Divergent roles of CprK paralogues from Desulfitobacterium hafniense in activating gene expression

Gene duplication and horizontal gene transfer play an important role in the evolution of prokaryotic genomes. We have investigated the role of three CprK paralogues from the cAMP receptor protein-fumarate and nitrate reduction regulator (CRP-FNR) family of transcriptional regulators that are encoded in the genome of Desulfitobacterium hafniense DCB-2 and possibly regulate expression of genes involved in the energy-conserving terminal reduction of organohalides (halorespiration). The results from in vivo and in vitro promoter probe assays show that two regulators (CprK1 and CprK2) have an at least partially overlapping effector specificity, with preference for ortho-chlorophenols, while meta-chlorophenols proved to be effectors for CprK4. The presence of a potential transposase-encoding gene in the vicinity of the cprK genes indicates that their redundancy is probably caused by mobile genetic elements. The CprK paralogues activated transcription from promoters containing a 14 bp inverted repeat (dehalobox) that closely resembles the FNR-box. We found a strong negative correlation between the rate of transcriptional activation and the number of nuclecitide changes from the optimal dehalobox sequence (TTAAT-N-4-ATTAA). Transcription was initiated by CprK4 from a promoter that is situated upstream of a gene encoding a methyl-accepting chemotaxis protein. This might be the first indication of taxis of an anaerobic bacterium to halogenated aromatic compounds

A Risk Comparison of Ordinary Least Squares vs Ridge Regression

We compare the risk of ridge regression to a simple variant of ordinary least squares, in which one simply projects the data onto a finite dimensional subspace (as specified by a Principal Component Analysis) and then performs an ordinary (un-regularized) least squares regression in this subspace. This note shows that the risk of this ordinary least squares method is within a constant factor (namely 4) of the risk of ridge regression.Comment: Appearing in JMLR 14, June 201

Thermodynamic Properties of Generalized Exclusion Statistics

We analytically calculate some thermodynamic quantities of an ideal $g$-on gas obeying generalized exclusion statistics. We show that the specific heat of a $g$-on gas ($g \neq 0$) vanishes linearly in any dimension as $T \to 0$ when the particle number is conserved and exhibits an interesting dual symmetry that relates the particle-statistics at $g$ to the hole-statistics at $1/g$ at low temperatures. We derive the complete solution for the cluster coefficients $b_l(g)$ as a function of Haldane's statistical interaction $g$ in $D$ dimensions. We also find that the cluster coefficients $b_l(g)$ and the virial coefficients $a_l(g)$ are exactly mirror symmetric ($l$=odd) or antisymmetric ($l$=even) about $g=1/2$. In two dimensions, we completely determine the closed forms about the cluster and the virial coefficients of the generalized exclusion statistics, which exactly agree with the virial coefficients of an anyon gas of linear energies. We show that the $g$-on gas with zero chemical potential shows thermodynamic properties similar to the photon statistics. We discuss some physical implications of our results.Comment: 24 pages, Revtex, Corrected typo

Transition from phase to generalized synchronization in time-delay systems

The notion of phase synchronization in time-delay systems, exhibiting highly non-phase-coherent attractors, has not been realized yet even though it has been well studied in chaotic dynamical systems without delay. We report the identification of phase synchronization in coupled nonidentical piece-wise linear and in coupled Mackey-Glass time-delay systems with highly non-phase-coherent regimes. We show that there is a transition from non-synchronized behavior to phase and then to generalized synchronization as a function of coupling strength. We have introduced a transformation to capture the phase of the non-phase coherent attractors, which works equally well for both the time-delay systems. The instantaneous phases of the above coupled systems calculated from the transformed attractors satisfy both the phase and mean frequency locking conditions. These transitions are also characterized in terms of recurrence based indices, namely generalized autocorrelation function $P(t)$, correlation of probability of recurrence (CPR), joint probability of recurrence (JPR) and similarity of probability of recurrence (SPR). We have quantified the different synchronization regimes in terms of these indices. The existence of phase synchronization is also characterized by typical transitions in the Lyapunov exponents of the coupled time-delay systems.Comment: Accepted for publication in CHAO

Mobile phone dependence, social support and impulsivity in Chinese university students

This study examined the frequency of mobile phone dependence in Chinese university students and explored its association with social support and impulsivity. Altogether, 909 university students were consecutively recruited from a large university in China. Mobile phone use, mobile phone dependence, impulsivity, and social support were measured with standardized instruments. The frequency of possible mobile phone use and mobile phone dependence was 78.3% and 7.4%, respectively. Multinomial logistic regression analyses revealed that compared with no mobile phone dependence, possible mobile phone dependence was significantly associated with being male (p = 0.04, OR = 0.7, 95% CI: 0.4–0.98), excessive mobile phone use (p \u3c 0.001, OR = 1.2, 95% CI: 1.09–1.2), and impulsivity (p \u3c 0.001, OR = 1.05, 95% CI: 1.03–1.06), while mobile phone dependence was associated with length of weekly phone use (p = 0.01, OR = 2.5, 95% CI: 1.2–5.0), excessive mobile phone use (p \u3c 0.001, OR = 1.3, 95% CI: 1.2–1.4), and impulsivity (p \u3c 0.001, OR = 1.08, 95% CI: 1.05–1.1). The frequency of possible mobile phone dependence and mobile phone dependence was high in this sample of Chinese university students. A significant positive association with impulsivity was found, but not with social support