The effect of lovastatin on cognition impairment induced by bilateral electrical lesion of nucleus basalis magnocellularis in the Alzheimerâs disease model in adult male rats

Background: Statins, inhibitors of 3-hydroxy-3-methyl glutaryl coenzyme A reductase, are widely used as medication to lower cholesterol levels in human patients. Much evidence indicates that statins can also exert neuroprotective actions. So, this study aimed at examining the effect of lovastatin on cognition deficit induced by bilateral electrical lesion of nucleus basalis magnocellularis (NBM) in the Alzheimer’s disease model in adult male rats. Materials and Methods: In this experimental study, 56 adult male wistar rats were divided into 8 groups (n=7): control (intact), NBM lesion group (which received electrically- induced lesion 0.5 mA in 3s), sham group (the electrode was impaled into the NBM with no lesion(, lovastatin groups (lesion+1, 5, 10, 20 mg/kg) and DMSO 5 group (NBM lesion +DMSO 5). Acquisition and retention testing was done by using an eight-radial arm maze in which the patterns of arm entries were recorded for calculating working memory errors, reference memory error and latency in each group. Results: The bilateral NBM lesion resulted in significant reduction of spatial memory in acquisition and retention tests in the form of increased working and reference memory errors compared to the control group (P<0.05). Post-lesion treatment with lovastatin improved the parameters of spatial memory errors in the acquisition and retention tasks compared to the lesion group. Conclusion: The electrical NBM lesion can reduce spatial memory function and the lovastatin therapy after brain injury improved cognitive disorders. It seems that lovastatin by reducing the activity of the acetylcholinesterase enzyme and increasing acetylcholine transferase enzyme activity can cause improvement in learning and memory capability

A laboratory investigation on virulence of Metarhizium anisopliae on Thrips tabaci (Thys.: Thripidae) and its predator, Orius albidipennis (Hem.: Anthocoridae)

In the present study, virulence of three isolates of Metarhizium anisopliae (Ascomycota, Clavicipitaceae) were evaluated on the second instar larvae of the onion thrips, Thrips tabaci Lindman by using spray potter tower at six conidial concentrations of isolates (103-108 conidia/ml) with Thrips Entomopathogenic Bioassay System (TEBS) method. Causing the highest total mortality rate on thrips larvae and having the lowest LC50 value (2.3 Ã 104 conidia/ml), M. anisopliae EUT118 was selected as the highest virulent isolate. Afterwards, the susceptibility of female adults and 5th nymphs of Orius albidipennis (Reuter) was tested against this isolate of M. anisopliae without attendance of host. Results indicated that two stages of predator; female adults and 5th instar nymphs had similarly low susceptibilities to fungal infection. In general, our results revealed that the anthocorid predator, O. albidipennis was less affected by this isolate of fungus. As a result, these two biocontrol agents could be used both together in control programs of T. tabaci in greenhouses

Natural parasitism of Telenomus busseolae (Hym.: Scelionidae) an egg parasitoid of sugarcane stem borers, Sesamia spp. (Lep.: Noctuidae), on sugarcane commercial varieties in Khuzestan

The sugarcane stem borers, Sesamia cretica Led. and S. nonagrioides Lef. are the most important pests of sugarcane in Iran. The egg parasitoid wasp, Telenomus busseolae Gahan is the most important natural enemy of Sesamia spp. in Khuzestan province that play an important role in regulating populations of sugarcane stem borers. A field experiment was conducted to evaluate the performance of T. busseolae on sugarcane commercial varieties in Khuzestan province (southwest of Iran). This study was conducted in a split plot design on 4 sugarcane commercial varieties (i.e. CP69-1062, CP48-103, CP57-614 and SP70-1143) with 5 fields per variety in Khuzestan in 2007. The sampling of egg masses were carried out within the tillering stage of sugarcane (5-15 June) and the final stage of sugarcane growing (10-20 October). Our results indicated that both growth stage and variety of sugarcane had a significant effect on the egg batch density, discovery efficiency and percent parasitism. The interaction between growth stage and variety on percent parasitism and discovery efficiency were statistically different (

Comparison of the virulence of some Iranian isolates of Beauveria bassiana to Eurygaster integriceps (Hem.: Scutelleridae) and production of the selected isolate

