Differential localization and characterization of functional calcitonin gene-related peptide receptors in human subcutaneous arteries

Calcitonin gene-related peptide (CGRP) and its receptor are widely distributed within the circulation and the mechanism behind its vasodilation not only differs from one animal species to another but is also dependent on the type and size of vessel. The present study examines the nature of CGRP-induced vasodilation, characteristics of the CGRP receptor antagonist telcagepant and localization of the key components calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1) of the CGRP receptor in human subcutaneous arteries

Cell therapy for ischemic stroke : are differences in preclinical and clinical study design responsible for the translational loss of efficacy?

Cell therapy is an attractive strategy for enhancing post‐stroke recovery. Different cell types and several treatment strategies have been successfully applied in animal models, but efficacy in stroke patients has not yet been confirmed. We hypothesize that the significant design differences between preclinical and clinical trials may account for this situation. Using a meta‐analysis approach and comparing preclinical with clinical trials, we reveal and discuss preliminary evidence for such design differences. While available datasets are not yet numerous enough to draw definitive conclusions, these findings may represent signposts on the route to efficacy by harmonizing preclinical and clinical study designs