448 research outputs found
Histology of tbe fissure contents in completely impacted teeth
Nous avons Ă©tudiĂ© les fissures occlusales et leur contenu au niveau de dents complĂštement incluses Ă lâaide du microscope optique et Ă©lectronique et obtenu quelques rĂ©sultats intĂ©ressants. Câest-Ă -dire au microscope optique, lâexamen des coupes de fissures ont montrĂ©:a) Un certain nombre de fissures Ă©taient comblĂ©es.b) Dâautres Ă©taient comblĂ©es Ă certains endroits limitĂ©s, localisĂ©s le long des murs de la fissure.c) Dâautres enfin ne contenaient rien et les fissures Ă©taient pratiquement vides.La fine structure du contenu des fissures ne pouvait pas ĂȘtre prĂ©cisĂ©e au microscope optique et lâinterprĂ©tation ne peut quâĂȘtre subjective.ObservĂ©s au microscope Ă©lectronique, les dĂ©pĂŽts comblant les fissures se sont avĂ©rĂ©s ĂȘtre de lâĂ©mail hypominĂ©ralisĂ©
Index Theorem and Overlap Formalism with Naive and Minimally Doubled Fermions
We present a theoretical foundation for the Index theorem in naive and
minimally doubled lattice fermions by studying the spectral flow of a Hermitean
version of Dirac operators. We utilize the point splitting method to implement
flavored mass terms, which play an important role in constructing proper
Hermitean operators. We show the spectral flow correctly detects the index of
the would-be zero modes which is determined by gauge field topology. Using the
flavored mass terms, we present new types of overlap fermions from the naive
fermion kernels, with a number of flavors that depends on the choice of the
mass terms. We succeed to obtain a single-flavor naive overlap fermion which
maintains hypercubic symmetry.Comment: 27 pages, 17 figures; references added, version accepted in JHE
Ecto-5â-nucleotidase: Structure function relationships
Ecto-5â-nucleotidase (ecto-5â-NT) is attached via a GPI anchor to the extracellular membrane, where it hydrolyses AMP to adenosine and phosphate. Related 5â-nucleotidases exist in bacteria, where they are exported into the periplasmic space. X-ray structures of the 5â-nucleotidase from E. coli showed that the enzyme consists of two domains. The N-terminal domain coordinates two catalytic divalent metal ions, whereas the C-terminal domain provides the substrate specificity pocket for the nucleotides. Thus, the substrate binds at the interface of the two domains. Here, the currently available structural information on ecto-5âNT is reviewed in relation to the catalytic properties and enzyme function
Properties of Graphene: A Theoretical Perspective
In this review, we provide an in-depth description of the physics of
monolayer and bilayer graphene from a theorist's perspective. We discuss the
physical properties of graphene in an external magnetic field, reflecting the
chiral nature of the quasiparticles near the Dirac point with a Landau level at
zero energy. We address the unique integer quantum Hall effects, the role of
electron correlations, and the recent observation of the fractional quantum
Hall effect in the monolayer graphene. The quantum Hall effect in bilayer
graphene is fundamentally different from that of a monolayer, reflecting the
unique band structure of this system. The theory of transport in the absence of
an external magnetic field is discussed in detail, along with the role of
disorder studied in various theoretical models. We highlight the differences
and similarities between monolayer and bilayer graphene, and focus on
thermodynamic properties such as the compressibility, the plasmon spectra, the
weak localization correction, quantum Hall effect, and optical properties.
Confinement of electrons in graphene is nontrivial due to Klein tunneling. We
review various theoretical and experimental studies of quantum confined
structures made from graphene. The band structure of graphene nanoribbons and
the role of the sublattice symmetry, edge geometry and the size of the
nanoribbon on the electronic and magnetic properties are very active areas of
research, and a detailed review of these topics is presented. Also, the effects
of substrate interactions, adsorbed atoms, lattice defects and doping on the
band structure of finite-sized graphene systems are discussed. We also include
a brief description of graphane -- gapped material obtained from graphene by
attaching hydrogen atoms to each carbon atom in the lattice.Comment: 189 pages. submitted in Advances in Physic
Mechanisms of organelle division and inheritance and their implications regarding the origin of eukaryotic cells
Mitochondria and plastids have their own DNAs and are regarded as descendants of endosymbiotic prokaryotes. Organellar DNAs are not naked in vivo but are associated with basic proteins to form DNA-protein complexes (called organelle nuclei). The concept of organelle nuclei provides a new approach to explain the origin, division, and inheritance of organelles. Organelles divide using organelle division rings (machineries) after organelle-nuclear division. Organelle division machineries are a chimera of the FtsZ (filamentous temperature sensitive Z) ring of bacterial origin and the eukaryotic mechanochemical dynamin ring. Thus, organelle division machineries contain a key to solve the origin of organelles (eukaryotes). The maternal inheritance of organelles developed during sexual reproduction and it is also probably intimately related to the origin of organelles. The aims of this review are to describe the strategies used to reveal the dynamics of organelle division machineries, and the significance of the division machineries and maternal inheritance in the origin and evolution of eukaryotes
Collagen mRNA levels changes during colorectal cancer carcinogenesis
<p>Abstract</p> <p>Background</p> <p>Invasive growth of epithelial cancers is a complex multi-step process which involves dissolution of the basement membrane. Type IV collagen is a major component in most basement membranes. Type VII collagen is related to anchoring fibrils and is found primarily in the basement membrane zone of stratified epithelia. Immunohistochemical studies have previously reported changes in steady-state levels of different α(IV) chains in several epithelial cancer types. In the present study we aimed to quantitatively determine the mRNA levels of <it>type IV collagen (α1/α4/α6) </it>and <it>type VII collagen (α1) </it>during colorectal cancer carcinogenesis.</p> <p>Methods</p> <p>Using quantitative RT-PCR, we have determined the mRNA levels for <it>α1(IV), α4(IV), α6(IV), and α1(VII) </it>in colorectal cancer tissue (n = 33), adenomas (n = 29) and in normal tissue from the same individuals. In addition, corresponding tissue was examined from healthy volunteers (n = 20). mRNA levels were normalized to <it>ÎČ-actin</it>. Immunohistochemical analysis of the distributions of type IV and type VII collagens were performed on normal and affected tissues from colorectal cancer patients.</p> <p>Results</p> <p>The <it>α1(IV) </it>and <it>α1(VII) </it>mRNA levels were statistically significantly higher in colorectal cancer tissue (p < 0.001) as compared to corresponding tissue from healthy controls. This is an early event as tissue from adenomas also displayed a higher level. There were small changes in the levels of <it>α4(IV)</it>. The level of <it>α6(IV) </it>was 5-fold lower in colorectal cancer tissue as compared to healthy individuals (p < 0.01). The localisation of type IV and type VII collagen was visualized by immunohistochemical staining.</p> <p>Conclusion</p> <p>Our results suggest that the down-regulation of <it>α6(IV</it>) mRNA coincides with the acquisition of invasive growth properties, whereas <it>α1(IV) </it>and <it>α1(VII) </it>mRNAs were up-regulated already in dysplastic tissue. There are no differences in collagen expression between tissues from healthy individuals and normal tissues from affected individuals.</p
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