A Note on the Use of the Second Vertical Derivative (SVD) of Gravity Data, with Reference to Indonesian Cases

The analysis of gravity data is based, among others, on their horizontal and vertical gradients. Horizontal gradients can be directly estimated from the spatially distributed data, while the vertical derivative can be calculated in either space or wave-number domain. Historically, the Second Vertical Derivative (SVD) of gravity data is known to be able to delineate anomalous sources\u27 boundaries. The paper discusses the incorrect use of the SVD of gravity data, with reference to current practices in Indonesia. The SVD relative magnitude along a profile is often used to define whether a density contrast and its dipping orientation correspond to a normal or reverse fault, which might be geologically incorrect. We exemplify our analysis using both synthetic and field data

Analisis Sistem Tanggap Darurat Kebakaran Di Container Yard 02 Terminal Petikemas PT. Pelabuhan Indonesia III (Persero) Semarang Tahun 2016

Container Yard PT. Pelabuhan Indonesia III Semarang is large port giving services on manual handling container. A fire at the container terminal can cause a great deal of loss as it affects a high value of asset, work process and employment opportunities. One of the effort to decrease the risk and impact due to the fire is the emergency response system. One of efforts to reduce the risk and impact caused by the fires is require the application of non-structural mitigation in multi-storey office building. The purpose of the study is to analyze the emergency response system in the effort to prevent and control a fire disaster at terminal Container Yard 02. This research is a Descriptive Qualitative research with in-depth interviews and yard observation. The subjects of this study consists of 5 people as the main informants and 3 people as informant triangulation. The results show that the management has the commitment and written policy for Occupational Safety and Health, dated and certified by the highest leader atau level. Fire drills training are given to all staffs and the emergency response team. Container Yard 2 has all the facilities in active preventive fire such as APAR and hydrant and safety lives facilities that is the meeting point. The procedure taken in an emergency situation is the scenario in fire simulation. In emergency cases the communication system to inform and request help to the related parties is in place. The conclusion of this study is that in Terminal Container the emergency response is applied, such as fire simulation, socialization of the fire prevention policy and training on fire extinction and victim evacuation

Loss-of-function PTPRD mutations lead to increased STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer

Background Protein tyrosine phosphatase receptor type D (PTPRD) is a putative tumor suppressor in several cancers including head and neck squamous cell carcinoma (HNSCC). STAT3 is a frequently hyperactivated oncogene in HNSCC. As STAT3 is a direct substrate of PTPRD, we sought to determine the genetic or epigenetic alterations of PTPRD that contribute to overactive STAT3 in HNSCC. Methods We analyzed data from The Cancer Genome Atlas (TCGA) and our previous whole-exome sequencing study and summarized the mutation, methylation, and copy number status of PTPRD in HNSCC and other cancers. In vitro studies involved standard transfection and MTT protocols, as well as methylation-specific PCR. Results Our findings indicate that PTPRD mutation, rather thanmethylation or copy number alteration, is the primary mechanism by which PTPRD function is lost in HNSCC.We demonstrate that overexpression of wild-type PTPRD in HNSCC cells significantly inhibits growth and STAT3 activation while PTPRD mutants do not, suggesting thatmutation may lead to loss of function and subsequent hyper-phosphorylation of PTPRD substrates, especially STAT3. Importantly, we determined that HNSCC cells harboring an endogenous PTPRD mutation are more sensitive to STAT3 blockade than PTPRD wild-type cells.We additionally found that PTPRD mRNA expression does not correlate with pSTAT3 expression, suggesting that alterations that manifest through altered mRNA expression, including hypermethylation and gene copy number alterations, do not significantly contribute to STAT3 overactivation in HNSCC. Copyright

Methodology of a Natural History Study of a Rare Neurodevelopmental Disorder: Alternating Hemiplegia of Childhood as a Prototype Disease

Here, we describe the process of development of the methodology for an international multicenter natural history study of alternating hemiplegia of childhood as a prototype disease for rare neurodevelopmental disorders. We describe a systematic multistep approach in which we first identified the relevant questions about alternating hemiplegia of childhood natural history and expected challenges. Then, based on our experience with alternating hemiplegia of childhood and on pragmatic literature searches, we identified solutions to determine appropriate methods to address these questions. Specifically, these solutions included development and standardization of alternating hemiplegia of childhood-specific spell video-library, spell calendars, adoption of tailored methodologies for prospective measurement of nonparoxysmal and paroxysmal manifestations, unified data collection protocols, centralized data platform, adoption of specialized analysis methods including, among others, Cohen kappa, interclass correlation coefficient, linear mixed effects models, principal component, propensity score, and ambidirectional analyses. Similar approaches can, potentially, benefit in the study of other rare pediatric neurodevelopmental disorders

