20 research outputs found
A pore scale analysis for determination of interfacial convective heat transfer coefficient for thin periodic porous media under mixed convection
Increased oxidative stress in patients with familial Mediterranean fever during attack period
Objectives: We aimed to investigate the status of oxidant and
antioxidants during attack period (AP) and attack free periods (AFP) in
Familial Mediterranean fever (FMF) patients. Methods: Measured the
levels of malondialdehyde (MDA), protein carbonyl (PC), glutathione
(GSH) and antioxidant vitamins (A,C and E) as well as the activities of
catalase (CAT) and glutathione peroxidase (GSH-Px) in serum and whole
blood of FMF patients in FMF-AP and FMF-AFP. Results: Levels of MDA
and PC were found significantly higher (p <0.05) both in serum and
whole blood of FMF-AP group compared with other groups. The CAT and
GSH-Px activities in FMF-AP group were found markedly lower (p
<0.05) comparing to HC group. However, there were no statistically
significant differences between the groups in terms of antioxidant
vitamin levels. Conclusions: Our study demonstrated increased
oxidative stress in patients with FMF during AP. Investigations are
needed to establish the effect of antioxidant supplementation on FMF
attack frequency and severity. We also suggest that these increased MDA
and PC levels and decreased antioxidants may be used as supportive
markers to differentiate AP from AFP. These conclusions need to be
validated in further multicenter studies with high number of FMF
patients