Heat transfer to a gas containing a cloud of particles

Heat transfer to gas containing particle clou

Using prospective methods to identify fieldwork locations favourable to understand divergences in health care accessibility

Central to this article is the issue of choosing sites for where a fieldwork could provide a better understanding of divergences in health care accessibility. Access to health care is critical to good health, but inhabitants may experience barriers to health care limiting their ability to obtain the care they need. Most inhabitants of low-income countries need to walk long distances along meandering paths to get to health care services. Individuals in Malawi responded to a survey with a battery of questions on perceived difficulties in accessing health care services. Using both vertical and horizontal impedance, we modelled walking time between household locations for the individuals in our sample and the health care centres they were using. The digital elevation model and Tobler’s hiking function were used to represent vertical impedance, while OpenStreetMap integrated with land cover map were used to represent horizontal impedance. Combining measures of walking time and perceived accessibility in Malawi, we used spatial statistics and found spatial clusters with substantial discrepancies in health care accessibility, which represented fieldwork locations favourable for providing a better understanding of barriers to health access.publishedVersio

The evil circle of poverty: a qualitative study of malaria and disability

<p>Abstract</p> <p>Background</p> <p>This article discusses the link between disability and malaria in a poor rural setting. Global malaria programmes and rehabilitation programmes are organized as vertical and separate programmes, and as such they focus on prevention, cure and control, and disability respectively. When looking at specific conditions and illnesses, the impairing long-term consequences of illness incidents during childhood are not questioned.</p> <p>Methods</p> <p>The study design was ethnographic with an open, exploratory approach. Data were collected in Mangochi District in Malawi through qualitative in-depth interviews and participant observation.</p> <p>Results</p> <p>Despite a local-based health service system, people living in poor rural areas are confronted with a multitude of barriers when accessing malaria prevention and treatment. Lack of skilled health personnel and equipment add to the general burden of poverty: insufficient knowledge about health care, problems connected to accessing the health facility in time, insufficient initiatives to prevent malaria attacks, and a general lack of attention to the long term disabling effects of a malaria attack.</p> <p>Conclusions</p> <p>This study points to the importance of building malaria programmes, research and statistics that take into consideration the consequences of permanent impairment after a malaria attack, as well as the context of poverty in which they often occur. In order to do so, one needs to develop methods for detecting people whose disabilities are a direct result of not having received health services after a malaria episode. This may be done through qualitative approaches in local communities and should also be supplemented by suitable surveys in order to estimate the problem on a larger scale.</p

Discovery of an optical counterpart to the hyperluminous X-ray source in ESO 243-49

The existence of black holes of masses ~ 10^2-10^5 Msun has important implications for the formation and evolution of star clusters and supermassive black holes. One of the strongest candidates to date is the hyperluminous X-ray source HLX1, possibly located in the S0-a galaxy ESO243-49, but the lack of an identifiable optical counterpart had hampered its interpretation. Using the Magellan telescope, we have discovered an unresolved optical source with R = (23.80 +/- 0.25) mag and V = (24.5 +/- 0.3) mag within HLX1's positional error circle. This implies an average X-ray/optical flux ratio ~ 500. Taking the same distance as ESO243-49, we obtain an intrinsic brightness M_R = (-11.0 +/- 0.3) mag, comparable to that of a massive globular cluster. Alternatively, the optical source is consistent with a main-sequence M star in the Galactic halo (for example an M4.4 star at ~ 2.5 kpc). We also examined the properties of ESO243-49 by combining Swift/UVOT observations with stellar population modelling. We found that the overall emission is dominated by a ~5 Gyr old stellar population, but the UV emission at ~2000 Ang is mostly due to ongoing star-formation at a rate of ~ 0.03 Msun/yr. The UV emission is more intense (at least a 9-sigma enhancement above the mean) North East of the nucleus, in the same quadrant as HLX1. With the combined optical and X-ray measurements, we put constraints on the nature of HLX1. We rule out a foreground star and a background AGN. Two alternative scenarios are still viable. HLX1 could be an accreting intermediate-mass black hole in a star cluster, which may itself be the stripped nucleus of a dwarf galaxy that passed through ESO243-49, an event which might have caused the current episode of star formation. Or, it could be a neutron star in the Galactic halo, accreting from an M4-M5 donor star.Comment: 7 pages, accepted by MNRAS. Several improvements from Oct 7 version: stronger evidence of the optical counterpart; more accurate estimate of its brightness (a factor of 2 brighter than previously estimated); use of a larger set of Swift/UVOT data to measure the recent star formation rate in ESO243-49; improved discussion and comparison of the competing scenario

Nitric oxide suppresses cerebral vasomotion by sGC-independent effects on ryanodine receptors and voltage-gated calcium channels