The virulence of four Iranian isolates and one exotic isolate of Beauveria bassiana on the fifth instar nymphs and also five Iranian isolates and one exotic isolate of it on the adults of Eurygaster integriceps Puton was studied using dipping and topical micro-application techniques, respectively. Nymphs were highly susceptible to the isolates. Comparison of LC50 values showed no significant difference among the isolates to nymphs. In case of the adults, LD50 values of DEBI 002, DEBI 006 and DEBI 008 were comparatively lower than those of other isolates (0.05% Tween 80® solution treatment). Coincidentally, DEBI 002 showed the lowest LD50 value among the others (odorless kerosene treatment). In addition, DEBI 002 showed the lowest LT50 value to adults. In production phase, the effects of different liquid culture media (microbiological glucose, biochemical glucose, chemistry sucrose and sugar) supplemented with yeast extract and solid media (rice, wheat and barley) were studied on blastospore and conidial production, respectively. The highest total yield was obtained 0.801 à 107 blastospores/ml media after 4 days for microbiological glucose plus yeast extract. Maximum conidial production was achieved 1.17 à 109 conidia/gr substrate using rice as medium. Viability of produced conidia on different solid media showed no significant difference among treatments

Life history parameters of Thrips tabaci (Thys.: Thripidae) on cucumber, sweet pepper and eggplant under laboratory conditions

Onion thrips, Thrips tabaci Lindeman, is one of the most important pests of vegetables and ornamentals all over the world. Its role has been proved in the transmission of different viruses to several plants. In this study, life history parameters of T. tabaci were calculated on three host plants, cucumber, sweet pepper and eggplant. Experiments were conducted at 25 ± 1οC, 60 ± 10% R.H. and photoperiod of 16: 8 (L: D) hours. The results showed that host plants affect life history of onion thrips significantly. Intrinsic rate of population increase (rm) was 0.296, 0.158 and 0.234 female on female per day on cucumber, sweet pepper and eggplant respectively. Other parameters like λ (finite rate of increase) were 1.334, 1.171 and 1.264; T (mean generation time) were 14.879, 19.092 and 16.779; DT (doubling time) were 2.343, 4.384 and 2.956 days. Finally, R0 (net reproductive rate) was 81.581, 20.461 and 51.141 female/female in one generation. With regard to highly significant effect of host plants on life history parameters of onion thrips, it is probable that this problem could be used for control of onion thrips on sweet pepper more effectively than on cucumber and eggplant

Study on potential of some solid natural substances in production of Beauveria bassiana (Ascomycota, Cordycipitaceae) conidia

In this study, two fungus isolates, Beauveria bassiana EUT105 and B. bassiana EUT116, were evaluated for production of aerial conidia on wheat, wheat flour, wheat bran, rice flour, rice bran, rice paddy, millet and corn flour using two phasic liquid-solid system. Data analysis showed that there are significant differences among treatments (simple media) in both isolates. In B. bassiana EUT105, the maximum and minimum productions were achieved on wheat bran, 2.3 Ã 1010 conidia/g and on rice paddy, 1.5 Ã 109 conidia/g of medium, respectively. In B. bassiana EUT116, wheat bran with 6.1 Ã 109 conidia/g and millet with 8 Ã 108 conidia/g had the maximum and minimum productions, respectively. Effect of adding nutritional complementary compounds to the growth media was significant in increasing of conidial yield. Related results showed that adding permeate increased the production but molasses did not it in comparison with control in both isolates. Wheat bran plus permeate had the maximum production, 5 Ã 1010 and 4.6 Ã 1010 conidia/g in B. bassiana EUT105 and EUT116, respectively and minimum production was obtained with rice flour plus molasses, 1.5 Ã 108 and 6 Ã 108 conidia/g in B. bassiana EUT105 and EUT116, respectively

Investigation of presence, distribution and flight period of oak leaf roller moth, Tortrix viridana (Lep.: Tortricidae) using pheromone traps in Kurdistan province

Forests cover about 5,200,000 hectares of the west of Iran, from which 500,000 hectares are located in Kurdistan province. One of the most important pests in the oak forests of this province is oak leaf roller moth, Tortrix viridana L. (Lep.: Tortricidae). This pest significantly damages the oak forest each year. Using pheromone trap is one of the suitable methods for monitoring of this pest. In this work, distribution and flight period of the pest were studied by pheromone traps during two years. Fifteen regions were trapped at the equal distances (40 km) from Kamyaran (south west of Kurdistan province) to Baneh (north west of Kurdistan province) to investigate the presence and distribution of this moth. Also, a region located between Sanandaj and Marivan was selected to study the flight period. Some traps were established in this region and checked every two days. Investigation of pest distribution showed that oak leaf roller moth was present all over the sites from Kamyaran to Baneh. Different populations of moth were trapped in all over the sites. The highest population was trapped in Colit region (mid-west of Kurdistan province). The study of flight period showed that first moths were trapped on May, 16th and the peak of the flight took place on May, 21st and finally the last moths were trapped on June, 24th. Therefore, adults activated during 40 days; mating and oviposition occurred during this period. Incubation period lasted 9 months and activation of larvae was coincident with flashing of foliar buds

