Current prevalence of self-reported interpersonal violence among adult patients seen at a university hospital emergency department in Switzerland.

To evaluate the current prevalence of self-reported interpersonal violence amongst patients consulting at the emergency department (ED) of a university hospital and to describe the characteristics of the violence sustained. Ours was a cross-sectional study using a modified version of the Partner Violence Screen questionnaire, which was distributed to every patient over 16 years old consulting at the ED between the 1st and 30th September 2016. Excluded were those incapable of decision-making, unable to understand owing to language difficulties, or in police detention. Questions pertained to violence endured during the year prior to their attendance at the ED and, where relevant, the date, place, and type of violence (physical or psychological), the perpetrator and the means used (firearms or other weapons). Demographic details were taken from the hospital records. Of 628 patients included (participation rate 86%), 19% were victims of violence, for 27% of whom it was the motive for ED attendance. The median age of these victims of violence was 28 years (interquartile range 22–43), 39% were female, 71% single and 38% foreign nationals. Typical characteristics of self-reported violence were: (1) violence sustained within the previous 24 h (26%); (2) perpetrators unknown (35%); (3) occurrence at a café, bar, restaurant or nightclub (32%); (4) use of knives (19%); (5) prior consumption of alcohol by the victims themselves (28%). Females were more susceptible to domestic violence than males (45 vs 7%), the latter mostly reporting public violence (64 vs 43% in women). The prevalence of self-reported interpersonal violence has reached one patient in five in our ED. Our results underline the importance of screening for this, as well as providing the means to offer specific follow-up. &nbsp

Infusional ECarboF in patients with advanced breast cancer: A very active and well-tolerated out-patient regimen

We performed a trial using the combination of epirubicin 50 mg/m2/day 1, carboplatinum AUC 5/day 1 and continuous 5-fluorouracil (5-FU) 200 mg/m2/day (every 4 weeks for 6 months) to confirm the efficacy and low toxicity profile of this regimen in breast cancer. In 51 patients with metastatic (n = 33) or locally advanced (n=18) breast cancer the overall response rate was 86% (95% confidence interval (95% CI): 73%-94%): 94% in locally advanced and 81% metastatic disease. Grade 3-4 toxicity was low: 4% of patients presented with febrile neutropenia, 16% with severe palmar-plantar syndrome, 10% with Port-a-cath thrombosis. This study confirms the high efficacy of infusional 5-FU-based regimens and justifies further research into novel promising oral 5-FU derivative

Low-dose intra-arterial contrast-enhanced MR aortography in patients based on a theoretically derived injection protocol

Multiple intra-arterial contrast agent injections are necessary during MR-guided endovascular interventions. In respect to the approved limits of maximum daily gadolinium dose, a low-dose injection protocol is mandatory. The objective of this study was to derive and apply a low-dose injection protocol for intra-arterial 3D contrast-enhanced MR aortography in patients. Injection rate (Qinj), concentration of injected gadolinium [Gd]inj and aortal blood flow rate (Qblood) were included for the theoretical evaluation of signal intensity (SI) of the arterial lumen. SI simulations were carried out at Qinj=2 versus 4ml/s in the [Gd]inj range between 0-500mM. Qinj and [Gd]inj with SI above the 75% threshold of the maximal SI were regarded as optimal injection parameters. [Gd]inj=50mM and Qinj=4ml/s were considered as optimal and were administered in five patients for 3D MR aortography. All images revealed clear delineation of the abdominal aorta and its major branches. Mean±SD of contrast-to-noise ratios of the abdominal aorta, common iliac and renal artery were 70.2±15.2, 58.6±12.3 and 67.4±12.3. Approximately seven intra-aortal injections would be permissible in patients during MR-guided interventions without exceeding the maximal dose of gadoliniu

Measurement of the asymmetries in 3He→ \overrightarrow{\sf He}(¯e, e′p)d and 3He→ \overrightarrow{\sf He}(¯e, e′p)np

Abstract.: The electron target asymmetries A || and A⊥ with target spin parallel and perpendicular to the momentum transfer \ensuremath{\boldsymbol{q}} were measured for both the two- and three-body breakup of 3He in the 3 $\overrightarrow{\rm He}$ (¯e, e'p)-reaction. Polarized electrons were scattered off polarized 3He in the quasielastic regime in parallel kinematics with the scattered electron and the knocked-out proton detected using the Three-Spectrometer Facility at MAMI. The results are compared to Faddeev calculations which take into account Final-State Interactions as well as Meson Exchange Currents. The experiment confirms the prediction of a large effect of Final-State Interactions in the asymmetry of the three-body breakup and of an almost negligible one for the two-body breaku

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

1 Adaptive visual attention model

which should be used for any reference to this wor