Feedforward and feedback control in apraxia of speech: effects of noise masking on vowel production

PURPOSE: This study was designed to test two hypotheses about apraxia of speech (AOS) derived from the Directions Into Velocities of Articulators (DIVA) model (Guenther et al., 2006): the feedforward system deficit hypothesis and the feedback system deficit hypothesis. METHOD: The authors used noise masking to minimize auditory feedback during speech. Six speakers with AOS and aphasia, 4 with aphasia without AOS, and 2 groups of speakers without impairment (younger and older adults) participated. Acoustic measures of vowel contrast, variability, and duration were analyzed. RESULTS: Younger, but not older, speakers without impairment showed significantly reduced vowel contrast with noise masking. Relative to older controls, the AOS group showed longer vowel durations overall (regardless of masking condition) and a greater reduction in vowel contrast under masking conditions. There were no significant differences in variability. Three of the 6 speakers with AOS demonstrated the group pattern. Speakers with aphasia without AOS did not differ from controls in contrast, duration, or variability. CONCLUSION: The greater reduction in vowel contrast with masking noise for the AOS group is consistent with the feedforward system deficit hypothesis but not with the feedback system deficit hypothesis; however, effects were small and not present in all individual speakers with AOS. Theoretical implications and alternative interpretations of these findings are discussed.R01 DC002852 - NIDCD NIH HHS; R01 DC007683 - NIDCD NIH HH

Professionnalisme, internationalisme, universalisme

En se basant sur une recherche anthropologique réalisée auprès de médecins finnois du Comité International de la Croix-Rouge (CICR) qui ont travaillé dans des zones de guerre et de conflits à travers le monde, cet article examine les politiques et l’éthique de la neutralité, de l’internationalisme et du professionnalisme. Celles-ci seront considérées en relation avec les débats actuels portant sur l’universalisme.Based on anthropological research with Finnish medical professionals of the International Committee of the Red Cross (ICRC) who have worked in war and conflict zones around the world, this essay examines the politics and ethics of neutrality, internationalism and professionalism. These are considered in relation to current debates about universalisms.Basado en una investigación antropológica realizada entre los médicos finlandeses del Comité Internacional de la Cruz-Roja (CICR), que han trabajado en las zonas de guerra y de conflicto a través del mundo, este artículo examina las políticas y la ética de la neutralidad, del internacionalismo y del profesionalismo. Los abordamos en relación a los debates actuales sobre el universalismo

Newly graduated nurses' empowerment regarding professional competence and other work-related factors

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Neuropsychological outcome of cognitive training in mild to moderate dementia : A randomized controlled trial

Effectiveness of a 12-week cognitive training (CT) programme for community-dwelling patients with dementia was evaluated on various cognitive functions (attention, memory, executive functions and reasoning) and psychological well-being (PWB). A single-blind randomized controlled trial was conducted in adult day care centres in Helsinki, Finland. Participants (N = 147) were older individuals with mild to moderate dementia living at home and attending day care (mean age 83 years, 72% female, 63% at mild stage of dementia). The intervention group (n= 76) received systematic CT for 45 min twice a week while the control group (n = 71) attended day care as usual. The cognitive and psychological outcomes were measured at baseline, and followed up at 3 and 9 months. No differences between the two groups in changes of any of the cognitive functions, or PWB over time were found. We observed a positive trend at 3 months in the change for PWB favouring the intervention group, but no significant interaction effect was found (p = .079;d = -0.31). Thus, systematic CT appears to have no effect on neuropsychological outcomes of cognitive functioning and PWB in older adults who already have dementia.Peer reviewe

The Discursive Divide: Women in the IT Industry

The complex problem of declining female participation in the IT industry has been conceptualised in a number of vivid images – the shrinking pipeline, the pink collar work force and the digital divide. This paper argues that women working in IT are discursively divided from the ‘masculine’ domain of IT and from other women by distinctive discursive practices. This paper discusses the use of discourse analysis to examine the interview data from a recent study of professional women in the IT industry, focusing on the way that such discourse constitutes the industry and supports gendered divisions in work and education. The paper explains the text-oriented approach to discourse analysis and how interpretation of the interview discourse is carried out, particularly in relation to the notion of denotation. Specifically, the discourse reveals dualisms in the women’s discourse on IT work, which act as interpretive schemes but which also create a divide between ‘female’ and ‘male’ attitudes, attributes and skills. It is acknowledged that everyday talk routinely comprises contradictory themes, reflecting participants’ need to make sense of routine activities and to resolve dilemmas in their sense of identity. However, this paper argues that the identification of such contradictions can contribute to our understanding of the digital divide, which exists between men and women in the IT industry

A novel partial de novo duplication of JARID2 gene causing a neurodevelopmental phenotype

