Making the economic case for adult social care: the EconomicS of Social carE CompEndium (ESSENCE) project

Constrained social care resources mean that decision-makers must make difficult choices about how to allocate them to best effect. The EconomicS of Social carE CompEndium (ESSENCE) project aims to collate and build economic evidence on adult social care (including both cost and outcome data) and make it available to decision-makers, managers, practitioners and individuals who use or pay for services themselves. Searches for economic evidence were undertaken across a range of databases. The ESSENCE toolkit offers a comprehensive collection of relevant research and summarises it with individual case summaries and a searchable database. Seventeen case summaries and a database with 231 sources have been produced to date, published on the project website. Evidence is grouped into service categories, focussing primarily on interventions considered core to adult social care for which there are studies considered to be robust in terms of design, quality, consistency and setting. The toolkit also provides signposts to interventions where it is currently not possible to examine the economic case but which could be evaluated in future research

Des conflits de lois en matière de délit et de quasi-délit en droit international privé québécois

"La rapidité des moyens de communication et le développement considérable du transport aérien, maritime et terrestre, permettent à l'homme moderne de se déplacer avec une grande facilité. Le problème du transport n'existe plus, et chaque jour des milliers d'individus quittent leur pays pour séjourner à l'étranger. Ce va-et-vient international croissant n'a pas été sans occasionner un bon nombre de conflits juridiques, plus particulièrement dans le domaine qui nous intéresse ici, celui des délits et des quasi-délits. [...]

Human Parainfluenza Type 4 Infections, Canada

During the fall/winter season of 2004–05, we found 9 respiratory specimens positive for human parainfluenza virus type 4 (HPIV-4) in our laboratory (43% of all HPIVs) from patients with mild to moderate respiratory illnesses. Sequencing studies identified 8 different HPIV-4A strains and 1 HPIV-4B strain

Graphene Bioelectronic Nose for the Detection of Odorants with Human Olfactory Receptor 2AG1

A real-time sensor for the detection of amyl butyrate (AB) utilising human olfactory receptor 2AG1 (OR2AG1), a G-protein coupled receptor (GPCR) consisting of seven transmembrane domains, immobilized onto a graphene resistor is demonstrated. Using CVD graphene as the sensor platform, allows greater potential for more sensitive detection than similar sensors based on carbon nanotubes, gold or graphene oxide platforms. A specific graphene resistor sensor was fabricated and modified via non-covalent π–π stacking of 1,5 diaminonaphthalene (DAN) onto the graphene channel, and subsequent anchoring of the OR2AG1 receptor to the DAN molecule using glutaraldehyde coupling. Binding between the target odorant, amyl butyrate, and the OR2AG1 receptor protein generated a change in resistance of the graphene resistor sensor. The functionalized graphene resistor sensors exhibited a linear sensor response between 0.1–500 pM and high selectively towards amyl butyrate, with a sensitivity as low as 500 fM, whilst control measurements using non-specific esters, produced a negligible sensor response. The approach described here provides an alternative sensing platform that can be used in bioelectronic nose applications