The drivers of private and public eco-innovations in six large countries

The purpose of this paper is to examine and compare the contributions to environmental innovation of the public sector and private sector, respectively, and to compare their determinants. We analyze the development over time of triadic patents, classified as environmental technological innovations, for six major patenting countries from 1990 to 2014. This is done using a factor decomposition analysis framework. The analysis is done at both country aggregate level, and for a set of specific technological topics: alternative energy production, energy conservation, agriculture and forestry, and waste management. Results indicate that there has been a shift at an aggregate level towards environmentally sustainable technologies. In the private sector, the shift can be attributed to changes in research priorities and an increased scale of R&D. In the public sector, increased patenting of environmentally sound technologies can be attributed to efficiency gains. The largest difference between the public and private sector is observed in R&D efficiency, where in the private sector, reductions in efficiency have contributed negatively to patent growth, whereas the opposite is true for the public sector. In both sectors, research focus has shifted towards energy-related technologies

Changes in muscle strength, muscle fibre size and myofibrillar gene expression after immobilization and retraining in humans

Changes in muscle strength, vastus lateralis fibre characteristics and myosin heavy-chain (MyoHC) gene expression were examined in 48 men and women following 3 weeks of knee immobilization and after 12 weeks of retraining with 1866 eccentric, concentric or mixed contractions.Immobilization reduced eccentric, concentric and isometric strength by 47 %. After 2 weeks of spontaneous recovery there still was an average strength deficit of 11 %. With eccentric and mixed compared with concentric retraining the rate of strength recovery was faster and the eccentric and isometric strength gains greater.Immobilization reduced type I, IIa and IIx muscle fibre areas by 13, 10 and 10 %, respectively and after 2 weeks of spontaneous recovery from immobilization these fibres were 5 % smaller than at baseline. Hypertrophy of type I, IIa and IIx fibres relative to baseline was 10, 16 and 16 % after eccentric and 11, 9 and 10 % after mixed training (all P < 0.05), exceeding the 4, 5 and 5 % gains after concentric training. Type IIa and IIx fibre enlargements were greatest after eccentric training.Total RNA/wet muscle weight and type I, IIa and IIx MyoHC mRNA levels did not change differently after immobilization and retraining. Immobilization downregulated the expression of type I MyoHC mRNA to 0.72-fold of baseline and exercise training upregulated it to 0.95 of baseline. No changes occurred in type IIa MyoHC mRNA. Immobilization and exercise training upregulated type IIx MyoHC mRNA 2.9-fold and 1.2-fold, respectively. For the immobilization segment, type I, IIa and IIx fibre area and type I, IIa and IIx MyoHC mRNA correlated (r = 0.66, r = 0.07 and r = −0.71, respectively).The present data underscore the role muscle lengthening plays in human neuromuscular function and adaptation

Developing New Methods to Answer Old and New Questions in Neurodegenerative Diseases

The HUPO Brain Proteome Project (HUPO BPP) held its 21(st) workshop in Honolulu, Hawaii. During the 23-24 January 2014 the island became the center of the open workshop of the scientific community