Role of serum N-terminal pro-brain natriuretic peptide measurement in diagnosis of cardiac involvement in patients with anderson-fabry disease

Enzyme replacement therapy has the potential to delay or reverse adverse cardiac remodeling in Anderson-Fabry disease (AFD); however, the current indications for enzyme replacement therapy rely on detecting relatively advanced features of the disease. We aimed to determine the relation between the serum N-terminal pro-brain natriuretic peptide (NT-proBNP) concentration and cardiac abnormalities in patients with AFD. We hypothesized that it might help to detect early disease. NT-proBNP was measured under at rest conditions in 117 patients with AFD (age 48 ± 15 years, 46.2% men). All patients underwent clinical evaluation with electrocardiography and echocardiography. The median NT-proBNP concentration was 24 pmol/L (range <5 to 6,059). Of the 117 patients, 67 (57%) had elevated, age-corrected, NT-proBNP levels. In the 56 patients (48%) with normal echocardiographic findings, the NT-proBNP levels were greater than the age-predicted cutoffs in 10 of 25 patients with abnormal electrocardiographic findings and 3 of 31 patients with normal electrocardiographic findings (p <0.05). On multiple regression analysis, age, creatinine, left atrial volume index, E/Ea, and the presence of abnormal electrocardiographic findings were independently associated with log NT-proBNP (R(2) = 0.67, p <0.05). In conclusion, NT-proBNP concentrations were elevated in patients with AFD and early cardiac involvement, suggesting its measurement could assist in decisions regarding the timing of enzyme replacement therapy

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS

Evolution of Opinion Mining

The growing availability of the internet and have marked the birth of a new type of society, where people can freely communicate and exchange ideas and opinions. Most of the opinions expressed are unstructured in nature. This gives birth to a new area of research called opinion mining. Opinion mining or sentiment analysis is a new area within the field of text mining, to provide better method in analyzing the unstructured text. The purpose of this paper is to walk through the timeline of opinion mining by identifying the changing direction of scholarly studies in this area. In other words, this study is an attempt to explain the evolution of opinion mining by including some of the significantly contributing papers in this field from the year 1979 to 2011. We have divided the progress into five phases; text interpretation, low-level opinion annotation, difference between subjectivity and objectivity, web data mining applications and lexical resources. This paper will provide academia and researches with insights into past direction and ideas for future research in opinion mining

Comparison between Bag of Words and Word Sense Disambiguation

Bag of Words (BoW) and Word Sense Disambiguation (WSD) are the main approaches utilized in almost every data mining project for classification and data processing. The two approaches are extensively used in constructing various classifiers including supervised, unsupervised and semi-supervised classifiers. In this paper, we introduce new method of defining and comparing between BoW and WSD based on three categories. First, introduce and explain the approaches through the human brain analogy to simplify the overall concept. Secondly, sort their classifiers, methodologies and algorithms in the data mining field. Finally, introduce our developed cognitive miner to illustrate the practical functionality of these two approaches

The Economic Order Quantity in a Fuzzy Environment for a Periodic Inventory Model with Variable Demand

The technique of limiting expenditure plays a critical part in an organization's ability to govern the smooth operation of its management system. The economic order quantity (EOQ) is calculated by solving a nonlinear problem, and the best solution is investigated in a fuzzy and intuitionistic fuzzy environment. The overall cost is made up of several factors, such as demand, holding, and ordering costs. The demand and stock-out characteristics were both fuzzified using fuzzy and intuitionistic fuzzy numbers. The numerical analysis shows the comparison between the two fuzzy numbers through sensitivity analysis

New binuclear Ni(II) metallates containing ONS chelators: synthesis, characterisation, DNA binding, DNA cleavage, protein binding, antioxidant activity, antimicrobial and in vitro cytotoxicity

Four new complexes with bridged bis(diphenylphosphino)ethane containing 3-methoxy salicylaldehyde 4(N)-substituted thiosemicarbazone were prepared and characterised by various spectral and analytical techniques. The new complexes were subjected to study their DNA binding, DNA cleavage, protein binding, antibacterial, antioxidant and cytotoxicity. Distorted square planar geometries of complexes 1 and 4 were evidenced from their crystal structures. The complexes could act as strong binders to CT-DNA and BSA. Furthermore, they cleaved supercoiled DNA pBR322. Good spectra of antibacterial activity against five pathogenic bacteria, namely B. Subtilis, S. Aureus, E. Coli, S. Typhi and S. Aurogenosa, were exhibited by the complexes. All the complexes exhibited good antioxidant activity, which was found to be greater than the conventional standard vitamin C. The complexes showed significantly higher cytotoxicity against human cervical cancer cells (HeLa) and human breast cancer cells (MCF-7) than the standard cisplatin. Furthermore, their non-toxic nature was confirmed when they were tested against human normal keratinocyte cells (HaCaT). The compounds induced ROS (Reactive Oxygen Species)-mediated apoptosis, as indicated by DCFDA (2',7'-dichlorodihydro-fluorescein diacetate) and FACS (Fluorescence Activated Cell Sorting) analyses. The complexes showed remarkable values of <3.4 mu M in MCF-7 and <8.4 mu M in HeLa as compared with 23 mu M for cisplatin with both cell lines

New binuclear Ni(II) metallates as potent antiproliferative agents against MCF-7 and HeLa cells

Four new binuclear nickel(II) metallates 1-4 were synthesized from the reaction between NiCl2 center dot 6H(2)O, 1,3-bis(diphenylphosphino) propane and H2-(MSal-Rtsc)], where R = H, CH3, C2H5, C6H5, MSal = 3-methoxysalicylaldehyde, tsc = thiosemicarbazone. The complexes were characterized by various spectral and analytical methods. Distorted square planar geometry of complexes 3 and 4 were evidenced from their crystal structures. Their binding interaction with calf-thymus DNA (CT DNA) and albumin (Bovine serum albumin) were analyzed with absorption and emission spectral titration studies. Based on the observations, the complexes 1-4 act as strong binders to CT-DNA and BSA. The antioxidant properties of the compounds were evaluated to test their free radical scavenging ability. All the complexes exhibited better antioxidant activity than the ligands and were found to be greater than that of the conventional standard vitamin C. Cell proliferation MTT assays performed for all the compounds in the human breast cancer (MCF-7) and human cervical cancer cell line (HeLa) exposed a significant growth inhibition. The complexes showed remarkably high cytotoxicity against human cervical cancer cells (HeLa) and human breast cancer cells (MCF-7) than the standard cisplatin. Among the four complexes, complex 3 was the most effective against MCF-7 (IC50 value of 4 mu M) and HeLa (2.33 mu M) compared with the other complexes 1 (8.51 mu M; 10.02 mu M), 2 (6.25 mu M; 2.40 mu M) and 4 (6.62 mu M; 4.33 mu M) respectively. Furthermore, the compounds resulted in ROS (reactive oxygen species)-mediated apoptosis, as indicated by DCFDA (2',7'-dichlorodihydro-fluorescein diacetate) and sub-G1 DNA content was measured by fluorescent activated cell sorting (FACS) analysis. (C) 2017 Elsevier B.V. All rights reserved