Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy

S.G.D. is a recipient of an Oxford UCB Prize Fellowship in Biomedical Research and also received funding from Arthritis Research UK (grant no: 20506). Arthritis Research UK also supported UO (program grant 20522). J.D. received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant no: 677542) and the Barts Charity (grant no: MGU0343). J.D. is also supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (grant 107613/Z/15/Z). Research at NDORMS, University of Oxford is supported through the National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Centre (BRC)

Electrocardiographic characteristics of focal atrial tachycardias

Focal atrial tachycardia (AT) is uncommon and characterized by centrifugal atrial activation from a point source. ATs are found clustering around well-defined sites of structural and electrophysiologic heterogeneity in both atria. Focal AT most often occurs in patients without structural heart disease. The P-wave morphology on the surface ECG provides a good guide to the site of origin. With electrophysiologic study, activation mapping efforts can begin in the region suggested by P-wave analysis. Catheter ablation is an effective therapy that can result in long-term cure in most patients with a low risk of complications