Multiscale Biofluidic and Nanobiotechnology Approaches for Treating Sepsis in Extracorporeal Circuits

Infectious diseases and their pandemics periodically attract public interests due to difficulty in treating the patients and the consequent high mortality. Sepsis caused by an imbalanced systemic inflammatory response to infection often leads to organ failure and death. The current therapeutic intervention mainly includes "the sepsis bundles," antibiotics (antibacterial, antiviral, and antifungal), intravenous fluids for resuscitation, and surgery, which have significantly improved the clinical outcomes in past decades; however, the patients with fulminant sepsis are still in desperate need of alternative therapeutic approaches. One of the potential supportive therapies, extracorporeal blood treatment, has emerged and been developed for improving the current therapeutic efficacy. Here, I overview how the treatment of infectious diseases has been assisted with the extracorporeal adjuvant therapy and the potential utility of various nanobiotechnology and microfluidic approaches for developing new auxiliary therapeutic methods

Non-competes, business dynamism, and concentration: Evidence from a Florida case study

Most research on non-competes has focused on employees; here we study how non-competes affect firm location choice, growth, and consequent regional concentration, using Florida's 1996 legislative change that eased restrictions on their enforcement. Difference-in-differences models show that following the change, establishments of large firms were more likely to enter Florida; they also created a greater proportion of jobs and increased their share of employment in the state. Entrepreneurs or establishments of small firms, in contrast, were less likely to enter Florida following the law change; they also created a smaller proportion of new jobs and decreased their share of employment. Consistent with these location and job creation dynamics, regional business concentration increased following the law change in Florida. Nationwide cross-sections demonstrate consistent correlations between state-level non-compete enforcement and the location, employment, and concentration dynamics illustrated in Florida

DISTRIBUTION OF INTEGER LATTICE POINTS IN A BALL CENTRED AT A DIOPHANTINE POINT

We study the variance of the fluctuations in the number of lattice points in a ball and in a thin spherical shell of large radius centred at a Diophantine point

Recent trends in particle size analysis techniques

Recent advances and developments in the particle-sizing technologies are briefly reviewed in accordance with three operating principles including particle size and shape descriptions. Significant trends of the particle size analysing equipment recently developed show that compact electronic circuitry and rapid data processing systems were mainly adopted in the instrument design. Some newly developed techniques characterizing the particulate system were also introduced

Optimal Estimates for the Electric Field in Two-Dimensions

The purpose of this paper is to set out optimal gradient estimates for solutions to the isotropic conductivity problem in the presence of adjacent conductivity inclusions as the distance between the inclusions goes to zero and their conductivities degenerate. This difficult question arises in the study of composite media. Frequently in composites, the inclusions are very closely spaced and may even touch. It is quite important from a practical point of view to know whether the electric field (the gradient of the potential) can be arbitrarily large as the inclusions get closer to each other or to the boundary of the background medium. In this paper, we establish both upper and lower bounds on the electric field in the case where two circular conductivity inclusions are very close but not touching. We also obtain such bounds when a circular inclusion is very close to the boundary of a circular domain which contains the inclusion. The novelty of these estimates, which improve and make complete our earlier results published in Math. Ann., is that they give an optimal information about the blow-up of the electric field as the conductivities of the inclusions degenerate.Comment: 26 page

Why Are Wage Profiles so Flat During the First Year on a Job?

This paper presents evidence that productivity net of general training costs rise 4 or 5 times more rapidly than wage rates during the first 2 years on a job. This occurs for three reasons. First, sorting, high job search costs and the reputational damages that result from premature separations cause workers to prefer front loaded compensation packages which reduce the likelihood of involuntary terminations. Second, due to progressive income taxation and poor access to credit, workers discount the future more heavily than employers. Front-loading compensation is, therefore, a relatively cheap way for employers to attract top quality new hires. Finally, the minimum wage and union contracts also tend to force flat wage profiles

Do Some Employers Share the Costs and Benefits of General Training?

[Excerpt] One of the central propositions of the human capital theory of on-the-job training is that workers pay all the costs and receive all the benefits of general training (see Ehrenberg and Smith 1996, Filer, Hammermesh and Rees 1996, Borjas 1996, Kaufman 1986). Since general training raises a worker\u27s ability to be productive in other organizations as well as the one providing the training, the training firm must pay a wage commensurate with the trained worker\u27s new higher level of productivity if they are to prevent the loss of their trained workers. Since the workers, not the firm, get the benefits of the training, firms [will] provide general training only if they [do] not have to pay any of the costs (Becker 1962 p. 13). Since the training is of value to prospective trainees, equilibrium in the training market requires that employees pay for general on-the-job training by receiving wages below what could be received elsewhere (Becker 1962 p. 13) in a job offering no training. Is this correct? Do Workers pay all the costs of training in skills that are technically general (i.e. useful at other firms)--WPAC for short? Do workers receive all the benefits of general training ( WRAB for short)

Applying for Entitlements: Employers and the Targeted Jobs Tax Credit

The Targeted Jobs Tax Credit (TJTC) is probably the most outstanding example of a generous entitlement program with a very low participation rate. Only about 10 percent of eligible youth hired are claimed as a tax credit by their employers. The causes of the low participation rates are analyzed by estimating a Poisson model of the number of TJTC-eligibles hired and certified during 1980, 1981, and 1982. Information costs, both fixed and variable, are found to be key barriers to TJTC participation. The cost- effectiveness of TJTC is low because of the stigma attached and the very high recruitment costs of hiring additional TJTC-eligibles. Because employers find it relatively cheap to certify after the fact eligible new employees who would have been hired anyway, this passive mode of participating in TJTC predominates

Applying for Entitlements: Employers and the Targeted Jobs Tax Credit

The Targeted Jobs Tax Credit is probably the most outstanding example of a generous entitlement program with very low participation rates. Only about 10 percent of eligible youth are claimed. The causes of the low participation rate were analyzed by estimating a poisson model of the number of TJTC eligibles hired and certified during 1980, 1981 and 1982. Information costs, both fixed and variable, were found to be key barriers to TJTC participation. The cost effectiveness of TJTC is low because the stigma and recruitment costs of hiring additional TJTC eligibles are very high. Employers find it relatively cheap to passively certify eligible new hires who would have been hired anyway so this mode of participating in TJTC predominates