Limits or Integration? – Manufacturing Execution Systems and Operational Business Intelligence

Manufacturing Execution Systems (MES) and Operational Business Intelligence (OpBI) analyze and control operationalactivities in different organizational application fields. This raises the question how far these concepts are interrelated incontext of company-wide process coordination and analysis. The goal of this paper is the evaluation and conceptualclassification of MES and OpBI to base subsequent research actions. A literature review is conducted to recognize if arelationship of the concepts is taken into account in academics and to look for research gaps. Therefore, a representativenumber of articles have been extracted from selected scientific databases. The review results in four publications illuminatingonly single correlation aspects. This leads to the conclusion that further research in context of MES and OpBI is needed

IS THERE STILL A NEED FOR MULTIDIMENSIONAL DATA MODELS?

Organizational and technical changes challenge standards of data warehouse design and initiate a redesign of contemporary Business Intelligence and Analytics environments. As a result, the use of multidimensional models for performance oriented reasons is not necessarily taken for granted. Simple data models or operational structures emerge as a basis for complex analyses. The paper therefore conducts a laboratory experiment to examine from a non-technical perspective the influnce of different data modeling types on the representational information quality of end users. A comparison is made between the multidimensional model and the transactional model respectively the flat file model. The experiment involves 78 participants and aims to compare perceived and observed representational information quality aspects of ad hoc analyses regarding the data modeling type. The results indicate a higher observed quality for multidimensional modeled data, while different types of data models do not influnce the end user perception of the representational information quality

Applying Operational Business Intelligence in Production Environments

Operational Business Intelligence (OpBI) discusses a possible support of production-specific decisions by integrating and analyzing production data. The discussion of OpBI focusses thereby rather on common applicability aspects than on certain implementation strategies. This is however less conclusive for a functional reliability of OpBI in production environments and for associated efforts. Therefore, we introduce an OpBI framework to integrate and analyze data of production processes automatically. Following principles of design science research, framework evaluation refers to real-world data from a rod and wire rolling process. In conclusion, our OpBI framework improves information quality perceived by end users analyzing a steel’s rolling behavior

Flipped Classroom in der Wirtschaftsinformatik

Die Technische Universität Chemnitz und Technische Universität Bergakademie Freiberg führten im Rahmen des LiT-Projekts „FC WInf – Flipped Classroom in der Wirtschaftsinformatik“ ein kooperatives Lernprojekt im Sommersemester 2014 und Wintersemester 2014/2015 durch. Ziel war es, durch die Implementierung von Online-Lerneinheiten die individuelle Selbstlernphase der Studierenden zu stärken. Der Beitrag fasst die Konzeption und Durchführung zusammen und präsentiert wesentliche Ergebnisse der Evaluation

Ibrutinib combined with immunochemotherapy with or without autologous stem-cell transplantation versus immunochemotherapy and autologous stem-cell transplantation in previously untreated patients with mantle cell lymphoma (TRIANGLE):a three-arm, randomised, open-label, phase 3 superiority trial of the European Mantle Cell Lymphoma Network

