There are several reports dealing with the hepatic effect of FK 506,1–4 some of which are
beneficial while others are adverse. Because the liver is a major target organ that is often the
site of drug toxicity, studies directed at determining whether FK 506 affects specific hepatic
function and/or its histologic appearance are important. Therefore, the present study was
undertaken to examine bromosulphthalein (BSP) elimination kinetics in rats as a sensitive
index of hepatic excretory function under the influence of FK 506 in the rat