Quasisynchronous LoRa for LEO nanosatellite communications

Perfect synchronization in LoRa communications between Low Earth Orbit (LEO) satellites and ground base stations is still challenging, despite the potential use of atomic clocks in LEO satellites, which offer high precision. Even by incorporating atomic clocks in LEO satellites, their inherent precision can be leveraged to enhance the overall synchronization process, perfect synchronization is infeasible due to a combination of factors such as signal propagation delay, Doppler effects, clock drift and atmospheric effects. These challenges require the development of advanced synchronization techniques and algorithms to mitigate their effects and ensure reliable communication from / to LEO satellites. However, maintaining acceptable levels of synchronization rather than striving for perfection, quasisynchronous (QS) communication can be adopted which maintains communication reliability, improves resource utilization, reduces power consumption, and ensures scalability as more devices join the communication. Overall, QS communication offers a practical, adaptive, and robust solution that enables LEO satellite communications to support the growing demands of IoT applications and global connectivity. In our investigation, we explore different chip waveforms such as rectangular and raised cosine. Furthermore, for the first time, we study the Symbol Error Rate (SER) performance of QS LoRa communication, for different spreading factors (SF), over Additive White Gaussian Noise (AWGN) channels.IEEE Communications Societ

Maternal and neonatal outcomes of pregnant women with SARS-CoV-2 infection in our tertiary hospital

Objective: To evaluate clinical features, laboratory test results, and maternal and neonatal outcomes of pregnant patients with the Coronavirus disease (COVID-19). Methods: We reviewed clinical data from pregnant women with a laboratory-confirmed SARS-CoV-2, who were admitted to our university hospital in Türkiye. Demographic and clinical characteristics, laboratory test results, and maternal and neonatal outcomes were collected. Results: A total of 46 pregnant women were included in this study. The mean maternal age was 28 (min. 21 – max. 39) years and gestational age was 31 (min. 26 – max. 41) weeks. Two (4.37%) pregnant women were vaccinated with 1 dose of BioNTech® vaccine, and all other patients were unvaccinated. Shortness of breath was the most common symptom present in 15 cases (32.6%). Twenty-seven (58.69%) pregnant women gave birth in the preterm period, and 19 (41.30%) in the term period. Six (13.04%) pregnant women were followed up in the Anesthesia Intensive Care Unit. Two women with critical COVID-19 died in the postpartum period. Conclusion: COVID-19 infection has negative consequences in terms of maternal and neonatal outcomes. The most common causes of adverse neonatal outcomes are iatrogenic or spontaneous preterm births, while the most common causes of adverse maternal outcomes are prolonged hospitalization time, increased likelihood of intensive care hospitalization, and maternal deaths. The most effective way to prevent this situation is to get vaccinated regardless of trimester

Anesthetic Management of a Pediatric Patient with Arginase Deficiency

Arginase deficiency is an autosomal recessive disorder of the urea cycle in which a defect in conversion of arginine to urea and ornithine leads to hyperammonemia. Patients with urea cycle disorders may show increased protein catabolism due to inadequate intake of energy, protein and essential amino acids; infections, fever and surgery. A 12-year-old girl with arginase deficiency, ASA II who weighed 40 kg was scheduled for bilateral adductor, quadriceps and gastrocnemius tenotomies. She had mental retardation, spasticity and flexion posture of thelower limbs. Metabolic homeostasis was restored with appropriate diet. Successful anesthetic management allowed the patient to be discharged 48 hours after surgery. Increased levels of arginine and ammonia during or after surgery may lead to serious complications such as hypotension, cerebral edema, convulsions, hypothermia and spasticity. Thus special attention must be given to metabolic homeostasis and nutrition of the patients with arginase deficiency in the perioperative period. Primary goals should be to minimize stress levels by effective anxiolysis, provide an adequate amount of protein-free energy with proper fluid management and to obtain an effective preemptive and postoperative analgesia. In addition to a high level of knowledge, successful anesthesia requires professional communication among nursing staff, dietitians, pediatric metabolism specialist, surgeon and anesthesiologist

Scientific publication performance of Turkish anaesthesia clinics in high impact factor international journals between 2005 and 2014 : a bibliometric analysis