Publisher Copyright: © 2022 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC.Background: Deletions covering the entire or partial JARID2 gene as well as pathogenic single nucleotide variants leading to haploinsufficiency of JARID2 have recently been shown to cause a clinically distinct neurodevelopmental syndrome. Here, we present a previously undescribed partial de novo duplication of the JARID2 gene in a patient displaying features similar to those of patients with JARID2 loss-of-function variants. Case report: The index patient presents with abnormalities in gross motor skills and speech development as well as neuropsychiatric disorders. The patient has markedly dark infraorbital circles and slightly prominent supraorbital ridges.Whole-genome sequencing and array comparative genomic hybridization revealed a novel disease-causing variant type, a partial tandem duplication of JARID2, covering the exons 1–7. Furthermore, RNA sequencing validated the increased expression of these exons. Expression alterations were also detected in target genes of the PRC2 complex, in which JARID2 acts as an essential member. Conclusion: Our data add to the variety of different pathogenic variants associated with JARID2 neurodevelopmental syndrome.Peer reviewe

Interaction between clients and physiotherapists in group exercise classes in geriatric rehabilitation

The aim of this paper is to explore how older people construct their interaction in group exercise classes in geriatric rehabilitation and what is their contribution to the interaction. Discourse analysis was employed and data, consisting of seven videotaped group-based exercise sessions, were collected from 52 older people (aged 66–93 years) and nine rehabilitation professionals in seven rehabilitation centres. Four discourse categories were found. In “taciturn exercising”, older people remained verbally silent but physically active. In “submissive disagreeing”, older people opposed the professionals’ agenda by displaying reluctant consent to proposals. In “resilient endeavouring”, older adults persisted on their course of action, regardless of the disapproval of the professionals. In “lay helping”, older people initiated spontaneous encouragement, but also gave verbal and physical assistance to their peers. Older people's meaningful contribution to interaction, whilst it may challenge the institutional flow of activities, can constitute an integral part of the re-ablement process of rehabilitation

Monetary value of informal caregiving in dementia from a societal perspective

Peer reviewe

Urban and rural dietary patterns are associated with anthropometric and biochemical indicators of nutritional status of adolescent Mozambican girls

Objective: The objective of the present study was to explore whether dietary patterns (DP) are associated with nutritional status indicators among adolescent Mozambican girls. Design/Setting/Subjects: In this population-based cross-sectional study we used the FFQ data of 547 girls aged 14-19 years from Central Mozambique to derive dietary patterns by means of principal component analysis. We used two-level linear regression models to examine the associations between the DP and anthropometric and biochemical indicators of nutritional status. Results: We identified three DP: 'Urban bread and fats', 'Rural meat and vegetables' and 'Rural cassava and coconut'. The 'Urban bread and fats' DP was positively associated with BMI-for-age Z-score (BMIZ), mid-upper arm circumference (MUAC), triceps skinfold (P for all <0.001) and blood Hb (P = 0.025). A negative association was observed between the 'Urban bread and fats' DP and serum folate (P <0.001). The 'Rural meat and vegetables' DP and the 'Rural cassava and coconut' DP were associated negatively with BMIZ, MUAC and triceps skinfold (P for all <0.05), but the 'Rural meat and vegetables' DP was associated positively with serum ferritin (P = 0.007). Conclusions: Urban and rural DP were associated with nutritional status indicators. In a low-resource setting, urban diets may promote body fat storage and blood Hb concentrations but compromise serum folate concentration. It is important to continue valuing the traditional, rural foods that are high in folate.Peer reviewe

Host-plant availability drives the spatiotemporal dynamics of interacting metapopulations across a fragmented landscape

The dynamics of ecological communities depend partly on species interactions within and among trophic levels. Experimental work has demonstrated the impact of species interactions on the species involved, but it remains unclear whether these effects can also be detected in long-term time series across heterogeneous landscapes. We analyzed a 19-year time series of patch occupancy by the Glanville fritillary butterflyMelitaea cinxia, its specialist parasitoid waspCotesia melitaearum, and the specialist fungal pathogenPodosphaera plantaginisinfectingPlantago lanceolata,a host plant of the Glanville fritillary. These species share a network of more than 4,000 habitat patches in the angstrom land islands, providing a metacommunity data set of unique spatial and temporal resolution. To assess the influence of interactions among the butterfly, parasitoid, and mildew on metacommunity dynamics, we modeled local colonization and extinction rates of each species while including or excluding the presence of potentially interacting species in the previous year as predictors. The metapopulation dynamics of all focal species varied both along a gradient in host plant abundance, and spatially as indicated by strong effects of local connectivity. Colonization and to a lesser extent extinction rates depended also on the presence of interacting species within patches. However, the directions of most effects differed from expectations based on previous experimental and modeling work, and the inferred influence of species interactions on observed metacommunity dynamics was limited. These results suggest that although local interactions among the butterfly, parasitoid, and mildew occur, their roles in metacommunity spatiotemporal dynamics are relatively weak. Instead, all species respond to variation in plant abundance, which may in turn fluctuate in response to variation in climate, land use, or other environmental factors.Peer reviewe