Synthesis of new chiral organosulfur donors with hydrogen bonding functionality and their first charge transfer salts

The syntheses of a range of enantiopure organosulfur donors with hydrogen bonding groups are described including TTF related materials with two, four, six and eight hydroxyl groups and multiple stereogenic centres and a pair of chiral N-substituted BEDT-TTF acetamides. Three charge transfer salts of enantiopure poly-hydroxy-substituted donors are reported, including a 4:1 salt with the meso stereoisomer of the dinuclear [Fe2(oxalate)5 ]4- anion in which both cation and anion have chiral components linked together by hydrogen bonding, and a semiconducting salt with triiodide

Enantiopure and racemic radical-cation salts of bis(2’-hydroxylpropylthio)(ethylenedithio)TTF with polyiodide anions

The chiral TTF-based donor molecule bis(2’-hydroxylpropylthio)(ethylenedithio)tetrathiafulvalene (BHPT-EDT-TTF) has produced enantiopure R,R and S,S radical-cation salts with polyiodide anions I3- and I82-. Enantiomorphic 6:6 donor:I3 phases grown from either the R,R or S,S donor are semiconducting with similar activation energies of 0.24-0.30 eV and 0.22-0.23 eV respectively, and contains three unique face-to-face donor pairs whose relative orientation is determined by side chain conformations and hydrogen bonding. Racemic material under the same conditions gave an insulating centrosymmetric phase with R,R and S,S donor cations in a face-to-face pair partnered with an octa-iodide dianion, and with a ca 3:1 disorder between the enantiomers. Enantiopure BHPT-EDT-TTF yielded two further insulating crystalline phases of composition 2:2 with triiodide and 2:1 with octa-iodide

Molecular Mechanisms Leading from Periodontal Disease to Cancer

Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKL–RANK signaling axis as well as circulating cytokines/leukocytes and carcinogenesis. Due to the nonconclusive data associating periodontitis and cancer reported in the case and cohort studies, we examine clinical trials relevant to the topic and summarize their outcome

Motility-based label-free detection of parasites in bodily fluids using holographic speckle analysis and deep learning

Imaging: Detecting parasites with holograms and AI Scientists have developed a cost-effective and portable technology that uses three-dimensional holograms to detect parasites in human bodily fluids, providing a more sensitive technique for diagnosing diseases, without the need for chemical labeling. A major global health problem, parasitic infections affect billions of people around the world and can lead to severe illnesses and death. Some of the current screening techniques, however, use manual microscopic examinations that struggle to provide the sensitivity required for early diagnoses. Now, Aydogan Ozcan and colleagues from the University of California Los Angeles in the United States have developed a cost-effective and portable optical device that uses lensless time-resolved holographic speckle imaging combined with artificial intelligence to automatically detect rare parasites in bodily fluids. The device has the potential to perform rapid and early diagnoses of diseases caused by parasitic infections and could be used in developing countries