Uluslararası yayın etkinliklerinin ölçülmesi bilim politikalarının doğru şekilde yürütülüp yürütülmediğinin somut göstergelerinden biridir. Türkiye`nin genel bilimsel etkinlik değerlendirmelerinde yayın sayısındaki hızlı artışa rağmen yayın kalitesinde aynı artışın görülmediği bildirilmiştir Özel olarak ülkemizdeki anestezi bilim dalının uluslararası yayın etkinlikleri henüz değerlendirilme- miştir. Çalışmamızda Türkiye`deki anestezi kliniklerinin son 10 yıl içerisindeki uluslararası yüksek kaliteli yayın üretkenliklerini değer- lendirerek güncel durumu ortaya koymayı amaçladık. Yöntemler: "Thomson Reuters InCities" ve Pubmed veri taban- larını kullanarak, son 10 yılda Türkiye`deki anestezistler tarafın- dan yapılan ve 2013 yılı etki değeri 1 ve üzerinde olan anestezi ve yoğun bakım konulu dergilerde yayınlanan çalışmaları listeledik. Her bir çalışmanın yayın yılını, konusunu, yöntemini, aldığı atıf sayısını ve hangi kurum tarafından yapıldığını kaydettik ve tanım- layıcı analizler yaptık Bulgular: Seçtiğimiz ölçütlere uyan toplam 630 yayın bulundu. Yayınların 525'i (%83) anestezi, 66'sı (%10) yoğun bakım, 39'u (%6) ağrı konuluydu. Yayınların ortalama atıf sayısı 9,90 idi. 376 kontrollü/randomize kontrollü klinik çalışma, 98 gözlemsel klinik çalışma, 66 laboratuvar çalışması, 64 vaka serisi/sunumu, 5 derleme ve 21 editöre mektup yayınlanmıştı. Yayınların %82,4'ü üniversite, %15,56'sı eğitim araştırma, %0,63'ü devlet/asker ve %1,27'i özel hastanelere aitti. En çok yayına sahip kurum Başkent Üniversitesi, en çok atıf alan kurum İstanbul Üniversitesi ve öğretim görevlisi başına en çok yayın üreten kurum Trakya Üniversitesi idi. Sonuç: Son 10 yıl içerisinde Türkiye'deki anestezi kliniklerinin yük- sek etki değerli uluslararası dergilerde yer alan yayın sayısı azalma eğilimindedir ve ortalama atıf sayısı dünya ortalamasının altındadırObjective: International scientific publication productivity is a tangible indicator for the accuracy of scientific policies. The quality of scientific publications is not increasing despite the fast increase in the publication count in Turkey. The international publication activities of Turkish anaesthesia clinics have not been previously explored. Thus, we aimed to evaluate the high quality scientific productivity of Turkish anesthesia clinics within the last 10 years. Methods: We searched for studies conducted by anaesthesiologists in Turkey within the last 10 years and published in journals listed under the medical subject categories of anaesthesiology and critical care using ‘Thomson Reuters InCites’ and PubMed databases. We recorded publication year, subject, method, citation count and origin of each paper and conducted descriptive analyses. Results: There were 630 papers meeting our inclusion criteria. Among those, 525 (83%) were studies on anaesthesia, 66 (10%) were studies on critical care and 39 (6%) were studies on pain. The average citation count was 9.90. There were 376 controlled/randomized controlled trials, 98 observational studies, 66 laboratory studies, 64 case series/reports, 5 reviews and 21 letters to the editor. Studies were conducted by universities (82.4%), by training and research hospitals (15.56%), by state and military hospitals (0.63%) and by physicians in private practice (1.27%). Baskent University had the highest publication count, Istanbul University had the highest citation count and Trakya University had the highest publication count per faculty teaching staff. Conclusion: The high-impact scientific productivity of Turkish anesthesia clinics is in a downward trend in the last 10 years, and the average citation count is lower than the global average

The activities of catalase, superoxide dismutase, adenosine deaminase, xanthine oxidase enzymes and levels of malondialdehyde and nitric oxide in lung tissue of rats exposed to subacute and subchronic formaldehyde

