1,924 research outputs found
Theory of AC Anomalous Hall Conductivity in d-electron systems
To elucidate the intrinsic nature of anomalous Hall effect (AHE) in
-electron systems, we study the AC anomalous Hall conductivity (AHC) in a
tight-binding model with ()-orbitals. We drive a general
expression for the AC AHC , which is valid for finite
quasiparticle damping rate =, and find that the AC AHC is
strongly dependent on . When , the AC AHC shows a spiky peak
at finite energy that originates from the interband particle-hole
excitation, where represents the minimum band-splitting measured from
the Fermi level. In contrast, we find that this spiky peak is quickly
suppressed when is finite. By using a realistic value of
at in -electron systems, the spiky peak
is considerably suppressed. In the present model, the obtained results also
represents the AC spin Hall conductivity in a paramagnetic state.Comment: 13pages, 9 figure
Correlation of high energy muons with primary composition in extensive air shower
An experimental investigation of high energy muons above 200 GeV in extensive air showers has been made for studying high energy interaction and primary composition of cosmic rays of energies in the range 10 to the 14th power approx. 10 to the 15th power eV. The muon energies are estimated from the burst sizes initiated by the muons in the rock, which are measured by four layers of proportional counters, each of area 5 x 2.6 sq m, placed at 30 m.w.e. deep, Funasaka tunnel vertically below the air shower array. These results are compared with Monte Carlo simulations based on the scaling model and the fireball model for two primary compositions, all proton and mixed
Proportional drift tubes for large area muon detectors
A proportional drift chamber which consists of eight rectangular drift tubes with cross section of 10 cm x 5 cm, a sense wire of 100 micron phi gold-plated tungsten wire and the length of 6 m, was tested using cosmic ray muons. Spatial resolution (rms) is between 0.5 and 1 mm over drift space of 50 mm, depending on incident angle and distance from sense wire
Inelastic X-Ray Scattering Study of Exciton Properties in an Organic Molecular crystal
Excitons in a complex organic molecular crystal were studied by inelastic
x-ray scattering (IXS) for the first time. The dynamic dielectric response
function is measured over a large momentum transfer region, from which an
exciton dispersion of 130 meV is observed. Semiempirical quantum chemical
calculations reproduce well the momentum dependence of the measured dynamic
dielectric responses, and thus unambiguously indicate that the lowest Frenkel
exciton is confined within a fraction of the complex molecule. Our results
demonstrate that IXS is a powerful tool for studying excitons in complex
organic molecular systems. Besides the energy position, the IXS spectra provide
a stringent test on the validity of the theoretically calculated exciton wave
functions.Comment: 4 pages, 4 figure
Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector.
A tumor-selective non-lytic retroviral replicating vector (RRV), Toca 511, and an extended-release formulation of 5-fluorocytosine (5-FC), Toca FC, are currently being evaluated in clinical trials in patients with recurrent high-grade glioma (NCT01156584, NCT01470794 and NCT01985256). Tumor-selective propagation of this RRV enables highly efficient transduction of glioma cells with cytosine deaminase (CD), which serves as a prodrug activator for conversion of the anti-fungal prodrug 5-FC to the anti-cancer drug 5-fluorouracil (5-FU) directly within the infected cells. We investigated whether, in addition to its direct cytotoxic effects, 5-FU generated intracellularly by RRV-mediated CD/5-FC prodrug activator gene therapy could also act as a radiosensitizing agent. Efficient transduction by RRV and expression of CD were confirmed in the highly aggressive, radioresistant human glioblastoma cell line U87EGFRvIII and its parental cell line U87MG (U87). RRV-transduced cells showed significant radiosensitization even after transient exposure to 5-FC. This was confirmed both in vitro by a clonogenic colony survival assay and in vivo by bioluminescence imaging analysis. These results provide a convincing rationale for development of tumor-targeted radiosensitization strategies utilizing the tumor-selective replicative capability of RRV, and incorporation of radiation therapy into future clinical trials evaluating Toca 511 and Toca FC in brain tumor patients
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