Background: Adding ibrutinib to standard immunochemotherapy might improve outcomes and challenge autologous stem-cell transplantation (ASCT) in younger (aged 65 years or younger) mantle cell lymphoma patients. This trial aimed to investigate whether the addition of ibrutinib results in a superior clinical outcome compared with the pre-trial immunochemotherapy standard with ASCT or an ibrutinib-containing treatment without ASCT. We also investigated whether standard treatment with ASCT is superior to a treatment adding ibrutinib but without ASCT. Methods: The open-label, randomised, three-arm, parallel-group, superiority TRIANGLE trial was performed in 165 secondary or tertiary clinical centres in 13 European countries and Israel. Patients with previously untreated, stage II–IV mantle cell lymphoma, aged 18–65 years and suitable for ASCT were randomly assigned 1:1:1 to control group A or experimental groups A+I or I, stratified by study group and mantle cell lymphoma international prognostic index risk groups. Treatment in group A consisted of six alternating cycles of R-CHOP (intravenous rituximab 375 mg/m2 on day 0 or 1, intravenous cyclophosphamide 750 mg/m2 on day 1, intravenous doxorubicin 50 mg/m2 on day 1, intravenous vincristine 1·4 mg/m2 on day 1, and oral prednisone 100 mg on days 1–5) and R-DHAP (or R-DHAOx, intravenous rituximab 375 mg/m2 on day 0 or 1, intravenous or oral dexamethasone 40 mg on days 1–4, intravenous cytarabine 2 × 2 g/m2 for 3 h every 12 h on day 2, and intravenous cisplatin 100 mg/m2 over 24 h on day 1 or alternatively intravenous oxaliplatin 130 mg/m2 on day 1) followed by ASCT. In group A+I, ibrutinib (560 mg orally each day) was added on days 1–19 of R-CHOP cycles and as fixed-duration maintenance (560 mg orally each day for 2 years) after ASCT. In group I, ibrutinib was given the same way as in group A+I, but ASCT was omitted. Three pairwise one-sided log-rank tests for the primary outcome of failure-free survival were statistically monitored. The primary analysis was done by intention-to-treat. Adverse events were evaluated by treatment period among patients who started the respective treatment. This ongoing trial is registered with ClinicalTrials.gov, NCT02858258. Findings: Between July 29, 2016 and Dec 28, 2020, 870 patients (662 men, 208 women) were randomly assigned to group A (n=288), group A+I (n=292), and group I (n=290). After 31 months median follow-up, group A+I was superior to group A with 3-year failure-free survival of 88% (95% CI 84–92) versus 72% (67–79; hazard ratio 0·52 [one-sided 98·3% CI 0–0·86]; one-sided p=0·0008). Superiority of group A over group I was not shown with 3-year failure-free survival 72% (67–79) versus 86% (82–91; hazard ratio 1·77 [one-sided 98·3% CI 0–3·76]; one-sided p=0·9979). The comparison of group A+I versus group I is ongoing. There were no relevant differences in grade 3–5 adverse events during induction or ASCT between patients treated with R-CHOP/R-DHAP or ibrutinib combined with R-CHOP/R-DHAP. During maintenance or follow-up, substantially more grade 3–5 haematological adverse events and infections were reported after ASCT plus ibrutinib (group A+I; haematological: 114 [50%] of 231 patients; infections: 58 [25%] of 231; fatal infections: two [1%] of 231) compared with ibrutinib only (group I; haematological: 74 [28%] of 269; infections: 52 [19%] of 269; fatal infections: two [1%] of 269) or after ASCT (group A; haematological: 51 [21%] of 238; infections: 32 [13%] of 238; fatal infections: three [1%] of 238). Interpretation: Adding ibrutinib to first-line treatment resulted in superior efficacy in younger mantle cell lymphoma patients with increased toxicity when given after ASCT. Adding ibrutinib during induction and as maintenance should be part of first-line treatment of younger mantle cell lymphoma patients. Whether ASCT adds to an ibrutinib-containing regimen is not yet determined. Funding: Janssen and Leukemia &amp; Lymphoma Society.</p

Ibrutinib combined with immunochemotherapy with or without autologous stem-cell transplantation versus immunochemotherapy and autologous stem-cell transplantation in previously untreated patients with mantle cell lymphoma (TRIANGLE):a three-arm, randomised, open-label, phase 3 superiority trial of the European Mantle Cell Lymphoma Network

