453 research outputs found

    Integrability of a conducting elastic rod in a magnetic field

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    We consider the equilibrium equations for a conducting elastic rod placed in a uniform magnetic field, motivated by the problem of electrodynamic space tethers. When expressed in body coordinates the equations are found to sit in a hierarchy of non-canonical Hamiltonian systems involving an increasing number of vector fields. These systems, which include the classical Euler and Kirchhoff rods, are shown to be completely integrable in the case of a transversely isotropic rod; they are in fact generated by a Lax pair. For the magnetic rod this gives a physical interpretation to a previously proposed abstract nine-dimensional integrable system. We use the conserved quantities to reduce the equations to a four-dimensional canonical Hamiltonian system, allowing the geometry of the phase space to be investigated through Poincar\'e sections. In the special case where the force in the rod is aligned with the magnetic field the system turns out to be superintegrable, meaning that the phase space breaks down completely into periodic orbits, corresponding to straight twisted rods.Comment: 19 pages, 1 figur

    Design optimization of multibody systems by sequential approximation

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    Abstract. Design optimization of multibody systems is usually established by a direct coupling of multibody system analysis and mathematical programming algorithms. However, a direct coupling is hindered by the transient and computationally complex behavior of many multibody systems. In structural optimization often approximation concepts are used instead to interface numerical analysis and optimization. This paper shows that such an approach is valuable for the optimization of multibody systems as well. A design optimization tool has been developed for multibody systems that generates a sequence of approximate optimization problems. The approach is illustrated by three examples: an impact absorber, a slider-crank mechanism, and a stress-constrained four-bar mechanism. Furthermore, the consequences for an accurate and efficient accompanying design sensitivity analysis are discussed

    ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients

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    Amyloid β is an in vitro substrate for P-glycoprotein (P-gp), an efflux pump at the blood brain barrier (BBB). The Multi Drug Resistance (ABCB1) gene, encoding for P-gp, is highly polymorphic and this may result in a changed function of P-gp and may possibly interfere with the pathogenesis of Alzheimer's disease. This study investigates to what extent ABCB1 Single Nucleotide Polymorphisms (SNPs; C1236T in exon 12, G2677T/A in exon 21 and C3435T in exon 26) and inferred haplotypes exist in an elderly population and if these SNPs and haplotypes differ between patients with dementia and age-matched non-demented control patients. ABCB1 genotype, allele and haplotype frequencies were neither significantly different between patients with dementia and age-matched controls, nor between subgroups of different types of dementia nor age-matched controls. This study shows ABCB1 genotype frequencies to be comparable with described younger populations. To our knowledge this is the first study on ABCB1 genotypes in dementia. ABCB1 genotypes are presently not useful as a biomarker for dementia, as they were not significantly different between demented patients and age-matched control subjects

    Carbon monoxide (CO) cycling in the Fram Strait, Arctic Ocean

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    Carbon monoxide (CO) influences the radiative budget and oxidative capacity of the atmosphere over the Arctic Ocean, which is a source of atmospheric CO. Yet, oceanic CO cycling is understudied in this area, particularly in light of the ongoing rapid environmental changes. We present results from incubation experiments conducted in the Fram Strait in August–September 2019 under different environmental conditions: while lower pH did not affect CO production (GPCO) or consumption (kCO) rates, enhanced GPCO and kCO were positively correlated with coloured dissolved organic matter (CDOM) and dissolved nitrate concentrations, respectively, suggesting microbial CO uptake under oligotrophic conditions to be a driving factor for variability in CO surface concentrations. Both production and consumption of CO will likely increase in the future, but it is unknown which process will dominate. Our results will help to improve models predicting future CO concentrations and emissions and their effects on the radiative budget and the oxidative capacity of the Arctic atmosphere.</p

    Trajectories of long-term exposure to anticholinergic and sedative drugs: A latent class growth analysis

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    Introduction: A variety of drugs, which are frequently prescribed to older people, have anticholinergic and sedative effects whereby they may impair cognitive and physical function. Although substantial inter-individual variation in anticholinergic and sedative exposure has been documented, little is known about subpopulations with distinct trajectories of exposure. Methods: Data from the Longitudinal Aging Study Amsterdam (LASA), an ongoing Dutch population-based cohort study, collected over 20 years (1992-2012) at seven occasions, were analyzed. On each occasion, cumulative anticholinergic and sedative exposure was quantified with the Drug Burden Index, a linear additive pharmacological dose-response model. The most likely number of trajectories were empirically derived with Latent Class Growth Analysis using "Goodness of fit" statistics. Trajectories were then compared on physical and cognitive function. Results: A total of 763 participants completed all follow-ups (61% women; mean age 83, ±6). "Goodness of fit" statistics (Bayesian In-formation Criterion = 22916, Bootstrapped Likelihood Ratio Test of 3 vs. 2 classes = 514.12

    Polyvinylpyrrolidone-Coordinated Single-Site Platinum Catalyst Exhibits High Activity for Hydrogen Evolution Reaction

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    The essence of developing a Pt‐based single‐atom catalyst (SAC) for hydrogen evolution reaction (HER) is the preparation of well‐defined and stable single Pt sites with desired electrocatalytic efficacy. Herein, we report a facile approach to generate uniformly dispersed Pt sites with outstanding HER performance via a photochemical reduction method using polyvinylpyrrolidone (PVP) molecules as the key additive to significantly simplify the synthesis and enhance the catalytic performance. The as‐prepared catalyst displays remarkable kinetic activities (20 times higher current density than the commercially available Pt/C) with excellent stability (76.3 % of its initial activity after 5000 cycles) for HER. EXAFS measurements and DFT calculations demonstrate a synergetic effect, where the PVP ligands and the support together modulate the electronic structure of the Pt atoms, which optimize the hydrogen adsorption energy, resulting in a considerably improved HER activity
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