Functional Maps Representation on Product Manifolds

We consider the tasks of representing, analyzing and manipulating maps between shapes. We model maps as densities over the product manifold of the input shapes; these densities can be treated as scalar functions and therefore are manipulable using the language of signal processing on manifolds. Being a manifold itself, the product space endows the set of maps with a geometry of its own, which we exploit to define map operations in the spectral domain; we also derive relationships with other existing representations (soft maps and functional maps). To apply these ideas in practice, we discretize product manifolds and their Laplace--Beltrami operators, and we introduce localized spectral analysis of the product manifold as a novel tool for map processing. Our framework applies to maps defined between and across 2D and 3D shapes without requiring special adjustment, and it can be implemented efficiently with simple operations on sparse matrices.Comment: Accepted to Computer Graphics Foru

Peripheral blood lymphocyte proviral DNA predicts neurocognitive impairment in clade C HIV

CITATION: Ruhanya, V. et al. 2020. Peripheral blood lymphocyte proviral DNA predicts neurocognitive impairment in clade C HIV. Journal of NeuroVirology, 26:920–928, doi:10.1007/s13365-020-00882-9.The original publication is available at https://link.springer.comIt is not known if proviral DNA in the periphery corresponds to cognitive status in clade C as it does in clade B and recombinant forms. A cross-sectional study was conducted on participants investigated for HIV-associated neurocognitive impairment in South Africa. HIV-1 proviral DNA was quantified using a PCR assay targeting a highly conserved HIV-1 LTR-gag region. Fifty-four (36.7%) participants were cognitively impaired and 93 (63.3%) were not impaired. Forty-three (79.6%) of the cognitively impaired participants were female and 11 (20.4%) were male. There was no significant age difference between cognitively impaired and unimpaired participants (p = 0.42). HIV-1 DNA in cognitively impaired PLWH was significantly higher than in cognitively normal individuals (p = .016). Considering impaired participants, lymphocyte HIV-1 DNA was significantly higher in males than females (p = 0.02). There was a modest positive correlation between lymphocyte HIV-1 DNA and global deficit scores (GDS) r = 0.176; p = 0.03). The two measures of viral load, lymphocyte HIV-1 DNA copies/million and plasma RNA copies/ml, were positively correlated (r = 0.39; p < .001). After adjusting for other covariates, age, sex, treatment status, and the interactions between impairment and treatment, the multivariate regression showed association between proviral load and neurocognitive impairment; omega effect size was 0.04, p value = 0.010. The burden of HIV-1 peripheral blood lymphocyte proviral DNA corresponds to neurocognitive impairment among individuals infected with clade C disease. Therefore, therapeutic strategies to reduce the HIV-1 proviral DNA reservoir in lymphocytes may improve neurocognitive outcomes in PLWH.Poliomyelitis Research Foundation (PRF)National Research Foundation (NRF)South African Medical Research Council (SAMRC)Publisher's versio

Relaxed Cutting Plane Method for Solving Linear Semi-Infinite Programming Problems

One of the major computational tasks of using the traditional cutting plane approach to solve linear semi-infinite programming problems lies in finding a global optimizer of a nonlinear and nonconvex program. This paper generalizes the Gustafson and Kortanek scheme to relax this requirement. In each iteration, the proposed method chooses a point at which the infinite constraints are violated to a degree, rather than a point at which the violations are maximized. A convergence proof of the proposed scheme is provided. Some computational results are included. An explicit algorithm which allows the unnecessary constraints to be dropped in each iteration is also introduced to reduce the size of computed programs.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45251/1/10957_2004_Article_411711.pd

Modulation of apoptosis of CD4+ T cells from HIV-infected individuals with the neurotransmitter vasoactive intestinal peptide (VIP) and other biomediators

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PLATELET FLOW CYTOMETRY AND MARKERS OF IMMUNE ACTIVATION IN ASYMPTOMATIC, TREATMENT- NA�VE HIV INFECTION

Geneeskunde en GesondheidswetenskappeGeneeskundige VirologiePlease help us populate SUNScholar with the post print version of this article. It can be e-mailed to: [email protected]

Myeloperoxidase and MPXI as markers of inflammation in asymptomatic HIV-1 infection. Virology Africa 2011.

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The VIP receptor VPAC2 on CD4T cells as a novel marker of immune activation in HIV infection and potential target for immune modulation. 6th International AIDS Society (IAS) Conference on HIV Pathogenesis and treatment; 2011.

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Pheynotypic characterization of Blood dendritic cells in chronically HIV-infected individuals in South Africa. Virology Africa 2011.

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