Amaç: Formaldehit (FA) irrite edici ve zehirli bir gazdır. Aldehit ailesinin en önemli üyesidir. FA anatomi, patoloji ve histoloji laboratuvarlarinda tahnit ve dezenfeksiyon işlemlerinde kullanılır. Bu çalışmada, subakut ve subkronik periyotlarda solunan FA'in akciğer dokusu enzim aktiviteleri ile MDA ve NO düzeylerine etkileri araştırılmıştır. Gereç ve yöntem: 60 adet erkek sıçan herbirinde 10 sıçan olmak üzere 6 gruba ayrıldı. Sıçanlar subakut (4 hafta) ve subkronik (13 hafta) olarak 0, 10 ve 20 ppm dozunda formaldehit gazına maruz bırakıldı Deneylerin sonunda sıçanlara eter anestezisi yapılarak dekapite edildi ve akciğer dokuları çıkarıldı. Homojenize edilerek biyokimyasal analizlerde kullanıldı. Bulgular: Akciğer dokusunda total SOD, CAT ADA, XO aktiviteleri ile MDA ve NO seviyeleri ölçüldü. Kontrol grubuna göre, subakut 10 ppm grubunda, SOD aktivitesinde anlamlı bir azalma saptandı. Subakut 20 ppm grubunda, CAT ve SOD aktivitelerinde belirgin bir azalma, MDA ve NOdüzeylerinde ise anlamlı bir artış vardı. Subkronik 10 ve 20 ppm gruplarında XO aktivitelerinde ve subkronik 20 ppm grubunda ise MDA ile NO seviyelerinde anlamlı artma tespit edildi. Sonuç: Sıçanların inhalasyon yoluyla formaldehite maruz bırakılması akciğerin enzimatik antioksidan sistemini olumsuz yönde etkilemektedir. MDA düzeylerinde ki artış, FA dozunun lipit peroksidasyonu üzerinde ve NO düzeylerindeki artış da, FA maruziyet süresinin oksidatif stres üzerinde etkili olduğunu düşündürmektedir.Purpose: Formaldehyde (FA) is an irritating and toxic gas. It is the most important member of aldehydes. FA is used in anatomy, pathology and histology laboratories, embalming and deselection procedures. The aim of this study is to investigate the effect of FA on the activities of the lung enzymes and MDA and NO levels in lung tissues exposed to subacute and subchronic FA inhalation. Methods: Sixty male rats were divided into six groups each included ten rats. The rats exposed to subacute (4 weeks) and subchronic (13 weeks) 0,10, 20 ppm FA. At the end of the exposure period, rats were decapitated under ether anesthesia. The lung tissues were extracted and homogenized and used in biochemical analyses. Results: The total activities of superoxide dismutase (SOD), catalase (CAT), adenosine deaminase (ADA), xanthine oxidase (XO) and levels of MDA, NO in lung tissue were measured. A significant decrease in SOD activity was found in subacute 10 ppm group compared to control group. There was a significant decrease in CAT and SOD activities in subacute 20 ppm group and significant increase in MDA and NO levels was found. We found significant XO activity increase at subchronic 10 and 20 ppm groups. Conclusion: We suggest that enzymatic antioxidant system of rat lungs were affected adversely from inhalation of FA. MDA levels suggests the importance of FA dosage on lipid peroxidation and NO levels suggests the importance of. FA exposure period on oxidative stress of lung tissue

The activities of catalase, superoxide dismutase, adenosine deaminase, xanthine oxidase enzymes and levels of malondialdehyde and nitric oxide in lung tissue of rats exposed to subacute and subchronic formaldehyde