Background/Aims: In cerebral arteries, nitric oxide (NO) release plays a key role in suppressing vasomotion. Our aim was to establish the pathways affected by NO in rat middle cerebral arteries. Methods: In isolated segments of artery, isometric tension and simultaneous measurements of either smooth muscle membrane potential or intracellular [Ca 2+ ] ([Ca 2+ ] SMC ) changes were recorded. Results: In the absence of L -NAME, asynchronous propagating Ca 2+ waves were recorded that were sensitive to block with ryanodine, but not nifedipine. L -NAME stimulated pronounced vasomotion and synchronous Ca 2+ oscillations with close temporal coupling between membrane potential, tone and [Ca 2+ ] SMC . If nifedipine was applied together with L -NAME, [Ca 2+ ] SMC decreased and synchronous Ca 2+ oscillations were lost, but asynchronous propagating Ca 2+ waves persisted. Vasomotion was similarly evoked by either iberiotoxin, or by ryanodine, and to a lesser extent by ODQ. Exogenous application of NONOate stimulated endothelium-independent hyperpolarization and relaxation of either L -NAME-induced or spontaneous arterial tone. NO-evoked hyperpolarization involved activation of BK Ca channels via ryanodine receptors (RYRs), with little involvement of sGC. Further, in whole cell mode, NO inhibited current through L-type voltage-gated Ca 2+ channels (VGCC), which was independent of both voltage and sGC. Conclusion: NO exerts sGC-independent actions at RYRs and at VGCC, both of which normally suppress cerebral artery myogenic tone

From transcriptome to biological function: environmental stress in an ectothermic vertebrate, the coral reef fish Pomacentrus moluccensis

BackgroundOur understanding of the importance of transcriptional regulation for biological function is continuously improving. We still know, however, comparatively little about how environmentally induced stress affects gene expression in vertebrates, and the consistency of transcriptional stress responses to different types of environmental stress. In this study, we used a multi-stressor approach to identify components of a common stress response as well as components unique to different types of environmental stress. We exposed individuals of the coral reef fish Pomacentrus moluccensis to hypoxic, hyposmotic, cold and heat shock and measured the responses of approximately 16,000 genes in liver. We also compared winter and summer responses to heat shock to examine the capacity for such responses to vary with acclimation to different ambient temperatures.ResultsWe identified a series of gene functions that were involved in all stress responses examined here, suggesting some common effects of stress on biological function. These common responses were achieved by the regulation of largely independent sets of genes; the responses of individual genes varied greatly across different stress types. In response to heat exposure over five days, a total of 324 gene loci were differentially expressed. Many heat-responsive genes had functions associated with protein turnover, metabolism, and the response to oxidative stress. We were also able to identify groups of co-regulated genes, the genes within which shared similar functions.ConclusionThis is the first environmental genomic study to measure gene regulation in response to different environmental stressors in a natural population of a warm-adapted ectothermic vertebrate. We have shown that different types of environmental stress induce expression changes in genes with similar gene functions, but that the responses of individual genes vary between stress types. The functions of heat-responsive genes suggest that prolonged heat exposure leads to oxidative stress and protein damage, a challenge of the immune system, and the re-allocation of energy sources. This study hence offers insight into the effects of environmental stress on biological function and sheds light on the expected sensitivity of coral reef fishes to elevated temperatures in the future

A New Empirical Model for the Structural Analysis of Early-type Galaxies and a Critical Review of the Nuker Model

The Nuker law was designed to match the inner few (~3-10) arcseconds of predominantly nearby (< 30 Mpc) early-type galaxy light-profiles; it was never intended to describe an entire profile. The Sersic model, on the other hand, was developed to fit the entire profile; however, due to the presence of partially depleted galaxy cores, the Sersic model cannot always describe the very inner region. We have therefore developed a new empirical model consisting of an inner power-law, a transition region, and an outer Sersic model to connect the inner and outer structure of elliptical galaxies. Moreover, the stability of the Nuker model parameters are investigated. Surprisingly, none are found to be stable quantities; all are shown to vary systematically with a profile's fitted radial extent, and often by more than 100%. Considering elliptical galaxies spanning a range of 7.5 magnitudes, the central stellar density of the underlying host galaxy is observed to increase with galaxy luminosity until the onset of core formation, detected only in the brightest elliptical galaxies. We suggest that the so-called ``power-law'' galaxies may actually be described by the Sersic model over their entire radial range

Cannabidiol (CBD) improves survival and behavioural comorbidities of Dravet syndrome in mice

Background and Purpose Dravet syndrome is a severe, genetic form of paediatric epilepsy associated with premature mortality and comorbidities such as anxiety, depression, autism, motor dysfunction, and memory deficits. Cannabidiol is an approved anticonvulsive drug in USA and Europe for seizures associated with Dravet syndrome therapy in patients 2 years of age and older; we investigated its potential to prevent premature mortality and improve associated comorbidities. Experimental Approach The efficacy of sub-chronic cannabidiol administration in two mouse models which reproduce characteristics of Dravet syndrome was investigated. The effect of cannabidiol on neonatal welfare and survival was studied using Scn1a-/- mice. We then used a hybrid, heterozygote Scn1a+/- mouse model to study the effect of cannabidiol on survival and behavioural comorbidities; motor deficits (rotarod and static-beam test), gait abnormality (gait test), social anxiety (social interaction test), anxiety-like (elevated plus maze) and depressive-like behaviours (sucrose preference test) and cognitive impairment (radial arm maze test). Key Results In Scn1a-/- mice, cannabidiol increased survival and delayed worsening of neonatal welfare. In Scn1a+/- mice chronic cannabidiol administration did not show any adverse effect on motor function and gait, reduced premature mortality, improved social behaviour and memory function, and reduced anxiety-like and depressive-like behaviours. Conclusion and Implications We are the first to demonstrate a potential disease-modifying effect of cannabidiol in animal models of Dravet syndrome. cannabidiol treatment reduced premature mortality and improved several behavioural comorbidities in Dravet syndrome mice. These crucial findings may be translated into human therapy to address behavioural comorbidities associated with Dravet syndrome