Strings on Bubbling Geometries

We study gauge theory operators which take the form of a product of a trace with a Schur polynomial, and their string theory duals. These states represent strings excited on bubbling AdS geometries which are dual to the Schur polynomials. These geometries generically take the form of multiple annuli in the phase space plane. We study the coherent state wavefunction of the lattice, which labels the trace part of the operator, for a general Young tableau and their dual description on the droplet plane with a general concentric ring pattern. In addition we identify a density matrix over the coherent states on all the geometries within a fixed constraint. This density matrix may be used to calculate the entropy of a given ensemble of operators. We finally recover the BMN string spectrum along the geodesic near any circle from the ansatz of the coherent state wavefunction.Comment: 41 pages, 12 figures, published version in JHE

Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability.

In cells lacking telomerase, telomeres gradually shorten during each cell division to reach a critically short length, permanently activate the DNA damage checkpoint, and trigger replicative senescence. The increase in genome instability that occurs as a consequence may contribute to the early steps of tumorigenesis. However, because of the low frequency of mutations and the heterogeneity of telomere-induced senescence, the timing and mechanisms of genome instability increase remain elusive. Here, to capture early mutation events during replicative senescence, we used a combined microfluidic-based approach and live-cell imaging in yeast. We analyzed DNA damage checkpoint activation in consecutive cell divisions of individual cell lineages in telomerase-negative yeast cells and observed that prolonged checkpoint arrests occurred frequently in telomerase-negative lineages. Cells relied on the adaptation to the DNA damage pathway to bypass the prolonged checkpoint arrests, allowing further cell divisions despite the presence of unrepaired DNA damage. We demonstrate that the adaptation pathway is a major contributor to the genome instability induced during replicative senescence. Therefore, adaptation plays a critical role in shaping the dynamics of genome instability during replicative senescence

The Alvin Sun

Semiweekly newspaper from Alvin, Texas that includes local, state, and national news along with advertising

The Alvin Sun

Semiweekly newspaper from Alvin, Texas that includes local, state, and national news along with advertising

The Alvin Sun

Semiweekly newspaper from Alvin, Texas that includes local, state, and national news along with advertising

The Alvin Sun

Semiweekly newspaper from Alvin, Texas that includes local, state, and national news along with advertising

The Alvin Sun

Semiweekly newspaper from Alvin, Texas that includes local, state, and national news along with advertising

The Alvin Sun

Semiweekly newspaper from Alvin, Texas that includes local, state, and national news along with advertising

The Alvin Sun

Semiweekly newspaper from Alvin, Texas that includes local, state, and national news along with advertising

The Alvin Sun

Semiweekly newspaper from Alvin, Texas that includes local, state, and national news along with advertising