Amaç: Formaldehit (FA) irrite edici ve zehirli bir gazdır. Aldehit ailesinin en önemli üyesidir. FA anatomi, patoloji ve histoloji laboratuvarlarinda tahnit ve dezenfeksiyon işlemlerinde kullanılır. Bu çalışmada, subakut ve subkronik periyotlarda solunan FA'in akciğer dokusu enzim aktiviteleri ile MDA ve NO düzeylerine etkileri araştırılmıştır. Gereç ve yöntem: 60 adet erkek sıçan herbirinde 10 sıçan olmak üzere 6 gruba ayrıldı. Sıçanlar subakut (4 hafta) ve subkronik (13 hafta) olarak 0, 10 ve 20 ppm dozunda formaldehit gazına maruz bırakıldı Deneylerin sonunda sıçanlara eter anestezisi yapılarak dekapite edildi ve akciğer dokuları çıkarıldı. Homojenize edilerek biyokimyasal analizlerde kullanıldı. Bulgular: Akciğer dokusunda total SOD, CAT ADA, XO aktiviteleri ile MDA ve NO seviyeleri ölçüldü. Kontrol grubuna göre, subakut 10 ppm grubunda, SOD aktivitesinde anlamlı bir azalma saptandı. Subakut 20 ppm grubunda, CAT ve SOD aktivitelerinde belirgin bir azalma, MDA ve NOdüzeylerinde ise anlamlı bir artış vardı. Subkronik 10 ve 20 ppm gruplarında XO aktivitelerinde ve subkronik 20 ppm grubunda ise MDA ile NO seviyelerinde anlamlı artma tespit edildi. Sonuç: Sıçanların inhalasyon yoluyla formaldehite maruz bırakılması akciğerin enzimatik antioksidan sistemini olumsuz yönde etkilemektedir. MDA düzeylerinde ki artış, FA dozunun lipit peroksidasyonu üzerinde ve NO düzeylerindeki artış da, FA maruziyet süresinin oksidatif stres üzerinde etkili olduğunu düşündürmektedir.Purpose: Formaldehyde (FA) is an irritating and toxic gas. It is the most important member of aldehydes. FA is used in anatomy, pathology and histology laboratories, embalming and deselection procedures. The aim of this study is to investigate the effect of FA on the activities of the lung enzymes and MDA and NO levels in lung tissues exposed to subacute and subchronic FA inhalation. Methods: Sixty male rats were divided into six groups each included ten rats. The rats exposed to subacute (4 weeks) and subchronic (13 weeks) 0,10, 20 ppm FA. At the end of the exposure period, rats were decapitated under ether anesthesia. The lung tissues were extracted and homogenized and used in biochemical analyses. Results: The total activities of superoxide dismutase (SOD), catalase (CAT), adenosine deaminase (ADA), xanthine oxidase (XO) and levels of MDA, NO in lung tissue were measured. A significant decrease in SOD activity was found in subacute 10 ppm group compared to control group. There was a significant decrease in CAT and SOD activities in subacute 20 ppm group and significant increase in MDA and NO levels was found. We found significant XO activity increase at subchronic 10 and 20 ppm groups. Conclusion: We suggest that enzymatic antioxidant system of rat lungs were affected adversely from inhalation of FA. MDA levels suggests the importance of FA dosage on lipid peroxidation and NO levels suggests the importance of. FA exposure period on oxidative stress of lung tissue

Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial

BACKGROUND & OBJECTIVES: Patients frequently experience pain of moderate to severe degree during gynaecologic procedures. This prospective, randomized, placebo-controlled trial was aimed to investigate the analgesic efficacy of preoperative oral dexketoprofen trometamol, intravenous paracetamol, lidocaine spray, pethidine and diclofenac sodium on fractional curettage procedure. METHODS: A total of 144 mutiparous women were randomly allocated to one of the six groups. The first group (control group) consisted of 22 participants and they did not receive any treatment. The second group had 26 participants receiving oral 25 mg dexketoprofen trometamol. The 23 participants of the third group received two puff lidocaine sprays on cervical mucosa. The forth group consisted of 25 participants receiving 100 mg pethidine. In the fifth group, the 23 participants received 1000 mg intravenous paracetamol and the sixth group consisted of 25 participants receiving diclofenac sodium. RESULTS: Pethidine was the best choice for reducing pain score during curettage procedure (t2:intra-operative). All analgesic procedures were significantly effective in reducing pain during postoperative period (t3). Significant pain reduction was achieved for both intra- and postoperative period by using analgesics. INTERPRETATION & CONCLUSIONS: The results of our study showed that lidocaine puffs provided the best pain relief than the other analgesics used. Therefore, lidocaine may be considered as the first choice analgesic in fractional curettage (NCT ID: 01993589)

The effects of inhaled formaldehyde on the activities of some metabolic enzymes in the liver of male rats: Subchronic (13-weeks) effects

We aimed to investigate the effects of different formaldehyde (FA) concentrations on some enzyme activities that take part in metabolic pathways in the liver. The enzymes studied were hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), lactate dehydrogenase (LDH), and malate dehydrogenase (MDH) which are included in the three main metabolic pathways; glycolysis, citric acid cycle, and pentose phosphate pathway. Thirty male Wistar albino rats were raudemly divided into 3 separate groups (10 per group). The first ten rats were used as control (grup I). Rats were exposed to atmosphere containing 10 and 20 ppm FA continuously (8 hours per day, 5 days per week) in groups II and III. HK, G6PD, 6PGD, LDH, and MDH activities were measured in liver tissues. The results showed a remarkable reduction in G6PD and 6PGD activities, significant increase in MDH activity in liver tissues from rats exposed to 10 ppm FA for 13-weeks. There were no differences in the activities of HK and LDH between test and control groups. Conversely G6PD activity was decreased and MDH activity was increased in liver tissues from rats exposed to 20 ppm FA for 13-weeks. These results may suggest the possible changing effect of FA inhalation on metabolic enzymes in liver