Residential Appraisal and the Lending Process: A Survey of Issues

This article surveys mainly academic literature for issues concerning the use of appraisals in the residential lending process. The development of appraisal methodologies is reviewed, and the strengths and weaknesses of various appraisal techniques are assessed. Issues relating to the use of neighborhood characteristics in appraisals for lending purposes are also explored. Finally, institutional incentives that give rise to biased and self-serving appraisals and possible solutions to these incentive problems are examined.

Combined compressive and shear buckling analysis of hypersonic aircraft structural sandwich panels

The combined-load (compression and shear) buckling equations were established for orthotropic sandwich panels by using the Rayleigh-Ritz method to minimize the panel total potential energy. The resulting combined-load buckling equations were used to generate buckling interaction curves for super-plastically-formed/diffusion-bonded titanium truss-core sandwich panels and titanium honeycomb-core sandwich panels having the same specific weight. The relative combined-load buckling strengths of these two types of sandwich panels are compared with consideration of their sandwich orientations. For square and nearly square panels of both types, the combined load always induces symmetric buckling. As the panel aspect ratios increase, antisymmetric buckling will show up when the loading is shear-dominated combined loading. The square panel (either type) has the highest combined buckling strength, but the combined load buckling strength drops sharply as the panel aspect ratio increases. For square panels, the truss-core sandwich panel has higher compression-dominated combined load buckling strength. However, for shear dominated loading, the square honeycomb-core sandwich panel has higher shear-dominated combined load buckling strength

Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's Disease

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease resulting from the expansion of a glutamine repeat in the huntingtin (Htt) protein. Current therapies are directed at managing symptoms such as chorea and psychiatric disturbances. In an effort to develop a therapy directed at disease prevention we investigated the utility of highly specific, anti-Htt intracellular antibodies (intrabodies). We previously showed that V_(L)12.3, an intrabody recognizing the N terminus of Htt, and Happ1, an intrabody recognizing the proline-rich domain of Htt, both reduce mHtt-induced toxicity and aggregation in cell culture and brain slice models of HD. Due to the different mechanisms of action of these two intrabodies, we then tested both in the brains of five mouse models of HD using a chimeric adeno-associated virus 2/1 (AAV2/1) vector with a modified CMV enhancer/chicken β-actin promoter. V_(L)12.3 treatment, while beneficial in a lentiviral model of HD, has no effect on the YAC128 HD model and actually increases severity of phenotype and mortality in the R6/2 HD model. In contrast, Happ1 treatment confers significant beneficial effects in a variety of assays of motor and cognitive deficits. Happ1 also strongly ameliorates the neuropathology found in the lentiviral, R6/2, N171-82Q, YAC128, and BACHD models of HD. Moreover, Happ1 significantly prolongs the life span of N171-82Q mice. These results indicate that increasing the turnover of mHtt using AAV-Happ1 gene therapy represents a highly specific and effective treatment in diverse mouse models of HD

Quantum polynomial functors from e-Hecke pairs

We define a new category of quantum polynomial functors extending the quantum polynomials introduced by Hong and Yacobi. We show that our category has many properties of the category of Hong and Yacobi and is the natural setting in which one can define composition of quantum polynomial functors. Throughout the paper we highlight several key differences between the theory of classical and quantum polynomial functors