Resveratrol and related compounds as antioxidants with an allosteric mechanism of action in epigenetic drug targets

Summary The present review is intended to focus on naturally occurring cytoprotective agents such as resveratrol (trans-3,4',5

Estimating Seasonal Moving Average Model Using Bayesian Approach

This paper utilizes the Gibbs sampling technique to develop a Bayesian inference for Seasonal Moving Average (SMA) model, which includes parameters that distinguish between Multiplicative and Non-multiplicative models (referred to as Augmented Seasonal Moving Average hereafter). The construction of Bayesian inference involves several steps. Firstly, the method of Non-linear least squares (NLS) is used to estimate unknown lagged errors, allowing for the approximation of the complex likelihood function. Secondly, both a semi-conjugate prior distribution and a non- informative prior distribution are applied to the unknown parameters and initial errors. Thirdly, the prior distributions are combined with the approximated likelihood function to obtain the joint posterior distribution. Lastly, the full conditional distributions are derived as part of the Gibbs sampling process. The proposed method is notable for its simplicity in assessing the significance of the parameters that distinguish between Multiplicative and Non-multiplicative models, a task that is challenging to accomplish using classical analysis. The convergence of the method was verified, ensuring that it reached stable and reliable results

Effect of FK 506 chronic administration on bromosulphthalein hepatic excretion in rats

There are several reports dealing with the hepatic effect of FK 506,1–4 some of which are beneficial while others are adverse. Because the liver is a major target organ that is often the site of drug toxicity, studies directed at determining whether FK 506 affects specific hepatic function and/or its histologic appearance are important. Therefore, the present study was undertaken to examine bromosulphthalein (BSP) elimination kinetics in rats as a sensitive index of hepatic excretory function under the influence of FK 506 in the rat

31p-NMR spectroscopy of rat liver during simple storage or continuous hypothermic perfusion

The ATP content and intracellular pH (pH(i)) of isolated rat liver before, during, and after cold preservation in either UW-lactobionate (UW, n=10) or Euro-Collins (EC, n=8) solutions were monitored using phosphorus-31 nuclear magnetic resonance ((31)P-NMR) spectroscopy. The (31)P-NMR spectra were obtained on a 4.7-Tesla system operating at 81 MHz. Fructose metabolism, liver enzyme release, O(2) consumption, and rat survival after liver transplantation were also evaluated. During simple cold storage (SCS), the ATP level declined to undetectable levels with both preservation solutions while the pH(i) declined to approximately 7.0. In contrast, during continuous hypothermic perfusion (CHP), hepatic ATP levels remained measurable during the 24-hour EC preservation and actually increased significantly (p>0.01) during UW preservation. After reperfusion at 37°C with Krebs-lactate, the SCS livers treated with EC differed significantly from the UW livers in terms of their ATP and pH(i) as well as their response to a fructose challenge. In contrast, livers undergoing CHP demonstrated similar behaviors with both solutions. These results demonstrate an increase in the hepatic ATP content during CHP which occurs with UW but is not seen with EC. On the other hand, only livers that were simply stored with UW achieved significant survival after transplant, while CHP livers were affected by vascular damage as demonstrated by fatal thrombosis after transplant. These data suggest that ATP content is not the only determinant of good liver function although a system of hypothermic perfusion might further improve liver preservation efficacy should injury to vascular endothelium be avoided