Adjuvant Radiotherapy Approach in Stage I High Risk and High-intermediate Risk Endometrioid-type Uterine Cancers TROD 04-005 Gynecological Tumors Subgroup Survey Study

OBJECTIVE Evaluation of adjuvant therapy approach in Stage I, high and high-intermediate risk endometrioid-type uterine cancers with a survey. METHODS Our survey, which was designed as the Turkish Society of Radiation Oncology-Gynecological Tumors Subgroup Study asked adjuvant therapy preference (ATP) according to different scenarios. RESULTS A total of 122 people participated in the survey. Myometrial invasion and grade were chosen the most frequently evaluated prognostic factor. In patients with Stage 1A-B, Grade 1-2, lymphovascular invasion (LVI) (+) as determined by the staging surgery (SS), the ATP was 68% for vaginal brachytherapy (VB). In 48 (40%) participants who did not recommend SS for the patient without SS, the recommendations were external radiotherapy (ERT)+VB in 33%. In Stage 1A, Grade 3, LVI (-) patients who had undergone SS, the ATP was 63% for VB. For LVI (+) patients in the same group, the ATP was 43% for ERT+VB. In 39 (32.5%) participants who did not recommend SS for the patient without SS, the recommendations were ERT+VB in 43%. In Stage 1B, Grade 3, LVI (-) patients who had undergone SS, ATP was 45% for ERT+VB. For the LVI (+) positive patients, the ATP was 71% for ERT+VB. In 31 (26%) participants who did not recommend SS, for the patient without SS, the recommendations were ERT+VB in 55%. CONCLUSION Our survey showed that ATP of participants was similar to current guidelines. They preferred adjuvant therapy as a multi-modality treatment instead of single-modality in the presence of prognostic factors, such as not performing SS or LVI

Outcomes of Surgery and Craniospinal Radiotherapy for Adult Patients with Medulloblastoma

OBJECTIV

Evaluation of the Treatment Field Deviations in Different Set-up Positions During Thoracic Radiotherapy in Lung Cancer Patients

OBJECTIVE The purpose of the study was to evaluate the treatment field deviations in lung cancer patients treated with thoracic radiotherapy (RT) performed using different immobilization devices into three different set-up positions and the influencing factors. METHODS Thirty lung cancer patients having palliative thoracic RT indication were randomized into three different set-up positions using different immobilization devices (Group I: arm along the body, Group II: lung board, and Group III: arm supported board). The treatment field center deviation was measured on sternal (X and Y axis) and axillary (z and theta axis) cross. In addition, parameters such as age, pain, pulmonary function test, set-up time, the temperature difference between the treatment room and the outside environment, and patient education level that may cause set-up were evaluated. RESULTS Mean intra-fraction field center deviations of 5.66 +/- 4.15 mm were observed in the right (z) axis (p=0.049) and 5.53 +/- 4.81 mm in the left (z) axis (p=0.015) in Group II which were statistically significantly larger than the deviations in other groups. A statistically significant correlation was found between the indoor and outdoor temperature difference and set-up time. CONCLUSION Both set-up positions of Groups I and III, gave better results than the position of Group II. According to our results, if a lung board will be used, adding the arm supporting accessory will be necessary. Random errors can be minimized and the set-up quality improved by using appropriate immobilization devices, minimizing the total set-up time and balancing the in and outdoor temperature by air conditioning system

Treatment results in patients with ductal carcinoma in situ treated with adjuvant radiotherapy

Background/aim: The aim of this study was to evaluate the treatment results of patients undergoing adjuvant radiotherapy (ART) after breast surgery with the diagnosis of ductal carcinoma in situ (DCIS)

The Effect of Dose-Volume Parameters on Central Nervous System Relapse in Pediatric Patients with Acute Leukemia Receiving Prophylactic Cranial Irradiation.

AIM OF THE STUDY: To investigate the effects of dosevolume parameters of brain parenchyma, optic nerves (ONs) and cribriform plate (CP), which were determined on central nervous system (CNS) control in pediatric leukemia patients who have undergone prophylactic cranial irradiation (PCI) at our department. PATIENTS AND METHODS: In the current study, the records of 14 patients were examined retrospectively. Along with the minimum and maximum doses for brain and CP, D95% (minimal dose received by the 95% volume of a structure) and V95% (percent volume of target receiving 95% of prescribed dose) could be obtained from the dose-volume histogram. Statistical analyses were conducted using the Mann Whitney test in SPSS-15. RESULTS: ALL/AML ratio was 9/5. CNS relapse was observed only in 2 patients. The minimum dose was 1249 (1100-1782) cGy, 1036 (547-1651) cGy, 856 (308-1460) cGy and 1234 (922-1727) cGy for brain parenchyma, right ON, left ON and CP, respectively. The value of D95%/D was 1.01 (1-1.06) and 0.99 (0.92- 1.06) for brain parenchyma and CP, respectively. V95% was 99.8 % (98.6%-100%) and 98.1% (80.5%-100%) for brain parenchyma and CP, respectively. The analyses revealed that none of the target tissue dose-volume parameters for PCI affected CNS relapse (p>0.05). CONCLUSION: In our study; it was found that the dosevolume parameters of the brain, CP and ONs did not have any effect on CNS relapse. Along with the other clinical factors, the scarce number of patients included in the study might have concealed the effects of parameters related to RT

Oncological outcomes for encapsulated papillary carcinoma of the breast: Multicentric study of Turkish Society for Radiation Oncology breast cancer study group (TROD 06-014 study)

BackgroundEncapsulated papillary carcinoma (EPC) is a rare malignant papillary breast cancer accounting for approximately .5%-2% of all breast tumors. The aim of this multicenter study was to evaluate clinicopathologic features of EPC in addition to oncological outcomes and radiotherapy (RT) details. MethodsFrom 10 different academic hospitals in Turkey, we obtained pathology reports of 80 patients with histologically confirmed EPC between 2005 and 2022. Demographic, diagnostic, and treatment data were collected from medical records, retrospectively. Local failure, distant progression, toxicity-adverse effects, overall survival (OS), and disease-free survival were evaluated, and survival analyzes were performed using the Kaplan-Meier method. ResultsEighty patients with the diagnosis of misspelled sorry (ECP) were retrospectively evaluated. The median age of the patients was 63 (range, 35-85). After a median follow-up of 48 (range; 6-206) months, local recurrence was observed in three patients (4%). Local recurrence was less common in the patients who received whole breast RT with a tumour bed boost (p = .025). There were not any distant metastasis or disease-related death. RT was applied to 61% of the cases, and no treatment-related grade 3 or higher toxicity was reported in any of the patients. Five year OS, cancer-specific survival (CSS), and were observed as 85%, 100%, and 96%, respectively. ConclusionsECP is a rare, slow-progressing breast carcinoma associated with good prognosis, it is a disease of elderly patient, and usually occurs in postmenopausal women. It responds extremely well to optimal local treatments and appropriate adjuvant treatments on a patient basis, and has excellent OS and CSS ratios