Periodontal microorganisms and diagnosis of malignancy : A cross-sectional study

BACKGROUND: Oral infections associate statistically with cancer. OBJECTIVE: We hypothesized that certain periodontal microorganisms might specifically link to malignancies in general and set out to investigate this in our ongoing cohort study. METHODS: A sample of 99 clinically examined patients from our cohort of 1676 subjects was used to statistically investigate the associations between harboring periodontal microorganisms Aggregatibacter actinomycetemcomitans (A.a), Porphyromonas gingivalis (P.g), Prevotella intermedia (P.i), Tannerella forsythia (T.f) and Treponema denticola (T.d). We used oral infection indexes and the incidence figures of malignancies as registered in 2008-2016 in the Swedish National Cancer Register. RESULTS: The pathogen A.a showed strong association with malignancy in 32 out of the 99 patients while P.g and P.i were more prevalent among patients without malignancy. In principal component analyses, A.a appeared in the strongest component while the second strongest component consisted of a combination of T.f and T.d. The third component consisted of a combination of P.g and P.i, respectively. Of basic and oral health variables, gingival index appeared to be the strongest expression of inflammation (Eigen value 4.11 and Explained Variance 68.44 percent). CONCLUSIONS: The results partly confirmed our hypothesis by showing that harboring certain periodontal bacteria might link to malignancy. However, the associations are statistical and no conclusions can be drawn about causality.Peer reviewe

Life satisfaction in patients with long-term non-malignant pain – relating LiSat-11 to the Multidimensional Pain Inventory (MPI)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Prevalence of cancer in relation to signs of periodontal inflammation

Funding Information: The study was supported by the Swedish Ministry of Health and Social Affairs (grant F84/ 189) and Karolinska Institutet, Stockholm, Sweden, and by grants from The Finnish Society of Sciences and Letters, the Finnish Medical Society, Finland, and the King Gustav V´s and Queen Victoria’ s Freemason´s Foundation, Sweden. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022 Meurman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.We investigated the associations between periodontal inflammation (gingivitis and periodontitis) and all-kind malignancies, specifically breast and prostate cancer, in a cohort followed-up for 30 years. The study hypothesis was based on the oral inflammation vs. systemic health paradigm. A sample of 2,168 subjects from an original cohort of 105,718 individuals from the greater Stockholm area in Sweden that had been followed since 1985 was investigated. Swedish national health registers were used in the study. Chi-square tests and logistic multiple regression analyses were conducted. The results showed that periodontitis was significantly associated with any cancer after adjusting for gender, age, income, and education (p = 0.015). The probability of getting cancer increased on average by 38% if the patient had periodontitis vs. had not; the odds ratio was 1.380 (95% confidence interval l.066-1.786). No significant association was observed between periodontitis and breast cancer (p = 0.608), while the association between periodontitis and prostate cancer tended towards significance (p = 0.082). However, no statistically significant difference was found between the observed and the calculated distribution of any cancer in gingivitis groups (p = 0.079). Thus, the study hypothesis was partly confirmed by showing a statistically significant association between periodontitis and any cancer.Peer reviewe

Novel Biochemical Markers of Psychosocial Stress in Women

Background: Prolonged psychosocial stress is a condition assessed through self-reports. Here we aimed to identify biochemical markers for screening and early intervention in women

Alna-utbildning ger mer alkoholprevention? - en jämförelse av alkoholpreventiva insatser rapporterade av utbildad och outbildad personal

Med syftet att förbättra det alkoholpreventiva arbetet på arbetsplatserna gav arbetsmarknadens parter genom ALNA en utbildning i alkoholförebyggande arbete på arbetsplatsen. Syftet med denna studie var att utvärdera denna utbildning. Designen var av icke-ekvivalent kontrollgruppstyp (kvasiexperimentell design) där grupperna visade sig vara lika i många relevanta avseenden. Förväntningarna var att den utbildade gruppen skulle göra fler alkoholpreventiva insatser på sina arbetsplatser än den ej utbildade gruppen. Vid uppföljning 12 månader efter utbildningen visades de utbildades arbetsplatser i högre grad ha en alkohol- och drogpolicy, en handlingsplan och en högre kunskap om vad man ska göra vid misstanke om missbruk.With the aim to improve the alcohol prevention in the workplace, the parts on the Swedish labour market through Alna started training in alcohol prevention on the workplace. This study is an evaluation of the training. The design was a non-equivalent control-group type where groups afterwards were found to be similar in many relevant respects. Expectations were that the trained group would make more alcohol preventive efforts at their workplaces than non-trained group. At follow-up 12 months after training, the workplaces of trained persons were shown to greater extent have an Alcohol and Drug policy, a plan of action and a greater knowledge of what to do in cases of suspected abuse

Effects of a school tobacco policy on student smoking and snus use

Objective: A school tobacco policy (STP) commonly is used to reduce smoking among adoles-cents, but the effectiveness of such programs is unclear. We evaluated the impact of an STP on tobacco use in 4 schools. Methods: The study included 4 intervention and 4 control schools, located in the inner city of Stockholm, Sweden. Schools self-selected for assignment to either an intervention program or a comparison group. In total, the study was comprised of 2671 students in grades 9 and 11, ages 15 to 18, and 1998 students (75%) responded to the questionnaire. We used a repeated cross-sectional design with assessment of tobacco use prevalence before im-plementation of the STP in 2016 and after 2 years under the program, in 2018. Results: Two years after the STP, the intervention school in grade 9 showed a lower prevalence (13.5% vs 1.6%) in the proportion of students who reported smoking (χ2 = 4.54; p < .05) whereas the proportion reporting snus use was practically unchanged. We found no statistically significant impact of the STP for grade 11. Conclusions: The results are promising with regard to smoking, when the STP is implemented in early adolescence

Att utvärdera och mäta tillsyn

Flera olika studier har utförts inom ramen för forskningsprojektet Utvärdering avtillsynen som styrmedel för att uppnå miljökvalitetsmålen (rapport 6912, 2019).Tre av studierna handlar om hur metoden Motiverande samtal kan användas i samband med inspektioner som rör avfallssortering och djurskydd. Den fjärde studien sammanställer forskarnas erfarenheter av att analysera tillsyn, med fokus på hur en tillsynsmyndighet kan mäta effekten av sina olika metoder