5 research outputs found

    A model for humanitarian supply chain: An operation research approach

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    © 2018 The Authors. Published by Elsevier Ltd. The study presents a mathematical model for identification of the optimum location of a temporary or fixed facility in a certain geographic area being studied. Particularly, it is applied to Humanitarian Supply Chain where it seeks to identify the best location of temporary relief center operations in order to optimize the delivery of relief goods to the randomly dispersed evacuation centers. The paper seeks to optimize the movement of relief goods by minimizing the total transportation cost using Operation Research approach with the integration of Center of Gravity method. The center of gravity approach aims to locate a facility where it reflects equality of distances and demand volume in a network of customers\u27 locations. A case study was applied to use the model. The results revealed the geographic coordinates of the optimum location of the facility. The identified optimum location will have a total savings of 40% in the total transportation cost. Hence, by a significant reduction of the transportation cost will also mean a significant reduction of response time and delivery time of relief goods because these transportation cost are functions of distances of customers location and a function of volume of customers\u27 demand. The identified optimum facility location could also be a prepositioned location of relief goods covering the affected areas in the city. The proposed model for disaster facility location is easy to use and require simple tasks to implement. The model is readily accessible to managers and planners so it can be used in their planning

    A developed mobile application for optimum facility location using center of gravity approach

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    This research is about the development, testing and application of mobile app for optimum location spot of a single facility. The approach is to use Center of Gravity Method to locate the central locations of the facility. This equality would reflect balance and minimum time and cost. The main variables to be considered in the systems are customer\u27s distance, customer\u27s demands and transportation rates. In general, firms which apply technologies will perform significantly better than those that do not. This leads to the development of a mobile app to identify best location for a single facility which will serve several demand centers. After the development of a mobile app, this undergoes testing which includes verification whether the mobile app will provide the same result in theoretical computations. The study confirms that the mobile app is consistent with the theoretical computations for location planning. This mobile app becomes a decision support system suggesting that they can access this mobile app to improve the firm\u27s performance on decision making. A faster and effective decision making since instead of manual computation which will take time, the computation will be in a few seconds plus you could visualize the geographic areas being investigated. Moreover, the mobile app is practical to implement because it is flexible and easy to use. The data needed is easy to gather. The mobile app can generate up to 100 iterations to ensure that global maxima is obtained. © 2018 IEEE

    Specific changes in the expression of imprinted genes in prostate cancer—implications for cancer progression and epigenetic regulation

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    Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: One-Year Follow-up.

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    BACKGROUND AND OBJECTIVES Declines in stroke admission, intravenous thrombolysis, and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the impact of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), intravenous thrombolysis (IVT), and mechanical thrombectomy over a one-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020). METHODS We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, intravenous thrombolysis treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. RESULTS There were 148,895 stroke admissions in the one-year immediately before compared to 138,453 admissions during the one-year pandemic, representing a 7% decline (95% confidence interval [95% CI 7.1, 6.9]; p<0.0001). ICH volumes declined from 29,585 to 28,156 (4.8%, [5.1, 4.6]; p<0.0001) and IVT volume from 24,584 to 23,077 (6.1%, [6.4, 5.8]; p<0.0001). Larger declines were observed at high volume compared to low volume centers (all p<0.0001). There was no significant change in mechanical thrombectomy volumes (0.7%, [0.6,0.9]; p=0.49). Stroke was diagnosed in 1.3% [1.31,1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82,2.97], 5,656/195,539) of all stroke hospitalizations. DISCUSSION There was a global decline and shift to lower volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared to the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year. TRIAL REGISTRATION INFORMATION This study is registered under NCT04934020

    Global Impact of COVID-19 on Stroke Care and IV Thrombolysis

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    Objective To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. Methods. We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. Results. There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95% confidence interval [CI] −11.7 to −11.3, p \u3c 0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 11,570 procedures during the pandemic, representing a 13.2% (95% CI −13.8 to −12.7, p \u3c 0.0001) drop. Interfacility IVT transfers decreased from 1,337 to 1,178, or an 11.9% decrease (95% CI −13.7 to −10.3, p = 0.001). Recovery of stroke hospitalization volume (9.5%, 95% CI 9.2–9.8, p \u3c 0.0001) was noted over the 2 later (May, June) vs the 2 earlier (March, April) pandemic months. There was a 1.48% stroke rate across 119,967 COVID-19 hospitalizations. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was noted in 3.3% (1,722/52,026) of all stroke admissions. Conclusions. The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID-19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months
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