Nicotine absorption from e-cigarettes over 12 months

Background Research indicates that, over time, exclusive e-cigarette users (vapers) gradually reduce the nicotine concentration in their e-liquid and transition to more sophisticated devices. Alongside this, consumption of e-liquid increases and constant cotinine levels are maintained. Aims We aimed to confirm these observations in 27 experienced vapers tested at baseline and 12 months later, by measuring nicotine absorption (via salivary levels of the nicotine metabolite cotinine; ng/mL), nicotine concentrations in e-liquid (mg/mL), volume of e-liquid consumed (mL per day), device types and flavours used, both at baseline and 12 months. Results Vapers reduced both their nicotine concentrations in e-liquid over 12 months (from 13.83 mg/mL at baseline to 9.91 at follow up) but significantly increased their e-liquid consumption (from 4.44 to 6.84 mL). No significant changes in salivary cotinine concentrations (370.88 ng/mL at baseline and 415.78 ng/mL at follow up) were observed. There was an increase in sub-ohming (using an atomiser coil with resistance of <1 Ω with increased power) at 12 months, and in the use of fruit flavoured e-liquids. Conclusions Our sample of experienced vapers reduced the concentration of nicotine in their e-liquid over time, but maintained their nicotine intake possibly through self-titration via more intensive puffing. Findings suggest there may be little benefit in reducing nicotine e-liquid concentration since this appears to result in higher e-liquid consumption which may incur both a financial and health cost. Gaining an understanding of underlying reasons for lowering e-liquid concentration would be a useful line of empirical enquiry

The embryonic development of the California Gull

journal articleThe California gull (Larus califomicus) is a summer resident in Utah nesting commonly on certain islands in Great Salt Lake as well as at man-made refuges on the east side of the lake. Many aspects of the biology of the species have been investigated (Beck, 1942; Behle, 1958; Behle and Goates, 1957; Behle and Woodbury, 1952; Greenhalgh, 1952; Johnston, 1956; Odin, 1957; Woodbury, Behle and Sugden, 1946) and it seemed that an opportunity was presented to study yet another feature, namely, the early embryonic development. This conviction was strengthened when it was noted in Romanoff's (1960) extensive work on the avian embryo that whereas there is mention of embryological studies on some species of gulls of the genus Larus, the California gull was not included. Furthermore, no study of the gross external anatomy of any gull seemed to have been made; rather the studies had been histological investigations of the internal anatomy

A Memetic Analysis of a Phrase by Beethoven: Calvinian Perspectives on Similarity and Lexicon-Abstraction

This article discusses some general issues arising from the study of similarity in music, both human-conducted and computer-aided, and then progresses to a consideration of similarity relationships between patterns in a phrase by Beethoven, from the first movement of the Piano Sonata in A flat major op. 110 (1821), and various potential memetic precursors. This analysis is followed by a consideration of how the kinds of similarity identified in the Beethoven phrase might be understood in psychological/conceptual and then neurobiological terms, the latter by means of William Calvin’s Hexagonal Cloning Theory. This theory offers a mechanism for the operation of David Cope’s concept of the lexicon, conceived here as a museme allele-class. I conclude by attempting to correlate and map the various spaces within which memetic replication occurs

The Entropy Principle and the Influence of Sociological Pressures on SETI

We begin with the premise that the law of entropy could prove to be fundamental for the evolution of intelligent life and the advent of technological civilization. Building on recent theoretical results, we combine a modern approach to evolutionary theory with Monte Carlo Realization Techniques. A numerical test for a proposed significance of the law of entropy within the evolution of intelligent species is performed and results are compared with a neutral test hypothesis. Some clarifying aspects on the emergence of intelligent species arise and are discussed in the framework of contemporary astrobiology.Comment: 11 pages, 5 figures, accepted for publication in the International Journal of Astrobiolog

Changing Behaviour: Electronic Cigarettes

Smoking is one of the largest causes of death and disease in the developed world, responsible for 96,000 deaths per year in the UK1. If current trends continue, it is estimated that globally, a billion lives will be lost to smoking-related diseases by the end of the 21st Century2. This briefing summarises the facts and figures around smoking cessation and the use of e-cigarettes for behaviour change in adults followed by public policy recommendations to facilitate smoking cessation

Dispersive Optical Interface Based on Nanofiber-Trapped Atoms

We dispersively interface an ensemble of one thousand atoms trapped in the evanescent field surrounding a tapered optical nanofiber. This method relies on the azimuthally-asymmetric coupling of the ensemble with the evanescent field of an off-resonant probe beam, transmitted through the nanofiber. The resulting birefringence and dispersion are significant; we observe a phase shift per atom of $\sim$\,1\,mrad at a detuning of six times the natural linewidth, corresponding to an effective resonant optical density per atom of 0.027. Moreover, we utilize this strong dispersion to non-destructively determine the number of atoms.Comment: 4 pages, 4 figure

Awe and Wonder in Scientific Practice: Implications for the Relationship Between Science and Religion

This paper examines the role of awe and wonder in scientific practice. Drawing on evidence from psychological research and the writings of scientists and science communicators, I argue that awe and wonder play a crucial role in scientific discovery. They focus our attention on the natural world, encourage open-mindedness, diminish the self (particularly feelings of self-importance), help to accord value to the objects that are being studied, and provide a mode of understanding in the absence of full knowledge. I will flesh out implications of the role of awe and wonder in scientific discovery for debates on the relationship between science and religion. Abraham Heschel argued that awe and wonder are religious emotions because they reduce our feelings of self-importance, and thereby help to cultivate the proper reverent attitude towards God. Yet metaphysical naturalists such as Richard Dawkins insist that awe and wonder need not lead to any theistic commitments for scientists. The awe some scientists experience can be regarded as a form of non-theistic spirituality, which is neither a reductive naturalism nor theism. I will attempt to resolve the tension between these views by identifying some common ground

Frustrations of fur-farmed mink

Captive animals may suffer if strongly motivated to perform activities that their housing does not allow. We investigated this experimentally for caged mink, and found that they would pay high costs to perform a range of natural behaviours, and release cortisol if their most preferred activity, swimming, was prevented. Investigates the effect of limitations on caged mink. Popularity of fur farming; Research into the possible deprivation of mink, which result in their frustration; Details of the experiment; Impact of an access to water; Results which indicate that fur-farmed mink are still motivated to perform the same activities as their wild counterpart

Optical interface created by laser-cooled atoms trapped in the evanescent field surrounding an optical nanofiber

Trapping and optically interfacing laser-cooled neutral atoms is an essential requirement for their use in advanced quantum technologies. Here we simultaneously realize both of these tasks with cesium atoms interacting with a multi-color evanescent field surrounding an optical nanofiber. The atoms are localized in a one-dimensional optical lattice about 200 nm above the nanofiber surface and can be efficiently interrogated with a resonant light field sent through the nanofiber. Our technique opens the route towards the direct integration of laser-cooled atomic ensembles within fiber networks, an important prerequisite for large scale quantum communication schemes. Moreover, it is ideally suited to the realization of hybrid quantum systems that combine atoms with, e.g., solid state quantum devices