Heat exposure assessment based on individual daily mobility patterns in Dhaka, Bangladesh

Despite a growing body of evidence indicating increasing health impacts from heat exposure secondary to climate change, previous studies have assessed heat exposure based only on the residential locations of individuals. Such assessments may be imprecise as they do not reflect the impact of people's daily mobility patterns. Furthermore, most studies have focused on urban areas in developed countries, whilst relatively little is known about the situation in developing nations, particularly a tropical climate region where heat exposure is severe for residents. As a case study in Dhaka, Bangladesh, we conducted a heat exposure assessment by integrating individual mobility data which was obtained from a questionnaire survey. Estimates of heat exposure were made using remotely sensed land surface temperature data. Population exposures based on residential locations were compared to a dynamic exposure model that incorporated mobility. Especially for people in suburban areas, we found the traditional assessment method based on the static residential model underestimated exposure compared to the dynamic model owing to the fact that some residents migrate into the city center each day where they tend to experience higher temperatures. We found small differences in heat exposure levels between social groups stratified by gender, age, and income based on the dynamic and static models. These results demonstrate that integration of mobility patterns may be important when comparing exposure levels between urban and suburban populations. Our findings may raise issues regarding new remediation measures against urban heat islands, such as reviewing the distribution of health resources or generating a risk map

Vacuum instability in external fields

We study particles creation in arbitrary space-time dimensions by external electric fields, in particular, by fields, which are acting for a finite time. The time and dimensional analysis of the vacuum instability is presented. It is shown that the distributions of particles created by quasiconstant electric fields can be written in a form which has a thermal character and seems to be universal. Its application, for example, to the particles creation in external constant gravitational field reproduces the Hawking temperature exactly.Comment: 36 pages, LaTe

Radiation-Induced Bystander Effects in Cultured Human Stem Cells

The radiation-induced "bystander effect" (RIBE) was shown to occur in a number of experimental systems both in vitro and in vivo as a result of exposure to ionizing radiation (IR). RIBE manifests itself by intercellular communication from irradiated cells to non-irradiated cells which may cause DNA damage and eventual death in these bystander cells. It is known that human stem cells (hSC) are ultimately involved in numerous crucial biological processes such as embryologic development; maintenance of normal homeostasis; aging; and aging-related pathologies such as cancerogenesis and other diseases. However, very little is known about radiation-induced bystander effect in hSC. To mechanistically interrogate RIBE responses and to gain novel insights into RIBE specifically in hSC compartment, both medium transfer and cell co-culture bystander protocols were employed.Human bone-marrow mesenchymal stem cells (hMSC) and embryonic stem cells (hESC) were irradiated with doses 0.2 Gy, 2 Gy and 10 Gy of X-rays, allowed to recover either for 1 hr or 24 hr. Then conditioned medium was collected and transferred to non-irradiated hSC for time course studies. In addition, irradiated hMSC were labeled with a vital CMRA dye and co-cultured with non-irradiated bystander hMSC. The medium transfer data showed no evidence for RIBE either in hMSC and hESC by the criteria of induction of DNA damage and for apoptotic cell death compared to non-irradiated cells (p>0.05). A lack of robust RIBE was also demonstrated in hMSC co-cultured with irradiated cells (p>0.05).These data indicate that hSC might not be susceptible to damaging effects of RIBE signaling compared to differentiated adult human somatic cells as shown previously. This finding could have profound implications in a field of radiation biology/oncology, in evaluating radiation risk of IR exposures, and for the safety and efficacy of hSC regenerative-based therapies

Evaluating the Human Damage of Tsunami at Each Time Frame in Aggregate Units Based on GPS data

Assessments of the human damage caused by the tsunami are required in order to consider disaster prevention at such a regional level. Hence, there is an increasing need for the assessments of human damage caused by earthquakes. However, damage assessments in japan currently usually rely on static population distribution data, such as statistical night time population data obtained from national census surveys. Therefore, human damage estimation that take into consideration time frames have not been assessed yet. With these backgrounds, the objectives of this study are: to develop a method for estimating the population distribution of the for each time frame, based on location positioning data observed with mass GPS loggers of mobile phones, to use a evacuation and casualties models for evaluating human damage due to the tsunami, and evaluate each time frame by using the data developed in the first objective, and 3) to discuss the factors which cause the differences in human damage for each time frame. By visualizing the results, we clarified the differences in damage depending on time frame, day and area. As this study enables us to assess damage for any time frame in and high resolution, it will be useful to consider provision for various situations when an earthquake may hit, such as during commuting hours or working hours and week day or holiday