Report of a thelytokous population of Lysiphlebus fabarum (Hym.: Aphidiidae) from Iran

به منظور جمع‌آوری و شناسایی پارازیتوئیدهای شته‌ی سیاه باقلا، Scopoli Aphis fabae، از مزارع باقلای منطقه‌ی چورزق زنجان در اواسط خرداد‌ماه 1386 نمونه‌برداری به عمل آمد. در بین نمونه‌ها، جمعیت ماده‌‌زای زنبور پارازیتوئید Lysiphlebus fabarum (Marshall) از خانواده‌ی Aphidiidae شناسایی شد که برای اولین‌بار از ایران گزارش می‌‌شود. در زیر برخی ازویژگی‌‌های مهم تولید مثلی و چگونگی پراکنش جغرافیایی این جمعیت ارایه شده است

Microfluidic systems for the analysis of the viscoelastic fluid flow phenomena in porous media

In this study, two microfluidic devices are proposed as simplified 1-D microfluidic analogues of a porous medium. The objectives are twofold: firstly to assess the usefulness of the microchannels to mimic the porous medium in a controlled and simplified manner, and secondly to obtain a better insight about the flow characteristics of viscoelastic fluids flowing through a packed bed. For these purposes, flow visualizations and pressure drop measurements are conducted with Newtonian and viscoelastic fluids. The 1-D microfluidic analogues of porous medium consisted of microchannels with a sequence of contractions/ expansions disposed in symmetric and asymmetric arrangements. The real porous medium is in reality, a complex combination of the two arrangements of particles simulated with the microchannels, which can be considered as limiting ideal configurations. The results show that both configurations are able to mimic well the pressure drop variation with flow rate for Newtonian fluids. However, due to the intrinsic differences in the deformation rate profiles associated with each microgeometry, the symmetric configuration is more suitable for studying the flow of viscoelastic fluids at low De values, while the asymmetric configuration provides better results at high De values. In this way, both microgeometries seem to be complementary and could be interesting tools to obtain a better insight about the flow of viscoelastic fluids through a porous medium. Such model systems could be very interesting to use in polymer-flood processes for enhanced oil recovery, for instance, as a tool for selecting the most suitable viscoelastic fluid to be used in a specific formation. The selection of the fluid properties of a detergent for cleaning oil contaminated soil, sand, and in general, any porous material, is another possible application

Laser-Beam-Patterned Topological Insulating States on Thin Semiconducting MoS2

Identifying the two-dimensional (2D) topological insulating (TI) state in new materials and its control are crucial aspects towards the development of voltage-controlled spintronic devices with low-power dissipation. Members of the 2D transition metal dichalcogenides have been recently predicted and experimentally reported as a new class of 2D TI materials, but in most cases edge conduction seems fragile and limited to the monolayer phase fabricated on specified substrates. Here, we realize the controlled patterning of the 1T′ phase embedded into the 2H phase of thin semiconducting molybdenum-disulfide by laser beam irradiation. Integer fractions of the quantum of resistance, the dependence on laser-irradiation conditions, magnetic field, and temperature, as well as the bulk gap observation by scanning tunneling spectroscopy and theoretical calculations indicate the presence of the quantum spin Hall phase in our patterned 1T′ phasesThe work carried out at Aoyama Gakuin University was partly supported by a grant for private universities and a Grant-in-Aid for Scientific Research (JP15K13277) awarded by MEXT. The work at the University of Tokyo was partly supported by Grantin-Aid for Scientific Research (JP17K05492, JP18H04218 and JP19H00652). J. J. P. and S. P. acknowledge Spanish MINECO through Grant No. FIS2016-80434-P, the Fundación Ramón Areces, the María de Maeztu Program for Units of Excellence in R&D (MDM-2014- 0377), the Comunidad Autónoma de Madrid through NANOMAGCOST Program, and the European Union Seventh Framework Programme under Grant Agreement No. 604391 Graphene Flagship. S. P. acknowledges the computer resources and assistance provided by the Centro de Computación Científica of the Universidad Autónoma de Madrid. S. P. was also supported by the VILLUM FONDEN via the Center of Excellence for Dirac Materials (Grant No. 11744). D. M. and E. G.-M. gratefully acknowledge support from the Graphene Flagship Graphene Core2 Contract No. 785219. E. G.-M also acknowledges IJCI-2017-32297 from Spanish MINECO/AE