56 research outputs found

    Advancing epilepsy genetics in the genomic era

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    La méningo-encéphalite à parvovirus B19 (à propos d un cas et revue de la littérature)

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    Les méningo-encéphalites sont des pathologies graves du système nerveux central. Le diagnostic étiologique non toujours aisé, est fait dans 25 % des cas ; il est souvent infectieux (virale surtout, avec les virus du groupe herpes viridae). Le parpovirus B19, virus ubiquitaire, eset un des derniers à compléter le tableau, ces dernières années. Les connaissances sur son pouvoir pathogène ne cesse de progresser. Reconnu comme agent causal dans le mégalérythème épidémique, l'anasarque foeto-placentaire, l'érythroplastopénie, il est également responsable d'atteintes hépatique, rénale et cardiaque. Son rôle dans certaines maladies auto-immunes est discuté. Son atteinte du système nerveux central est de découverte récente et à ce jour, peu de cas sont décrits. Nous rapportons un cas de méningoencéphalite virale, survenue chez une fille de 16 ans qui conservera des troubles de la personnalité et une épilepsie séquellaire. L'agent causal est le Parpovirus B19 ; diagnostic fait sur une sérologie, et une négativité des autres causes. Ce cas et la revue de la littérature nous permettent d'étayer ses signes cliniques, et les moyens de son diagnostic positif.BORDEAUX2-BU Santé (330632101) / SudocSudocFranceF

    Surgical and Prosthodontic Rehabilitation in a Patient With Freeman-Sheldon Syndrome

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    WOS: 000282003300057PubMed: 20856050Dental and prosthetic rehabilitation possess significant challenges in patients who have Freeman-Sheldon syndrome. Microsomia is one of the main diagnostic criteria for Freeman-Sheldon syndrome, and it creates difficulty in working in the intraoral cavity. Most patients with small orifice often have difficulties in oral hygiene maintenance, and it gives rise to loss of some of the teeth. It incurs the need for dental and oral treatment. In the presented study, the patient with limited mouth opening that disabled the dentists to perform dental treatment was given prosthodontic therapy after having commissuroplasty and implant placement simultaneously

    Comparison of Hyperbaric Levobupivacaine with Hyperbaric Bupivacaine in Unilateral Inguinal Hernia Operations Performed Under Spinal Anesthesia

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    Aim: The aim of this study was to compare hyperbaric bupivacaine used for spinal anesthesia in the patients with inguinal hernia with the same amount of hyperbaric levobupivacaine. Materials and methods: Forty ASAI-II patients, with a unilateral inguinal hernia operation planned under spinal anesthesia by the surgeon, were included in the study. It was planned that the study be prospective and double-blind. The patients were allocated into two groups, each of which had 20 persons allocated randomly. Hyperbaric levobupivacaine and hyperbaric bupivacaine at 3 ml of 0.5% were given into the intrathecal space for groups HL and HD. Perioperative and postoperative blood pressure, peripheral oxygen saturation, and sensorial and motoric block levels of groups were measured. Visual analog scale (VAS) values, side effects and complications were recorded. Results: There were no statistical differences between the groups for age, body weight, body mass index, ASA distributions, and operation period. Peripheral oxygen saturation values during intraoperative 10, 15, 20, 25 and 30 min, and postoperative 30 min, 1, 1.5 and 3 hours were significantly decreased in group HB compared to group HL. The starting of sense block and full motor block time in group HB was found to be significantly short compared to group HB. One patient had hypotension in group HB, and one had intraoperative nausea in group HL. Postoperative urinary retention occurred in two patients in group HB and in one patient in group HL. Conclusions: Hyperbaric levobupivacaine was found to have similar effects to hyperbaric bupivakain for anesthetic effects, hemodynamic parameters, postoperative analgesic necessity time, and the first 24-hour side effects and complications. Levobupivacaine, having a lesser cardiovascular and central nervous system, was suggested as an alternative to bupivacaine. [Arch Clin Exp Surg 2014; 3(1.000): 1-9

    An investigation of the effect of clay type on coal flotation along with DLVO theoretical analyses

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    Coals generally exist with clay minerals, which are very fine-sized minerals, and adversely affect the flotation of coal. For instance, they make the coal surface hydrophilic by coating coal surfaces and therefore, they inhibit bubble-particle attachment. Clay minerals can also cause over-consumption of reagents due to their high surface area. Additionally, clay minerals can transfer into the concentrate during the flotation process by entrainment because of their low weight and small particle size, and thus, increase pulp viscosity and changing froth stability. In this study, the influence of various clay minerals (kaolinite, illite, and bentonite) on the flotation behavior of coal sample was studied in detail by conventional flotation tests. In addition, the values obtained from flotation tests were correlated with theoretical energy barrier values established with classical DLVO theory based on zeta potential values of coal and clay samples measured at different pH values. According to the results of this study, no significant effect of clay minerals was observed on coal flotation. This was probably because of the high floatability of the coal used for this study. Both the results obtained from the experiments and theoretical analysis, DLVO calculations, showed that the type of clay mineral is the main indicator parameter for coal flotation

