relation between T2DM, sex and the eNOS Asp(298) allele versus the risk for AMI. Results: In an overall analysis, T2DM was a significant independent risk factor for AMI. In patients with T2DM, homozygosity for the eNOS Asp(298) allele was a significant risk factor (HR 3.12 [1.49-6.56], p = 0.003), but not in subjects without diabetes or hypertension. Compared to wild-type non-diabetic subjects, all patients with T2DM had a significantly increased risk of AMI regardless of genotype. This risk was however markedly higher in patients with T2DM homozygous for the Asp(298) allele (HR 7.20 [3.01-17.20], p < 0.001), independent of sex, BMI, systolic blood pressure, serum triglycerides, HDL -cholesterol, current smoking, and leisure time physical activity. The pattern seemed stronger in women than in men. Conclusion: We show here a strong independent association between eNOS genotype and AMI in patients with T2DM. This suggests a synergistic effect of the eNOS Asp(298) allele and diabetes, and confirms the role of eNOS as an important pathological bottleneck for cardiovascular disease in patients with T2DM