Background: Adding ibrutinib to standard immunochemotherapy might improve outcomes and challenge autologous stem-cell transplantation (ASCT) in younger (aged 65 years or younger) mantle cell lymphoma patients. This trial aimed to investigate whether the addition of ibrutinib results in a superior clinical outcome compared with the pre-trial immunochemotherapy standard with ASCT or an ibrutinib-containing treatment without ASCT. We also investigated whether standard treatment with ASCT is superior to a treatment adding ibrutinib but without ASCT. Methods: The open-label, randomised, three-arm, parallel-group, superiority TRIANGLE trial was performed in 165 secondary or tertiary clinical centres in 13 European countries and Israel. Patients with previously untreated, stage II–IV mantle cell lymphoma, aged 18–65 years and suitable for ASCT were randomly assigned 1:1:1 to control group A or experimental groups A+I or I, stratified by study group and mantle cell lymphoma international prognostic index risk groups. Treatment in group A consisted of six alternating cycles of R-CHOP (intravenous rituximab 375 mg/m2 on day 0 or 1, intravenous cyclophosphamide 750 mg/m2 on day 1, intravenous doxorubicin 50 mg/m2 on day 1, intravenous vincristine 1·4 mg/m2 on day 1, and oral prednisone 100 mg on days 1–5) and R-DHAP (or R-DHAOx, intravenous rituximab 375 mg/m2 on day 0 or 1, intravenous or oral dexamethasone 40 mg on days 1–4, intravenous cytarabine 2 × 2 g/m2 for 3 h every 12 h on day 2, and intravenous cisplatin 100 mg/m2 over 24 h on day 1 or alternatively intravenous oxaliplatin 130 mg/m2 on day 1) followed by ASCT. In group A+I, ibrutinib (560 mg orally each day) was added on days 1–19 of R-CHOP cycles and as fixed-duration maintenance (560 mg orally each day for 2 years) after ASCT. In group I, ibrutinib was given the same way as in group A+I, but ASCT was omitted. Three pairwise one-sided log-rank tests for the primary outcome of failure-free survival were statistically monitored. The primary analysis was done by intention-to-treat. Adverse events were evaluated by treatment period among patients who started the respective treatment. This ongoing trial is registered with ClinicalTrials.gov, NCT02858258. Findings: Between July 29, 2016 and Dec 28, 2020, 870 patients (662 men, 208 women) were randomly assigned to group A (n=288), group A+I (n=292), and group I (n=290). After 31 months median follow-up, group A+I was superior to group A with 3-year failure-free survival of 88% (95% CI 84–92) versus 72% (67–79; hazard ratio 0·52 [one-sided 98·3% CI 0–0·86]; one-sided p=0·0008). Superiority of group A over group I was not shown with 3-year failure-free survival 72% (67–79) versus 86% (82–91; hazard ratio 1·77 [one-sided 98·3% CI 0–3·76]; one-sided p=0·9979). The comparison of group A+I versus group I is ongoing. There were no relevant differences in grade 3–5 adverse events during induction or ASCT between patients treated with R-CHOP/R-DHAP or ibrutinib combined with R-CHOP/R-DHAP. During maintenance or follow-up, substantially more grade 3–5 haematological adverse events and infections were reported after ASCT plus ibrutinib (group A+I; haematological: 114 [50%] of 231 patients; infections: 58 [25%] of 231; fatal infections: two [1%] of 231) compared with ibrutinib only (group I; haematological: 74 [28%] of 269; infections: 52 [19%] of 269; fatal infections: two [1%] of 269) or after ASCT (group A; haematological: 51 [21%] of 238; infections: 32 [13%] of 238; fatal infections: three [1%] of 238). Interpretation: Adding ibrutinib to first-line treatment resulted in superior efficacy in younger mantle cell lymphoma patients with increased toxicity when given after ASCT. Adding ibrutinib during induction and as maintenance should be part of first-line treatment of younger mantle cell lymphoma patients. Whether ASCT adds to an ibrutinib-containing regimen is not yet determined. Funding: Janssen and Leukemia &amp; Lymphoma Society.</p

Linking Operational Business Intelligence with Value-Based Business Requirements

Part 3: Big and Open DataInternational audienceOperational business intelligence (OpBI) integrates data of business processes to analyse their performance in relation to organizational goals. The consequent decision-making concerns a timely recognition and execution of actions to maintain performant business processes. OpBI systems can be designed according to a firm-specific definition of requirements guided by considerations from business model, business process and information system perspective. However, there is no approach to link the design of OpBI jointly with characteristics of business models and business processes, yet. The paper uses therefore an action research method and proposes a business approach that combines e3value with the work system framework to set up conceptual application designs for an OpBI-reliant decision support. We report on results of a long-term research project to demonstrate the development and application of our approach in four different business scenarios. The findings include implications towards a business-oriented application design of OpBI systems

Operational Business Intelligence Meets Manufacturing

Industrial organizations design manufacturing processes to compete in dynamic environments so that their products incorporate a maximum value for the customers. This enforces the analysis and control of the corresponding product feature creation and implicates a coincidence of logistical and engineering processes. However, the existing information systems in manufacturing do not provide adequate decision making capabilities for a determination of a specific product feature’s value. The paper explores therefore certain advantages of Operational Business Intelligence (OpBI) in this context to give practical insights by a case study oriented approach. The results demonstrate requirements for a decision support in order to analyze and control manufacturing processes of three different industrial organizations. The insights confirm the benefits and advantagenous of OpBI in manufacturing