    Malondialdehyde Levels in Dental Follicles of Asymptomatic Impacted Third Molars

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    KISA, Ucler/0000-0002-8131-6810; Kurku, Huseyin/0000-0002-1083-4151WOS: 000290242300017PubMed: 21256650Purpose: Increased levels of reactive oxygen species lead to oxidative stress and tissue damage. Malondialdehyde (MDA) is one of many low-molecular-weight endproducts of lipid peroxidation that increases with oxidative stress. The aim of this study was to determine oxidative stress in dental follicles (DFs) of radiologically asymptomatic impacted third molars (ITMs) using MDA. Materials and Methods: This study involved 40 DFs of 40 patients referred for clinically and radiographically asymptomatic ITMs. Forty healthy gingival tissues in the same patients were obtained during surgical removal of teeth as a control group. DF widths on periapical radiographs narrower than 2.5 mm were included in the study. All tissues samples were analyzed for MDA as an indicator of oxidative stress. Results: Levels of MDA were significantly higher in DFs from ITMs than those from healthy gingival tissues of the same patients (P < .01). Conclusion: The results suggest that significant oxidative stress may occur in DFs of asymptomatic ITMs. The findings suggest that increased MDA may play an important role in oxidative stress in DFs. In light of these preliminary findings of the present study, further investigations and comprehensive studies are required to determine the role of antioxidants that scavenge free radicals in DFs. (C) 2011 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 69:1291-1294, 201

    Tumor necrosis factor-alpha levels in the synovial fluid of patients with temporomandibular joint internal derangement

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    SALMANOGLU, BERRIN/0000-0003-4344-5782WOS: 000346833400018PubMed: 25465487Purpose: The purpose of this study was to investigate the level of tumor necrosis factor-alpha (TNF-alpha) in the synovial fluid (SF) of patients with temporomandibular joint (TMJ) internal derangement and to show the relationship between the level of TNF-alpha and the severity of the disease. Materials and methods: Arthrocentesis was performed on 32 female and five male patients (aged between 17 and 45) referred to our clinic with the complaint of TMJ pain and discomfort. TNF-alpha levels were determined in the SF samples obtained during arthrocentesis. As a measure of pain, visual analog scale (VAS) scores were also evaluated. Results: There were statistically significant differences in VAS scores between the stages. VAS scores were found to be elevated as the stage of disease progressed. Increased levels of TNF-alpha were found in progressive stages of internal derangement. Conclusion: In our study, both SF TNF-alpha levels and pain levels (VAS scores) were found to be increased in patients with internal derangement as the stage of the disease progresses. TNF-alpha might contribute to the pathogenesis of synovitis and the degeneration of the TMJ cartilage and bone. (C) 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved

    Analysis of flotation and aggregation characteristics of muscovite particles through the extended DLVO theory

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    In this study, the flotation and aggregation characteristics of muscovite mineral particles were determined as a function of dodecyl amine hydrochloride (DAH) concentration and correlated with the theoretically calculated “particle-particle” and “particle-bubble” interactions using extended DLVO theory. In this series of tests, the flotation and aggregation characteristics of the muscovite mineral were determined with micro-flotation and turbidity measurements, respectively. In addition to these analyses, surface tension measurements were carried out as a function of pH. Also, the zeta potential and contact angle measurements were also performed as a function of DAH concentration prior to the flotation and aggregation tests. The experimental studies showed that while almost minimum and maximum points of flotation and turbidity values were obtained up to a critical concentration of DAH as 6.10-6 mol/dm3, a significant increment was obtained following that concentration. Accordingly, while repulsive forces dominated the interactions up to that concentration, the attractive forces became more effective at further concentrations such as 2.10-5, 4.10-5, 8.10-5, and 1.10-4 mol/dm3 DAH concentrations for both “particle-particle” and ”particle-bubble” interactions. This in turn suggested that the determination of energy barrier heights between ”particle-particle” and ”particle bubble” may provide important insights into both flotation and aggregation characteristics of particles

    Relationship Between Activity of Gluthatione Peroxidase and Nitric Oxide in Synovial Fluid and the Progression of Temporomandibular Joint Internal Derangement

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    SALMANOGLU, BERRIN/0000-0003-4344-5782WOS: 000355236700008PubMed: 25974819The purposes of this study were to measure the activity of glutathione peroxidase (GPX) and nitric oxide (NO) in the synovial fluid of patients with temporomandibular joint (TMJ) internal derangement (ID) and to indicate the relationship between the activity of GPX and NO and the progress of the ID. Twenty-six patients with TMJ ID were identified and classified according to Wilkes staging through clinical and radiologic examinations. Levels of GPX were determined indirectly by a coupled reaction with glutathione reductase. Levels of NO were measured colorimetrically. The activity of GPX and NO was observed to be progressively increasing as the stage of the TMJ ID progressed. There were significant correlations between the 2 substances and the Wilkes stages. Oxidative stress may have a role in the pathogenesis of TMJ ID. In synovial fluid, GPX and NO activities are increased as the stage of the disease increased. Increase in the activities of GPX might not be enough to prevent progression of the TMJ ID
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