53 research outputs found
Multi-Channel Atomic Scattering and Confinement-Induced Resonances in Waveguides
We develop a grid method for multi-channel scattering of atoms in a waveguide
with harmonic confinement. This approach is employed to extensively analyze the
transverse excitations and deexcitations as well as resonant scattering
processes. Collisions of identical bosonic and fermionic as well as
distinguishable atoms in harmonic traps with a single frequency
permitting the center-of-mass (c.m.) separation are explored in depth. In the
zero-energy limit and single mode regime we reproduce the well-known
confinement-induced resonances (CIRs) for bosonic, fermionic and heteronuclear
collisions. In case of the multi-mode regime up to four open transverse
channels are considered. Previously obtained analytical results are extended
significantly here. Series of Feshbach resonances in the transmission behaviour
are identified and analyzed. The behaviour of the transmission with varying
energy and scattering lengths is discussed in detail. The dual CIR leading to a
complete quantum suppression of atomic scattering is revealed in multi-channel
scattering processes. Possible applications include, e.g., cold and ultracold
atom-atom collisions in atomic waveguides and electron-impurity scattering in
quantum wires.Comment: 35 pages, 18 figure
Genome-wide single nucleotide polymorphism-based autozygosity mapping facilitates identification of mutations in consanguineous families with epidermolysis bullosa
Autozygosity mapping (AM) is a technique utilised for mapping homozygous autosomal recessive (AR) traits and facilitation of genetic diagnosis. We investigated the utility of AM for the molecular diagnosis of heterogeneous AR disorders, using epidermolysis bullosa (EB) as a paradigm. We applied this technique to a cohort of 46 distinct EB families using both short tandem repeat (STR) and genome-wide single nucleotide polymorphism (SNP) array-based AM to guide targeted Sanger sequencing of EB candidate genes. Initially, 39 of the 46 cases were diagnosed with homozygous mutations using this method. Independently, 26 cases, including the seven initially unresolved cases, were analysed with an EB-targeted next-generation sequencing (NGS) panel. NGS identified mutations in five additional cases, initially undiagnosed due to the presence of compound heterozygosity, deep intronic mutations or runs of homozygosity below the set threshold of 2 Mb, for a total yield of 44 of 46 cases (95.7) diagnosed genetically. © 2018 John Wiley & Sons Ltd
A holistic metric approach to solving the dynamic location-allocation problem.
In this paper, we introduce a dynamic variant of the Location-Allocation problem: Dynamic Location-Allocation Problem (DULAP). DULAP involves the location of facilities to service a set of customer demands over a defined horizon. To evaluate a solution to DULAP, we propose two holistic metric approaches: Static and Dynamic Approach. In the static approach, a solution is evaluated with the assumption that customer locations and demand remain constant over a defined horizon. In the dynamic approach, the assumption is made that customer demand, and demographic pattern may change over the defined horizon. We introduce a stochastic model to simulate customer population and distribution over time. We use a Genetic Algorithm and Population-Based Incremental Learning algorithm used in previous work to find robust and satisfactory solutions to DULAP. Results show the dynamic approach of evaluating a solution finds good and robust solutions
A novel mutation in ST14 at a functionally significant amino acid residue expands the spectrum of ichthyosis-hypotrichosis syndrome
Characterization of Isomeric VX Nerve Agent Adducts on Albumin in Human Plasma Using Liquid Chromatography–Tandem Mass Spectrometry
The efficacy of combination of ondansetron and aprepitant on preventing the radiotherapy-induced nausea and vomiting.
Design of Robust Organosuperbases and Anion Receptors by Combination of Azine Heterocycle Skeleton and Phosphazene Motif
Multichannel scattering and loss processes of ultracold atoms in anisotropic harmonic waveguides
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