Evaluation of the Engineering Company΄s Performance

Import 05/08/2014Cílem této diplomové práce je analyzovat a zhodnotit výkonnost podniku LUCCO a.s. pomocí vybraných metod a na základě zjištěných výsledků navrhnout doporučení pro případné zlepšení.V teoretické části jsou popsány pojmy výkonnost a jednotlivé metody tj. SWOT analýza, BSC, a bonitní a bankrotní modely, které se aplikují v praktické části. V praktické části diplomové práce se nachází charakteristika podniku LUCCO a.s. a následně zde budou zpracovány a popsány jednotlivé metody a okomentována výsledná zjištění. V poslední části jsou doporučení pro zlepšení výkonnosti podniku.The aim of this thesis is to analyze and evaluate the performance of the company as LUCCO using selected methods and based on the findings propose recommendations for possible zlepšení.V theoretical part describes the concepts and the performance of each method, ie, SWOT analysis, BSC, and value and bankruptcy models that are applied in the practical part. In the practical part of the thesis is characteristic of the enterprise as LUCCO and then there will be processed and described various methods and discussed the resulting findings. In the last section are recommendations for improving business performance.152 - Katedra podnikohospodářskávelmi dobř

Exposure protocol of CS and HDM or PBS (adapted from [4]).

<p>The shaded region represents CS or air exposure.</p

Effect of CD44 on lymph node cytokine production upon combined HDM/CS exposure and HDM restimulation.

<p><b>A-E:</b> Cytokine levels in supernatant of mediastinal lymph node cell cultures from WT and CD44 KO mice that were exposed for 3 weeks to PBS/air, PBS/CS, HDM/air or HDM/CS, upon restimulation with HDM. <b>A-C</b>: Th2 cytokines (IL-4, IL-5 and IL-13). <b>D:</b> Th1 cytokine (IFN-γ). <b>E:</b> Th17 cytokine (IL-17). *p<0.05, **p<0.01, ***p<0.005; n = 8–10 mice/group.</p

Effect of CD44 on airway wall eosinophilia upon combined HDM/CS exposure.

<p>Quantification of eosinophils in airway wall in WT and CD44 KO mice (<b>A</b>). Congo Red staining was used to identify eosinophils in bronchial wall (<b>B</b>). *p<0.05, **p<0.01, ***p<0.005; n = 8–10 mice/group.</p

Effect of CD44 on goblet cell formation upon combined HDM/CS exposure.

<p>Quantification of mucus producing cells in WT and CD44 KO mice (<b>A</b>). Periodic acid-Schiff (PAS) stain was used to identify goblet cells in the airway mucosa (<b>B-F</b>).ⱡ: Figure representative of PBS/Air and PBS/CS of WT and CD44 KO mice. *p<0.05, **p<0.01, ***p<0.005; n = 8–10 mice/group.</p

Effect of CD44 on hyaluronic acid and osteopontin levels upon combined HSM/CS exposure.

<p>HA (A) and OPN (B) levels in BALF of WT and CD44 KO mice that were exposed for 3 weeks to PBS/air, PBS/CS, HDM/air or HDM/CS. *p<0.05, **p<0.01, ***p<0.005; n = 8–10 mice/group.</p

Additional file 1: Figure S1. of Determinants and impact of suboptimal asthma control in Europe: The INTERNATIONAL CROSS-SECTIONAL AND LONGITUDINAL ASSESSMENT ON ASTHMA CONTROL (LIAISON) study

Scatter plot of ACQ and miniAQLQ scores. Table S1. Characteristics of asthma. Table S2. Lung function. Table S3. Propensity to adhere to therapy. Table S4. Healthcare resources consumption. Table S5. Healthcare and economic resources consumption by country. (DOCX 155 kb

Additional file 1: of Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma

Baseline characteristics for the AZISAST-trial (XLS 26 kb

Effect of CD44 on proinflammatory mediator production upon combined HDM/CS exposure.

<p>Proinflammatory mediator levels in lungs of WT and CD44 KO mice. IL-1β (A) and IL-33 (B) protein levels and CXCL1 (C) and CCL11 (D) mRNA expressions. *p<0.05, **p<0.01, ***p<0.005; n = 10 mice/group.</p

Additional file 1: of End-stage cystic fibrosis lung disease is characterised by a diverse inflammatory pattern: an immunohistochemical analysis

Table S1. Detailed overview of the used primary and secondary antibodies, and chromogens. Superscript numbers (1–5) above the catalogue number indicate which primary antibody is combined with which secondary antibody and chromogen. Abbreviation: RTU = ready to use. Table S2. Inter- and intra-observer variability in the counting of the myeloid and lymphoid cells, expressed by means of the Spearman’s rank correlation coefficient. Significant correlations are indicated with *, with *** = p < 0.001. Table S3. Overview of the number of analysed follicles in each compartment for every included tissue block. CF11-20 represents the female CF patients. Table S4. Quantification of the myeloid cell types and lymphoid follicles according to localization (subdivided in the three compartments: airways, parenchyma and perivascular). The p-values in the right-hand column are the result of Kruskal-Wallis 1-way ANOVA testing. Significant differences with airways are indicated with *, with * = p < 0.05, ** = p < 0.01 and *** = p < 0.001. These values are the results of Dunn’s post hoc testing. Figure S1. Histological section of formalin-fixed paraffin-embedded CF lung tissue. Section was stained for mast cells (tryptase). Representative image showing an airway surrounded by circular fibrosis suggestive of constrictive bronchiolitis. The bronchiole is accompanied by its blood vessel. Abbreviations: AW = airway, BV = blood vessel. Scale bar = 100 μm. Figure S2. Serial histological sections of formalin-fixed paraffin-embedded CF lung tissue. Both images show the same lymphoid follicles located in the proximity of an airway. Panel A shows a CD20 staining of all B cells lying organised in germinal centres. These are surrounded by a paracortex staining positively for CD3 T cells (panel B). High endothelial venules (green arrowhead) allowing extravasation of naïve B and T cells into the lymphoid follicle are located in the T cell area. AW = airway. Scale bar = 50 μm. (DOCX 19517 kb