Forecasting the constraints on optical selection bias and projection effects of galaxy cluster lensing with multiwavelength data

Galaxy clusters identified with optical imaging tend to suffer from projection effects, which impact richness (the number of member galaxies in a cluster) and lensing coherently. Physically unassociated galaxies can be mistaken as cluster members due to the significant uncertainties in their line-of-sight distances, thereby changing the observed cluster richness; at the same time, projection effects alter the weak gravitational lensing signals of clusters, leading to a correlated scatter between richness and lensing at a given halo mass. As a result, the lensing signals for optically selected clusters tend to be biased high. This optical selection bias problem of cluster lensing is one of the key challenges in cluster cosmology. Fortunately, recently available multiwavelength observations of clusters provide a solution. We analyze a simulated data set mimicking the observed lensing of clusters identified by both optical photometry and gas properties, aiming to constrain this selection bias. Assuming a redMaPPer sample from the Dark Energy Survey with South Pole Telescope Sunyaev-Zeldovich effect observations, we find that an overlapping survey of 1300 square deg, 0.2 < z < 0.65, can constrain the average lensing bias to an accuracy of 5 percent. This provides an exciting opportunity for directly constraining optical selection bias from observations. We further show that our approach can remove the optical selection bias from the lensing signal, paving the way for future optical cluster cosmology analyses.Comment: 16 pages, 5 figures. Submitted to PR

Understanding the small object argument

The small object argument is a transfinite construction which, starting from a set of maps in a category, generates a weak factorisation system on that category. As useful as it is, the small object argument has some problematic aspects: it possesses no universal property; it does not converge; and it does not seem to be related to other transfinite constructions occurring in categorical algebra. In this paper, we give an "algebraic" refinement of the small object argument, cast in terms of Grandis and Tholen's natural weak factorisation systems, which rectifies each of these three deficiencies.Comment: 42 pages; supersedes the earlier arXiv preprint math/0702290; v2: final journal version, minor corrections onl

The non-coding landscape of head and neck squamous cell carcinoma

published_or_final_versio

The eROSITA Final Equatorial-Depth Survey (eFEDS): X-ray properties of Subaru optically-selected clusters

We present the results of a systematic X-ray analysis of optically rich galaxy clusters detected by the Subaru HSC survey in the eROSITA eFEDS field. Through a joint analysis of SRG/eROSITA and Subaru/HSC surveys, we aim to study the dynamical status of the optically selected clusters and derive the cluster scaling relations. The sample consists of 43 optically selected galaxy clusters with a richness $>40$ in $0.16<z<0.89$. We systematically analyzed the X-ray images and spectra using the eROSITA data. We identified the BCG using the optical and far-infrared databases. We evaluated the cluster's dynamical status by measuring the offset between the X-ray peak and BCG position, the gas concentration, and the number of galaxy-density peaks. We studied the luminosity-temperature and mass-luminosity relations based on eROSITA X-ray spectra and HSC weak-lensing data analyses. Based on the these measurements, the fraction of relaxed clusters is $2(<39)$%, which is smaller than that of the X-ray-selected cluster samples. After correcting for a selection bias due to the richness cut, we obtained a shallow $L-T$ slope of $2.1\pm0.5$, which is consistent with the predictions of the self-similar model and the baseline model incorporating a mass-concentration relation. The $L-M$ slope of $1.5\pm0.3$ agrees with the above theoretical models and that of the shear-selected clusters in the eFEDs field. Our analysis of high-richness optical clusters yields a small fraction of relaxed clusters and a shallow slope for the luminosity-temperature relation. This suggests that the average X-ray properties of the optical clusters are likely to be different from those observed in the X-ray samples. Thus, the joint eROSITA and HSC observations are a powerful tool in extending the analysis to a larger sample and understanding the selection effect with a view to establish cluster scaling relations.Comment: 12 pages, 4 figures, A&A accepted, minor correctio