Mef2 induction of the immediate early gene Hr38/Nr4a is terminated by Sirt1 to promote ethanol tolerance.

Drug naïve animals given a single dose of ethanol show changed responses to subsequent doses, including the development of ethanol tolerance and ethanol preference. These simple forms of behavioral plasticity are due in part to changes in gene expression and neuronal properties. Surprisingly little is known about how ethanol initiates changes in gene expression or what the changes do. Here we demonstrate a role in ethanol plasticity for Hr38, the sole Drosophila homolog of the mammalian Nr4a1/2/3 class of immediate early response transcription factors. Acute ethanol exposure induces transient expression of Hr38 and other immediate early neuronal activity genes. Ethanol activates the Mef2 transcriptional activator to induce Hr38, and the Sirt1 histone/protein deacetylase is required to terminate Hr38 induction. Loss of Hr38 decreases ethanol tolerance and causes precocious but short-lasting ethanol preference. Similarly, reduced Mef2 activity in all neurons or specifically in the mushroom body α/β neurons decreases ethanol tolerance; Sirt1 promotes ethanol tolerance in these same neurons. Genetically decreasing Hr38 expression levels in Sirt1 null mutants restores ethanol tolerance, demonstrating that both induction and termination of Hr38 expression are important for behavioral plasticity to proceed. These data demonstrate that Hr38 functions as an immediate early transcription factor that promotes ethanol behavioral plasticity

Investigation to optimize the passive shock wave-boundary layer control for supercritical airfoil drag reduction

The optimization of passive shock wave/boundary layer control for supercritical airfoil drag reduction was investigated in a 3 in. x 15.4 in. Transonic Blowdown Wind Tunnel. A 14% thick supercritical airfoil was tested with 0%, 1.42% and 2.8% porosities at Mach numbers of .70 to .83. The 1.42% case incorporated a linear increase in porosity with the flow direction while the 2.8% case was uniform porosity. The static pressure distributions over the airfoil, the wake impact pressure data for determining the profile drag, and the Schlieren photographs for porous surface airfoils are presented and compared with the results for solid-surface airfoils. While the results show that linear 1.42% porosity actually led to a slight increase in drag it was found that the uniform 2.8% porosity can lead to a drag reduction of 46% at M = .81

Anodized aluminium pressure sensitive paint: effect of paint application technique

The porous surface of the Anodized Aluminium Pressure Sensitive Paint (AA-PSP) is what differentiates it from conventional sol–gel based PSPs, leading to a faster response time of the paint. The objective of the current study is to examine the effect of the paint application technique, i.e., whether the AA substrate is dipped or sprayed, on the pressure and temperature sensitivity. A more practical procedure for preparing the AA samples is also presented. Scanning Electron Microscope (SEM) images are acquired together with the calibration of the AA-PSP at various temperatures and pressures to determine the effectiveness of each application technique. The results revealed that the AA sample which was dipped in the PSP solution shows a higher pressure sensitivity than the sprayed one. The SEMs show that spraying leads to the covering up of the micropores created on the surface and undermining the benefit of anodization

Comparing alignment factors in SMEs and large organizations: a planning integration perspective

Measurement of the alignment between business strategies and information systems (IS) has demonstrated positive impact for the organizational performance. The factors that have proved relevant when assessing the maturity level of alignment are: communication, competency/value measurement, governance, partnership, architecture & scope, and skills. Existing research, however, has focused on the assessment of these factors on large organizations and has barely explored their impact on Small and Medium Enterprises (SME). This paper uses the data provided by 127 participants from large and SMEs in order to identify whether the aforementioned factors are also relevant for assessing the level of alignment maturity in SMEs. The results from this research suggest that there are not significant differences between large organizations and SMEs when assessing those factors. In addition, this research also explored the relation between different planning integration of alignment (independent, sequential and simultaneous) in order to measure the perceived relevance of the factors. The results suggest that the planning integration identified on SMEs and large organizations has a positive correlation on how these factors are ranked. For both SMEs and large organizations where the formulation is simultaneous, the relevance of the factors is higher perceived than it is for those where the formulation is independent or sequential

Compressible vortex loops: effect of nozzle geometry

Vortex loops are fundamental building blocks of supersonic free jets. Isolating them allows for an easier study and better understanding of such flows. The present study looks at the behaviour of compressible vortex loops of different shapes, generated due to the diffraction of a shock wave from a shock tube with different exit nozzle geometries. These include a 15 mm diameter circular nozzle, two elliptical nozzles with minor to major axis ratios of 0.4 and 0.6, a 30 × 30 mm square nozzle, and finally two exotic nozzles resembling a pair of lips with minor to major axis ratios of 0.2 and 0.5. The experiments were performed for diaphragm pressure ratios of P4/P1=4, 8, and 12, with P4 and P1 being the pressures within the high pressure and low pressure compartments of the shock tube, respectively. High-speed schlieren photography as well as PIV measurements of both stream-wise and head-on flows have been conducted

Detonation driven shock wave interactions with perforated plates

The study of detonations and their interactions is vital for the understanding of the high-speed flow physics involved and the ultimate goal of controlling their detrimental effects. However, producing safe and repeatable detonations within the laboratory can be quite challenging, leading to the use of computational studies which ultimately require experimental data for their validation. The objective of this study is to examine the induced flow field from the interaction of a shock front and accompanying products of combustion, produced from the detonation taking place within a non-electrical tube lined with explosive material, with porous plates with varying porosities, 0.7–9.7%. State of the art high-speed schlieren photography alongside high-resolution pressure measurements is used to visualise the induced flow field and examine the attenuation effects which occur at different porosities. The detonation tube is placed at different distances from the plates' surface, 0–30 mm, and the pressure at the rear of the plate is recorded and compared. The results indicate that depending on the level of porosity and the Mach number of the precursor shock front secondary reflected and transmitted shock waves are formed through the coalescence of compression waves. With reduced porosity, the plates act almost as a solid surface, therefore the shock propagates faster along its surface

Application of pressure-sensitive paints to unsteady and high-speed flows

The Pressure-Sensitive Paint (PSP) technique allows the global pressure mapping of surfaces under aerodynamic conditions. The present study involves the application of Tris- Bathophenanthroline Ruthenium Perchlorate based PSP, developed in-house, to two different cases; a) the flow through a sonic nozzle, and b) the examination of the effect of dimples on glancing shock wave turbulent boundary layer interactions at transonic speeds

Relativistic Planck-scale polymer

Polymer quantum mechanics has been studied as a simplified picture that reflects some of the key properties of Loop Quantum Gravity; however, while the fate of relativistic symmetries in Loop Quantum Gravity is still not established, it is usually assumed that the discrete polymer structure should lead to a breakdown of relativistic symmetries. We here focus for simplicity on a one-spatial-dimension polymer model and show that relativistic symmetries are deformed, rather than being broken. The specific type of deformed relativistic symmetries which we uncover appears to be closely related to analogous descriptions of relativistic symmetries in some noncommutative spacetimes. This also contributes to an ongoing effort attempting to establish whether the "quantum-Minkowski limit" of Loop Quantum Gravity is a noncommutative spacetime.Comment: 5 pages, no figures. v2: minor changes in Section I

Entangled and disentangled evolution for a single atom in a driven cavity

For an atom in an externally driven cavity, we show that special initial states lead to near-disentangled atom-field evolution, and superpositions of these can lead to near maximally-entangled states. Somewhat counterintutively, we find that (moderate) spontaneous emission in this system actually leads to a transient increase in entanglement beyond the steady-state value. We also show that a particular field correlation function could be used, in an experimental setting, to track the time evolution of this entanglement