Evaluation and optimization of the Sysmex UF1000i system for the screening of urinary tract infection in primary health care elderly patients

Objective Urinary tract infections (UTIs) are a common problem in the elderly population. Urine culture is still considered the "gold standard" to diagnose infection in this population. However, urine cultures are laborious and costly, and most samples will yield no growth. Methods An evaluation was made of the Sysmex UF-1000i flow cytometer as a screening tool for UTI in an elderly population older than 65 years who lived in the community, using 346 urine samples submitted for culture. Results The Receiver Operating Characteristic (ROC) analysis showed a significant difference (P < 0.01) between 0.98 bacteria area under the curve value and 0.82 of white blood cells (WBC). The combination of both counts for screening did not show any improvement in specificity or sensitivity. According to our data, the use of a single cut-off point of 200 bacteria/μL is suggested, in which the sensitivity and specificity were 99.11% and 91.59%, respectively, with a NPV of 99.49%. Moreover, this cut-off value could avoid 60.24% of the samples to be cultured, with a minimal false negative results rate of 0.87%. Conclusions The stratification of age groups stratification helps in selecting a more adjusted Sysmex UF1000i cut-off limit, leading to an improvement in the screening parameters that would imply a better management of these infections, as well as a high reduction in the workload and cost savings

COSMOSOMAS Observations of the CMB and Galactic Foregrounds at 11 GHz: Evidence for anomalous microwave emission at high Galactic Latitude

We present observations with the new 11 GHz radiometer of the COSMOSOMAS experiment at the Teide Observatory (Tenerife). The sky region between 0 deg <= RA <= 360 deg and 26 deg <= DEC 49 deg (ca. 6500 square degrees) was observed with an angular resolution of 0.9 deg. Two orthogonal independent channels in the receiving system measured total power signals from linear polarizations with a 2 GHz bandwidth. Maps with an average sensitivity of 50 microK per beam have been obtained for each channel. At high Galactic latitude (|b|>30deg) the 11 GHz data are found to contain the expected cosmic microwave background as well as extragalactic radiosources, galactic synchrotron and free-free emission, and a dust-correlated component which is very likely of galactic origin. At the angular scales allowed by the window function of the experiment, the dust-correlated component presents an amplitude \Delta T aprox. 9-13 microK while the CMB signal is of order 27 microK. The spectral behaviour of the dust-correlated signal is examined in the light of previous COSMOSOMAS data at 13-17 GHz and WMAP data at 22-94 GHz in the same sky region. We detect a flattening in the spectral index of this signal below 20 GHz which rules out synchrotron radiation as being responsible for the emission. This anomalous dust emission can be described by a combination of free-free emission and spinning dust models with a flux density peaking around 20 GHz.Comment: 17 pages, 10 tables, 20 figures. Details on the COSMOSOMAS experiment can be found at http://www.iac.es/project/cmb/cosmosomas

Modeling at farm level: Positive Multi-Attribute Utility Programming

This article proposes a new mathematical programming model for the simulation of farmers’ decision-making. We have developed a model based on a multi-attribute utility approach that takes into consideration the most relevant attributes of farmers within a positive framework. This approach overcomes the limitations found in some mathematical models used in the literature to simulate farmers’ behavior. A five-step procedure is presented in order to elicit the utility function that reproduces farmers’ current decision-making. We illustrate this positive multi-attribute approach using a sample of farmers in an irrigated area in southern Spain, where our simulations demonstrate the accurateness of the model in reproducing actual farmers’ decision-making. We also find evidence that the model is able to explain the heterogeneous behavior of farmers within a homogeneous agricultural syste

A Practical Environment to Apply Model-Driven Web Engineering

The application of a model-driven paradigm in the development of Web Systems has yielded very good research results. Several research groups are defining metamodels, transformations, and tools which offer a suitable environment, known as model-driven Web engineering (MDWE). However, there are very few practical experiences in real Web system developments using real development teams. This chapter presents a practical environment of MDWE based on the use of NDT (navigational development techniques) and Java Web systems, and it provides a practical evaluation of its application within a real project: specialized Diraya.Ministerio de Educación y Ciencia TIN2007-67843-C06-03Ministerio de Educación y Ciencia TIN2007-30391-

Retos y oportunidades de la implantación de los bancos de agua en España

Con el fin de conseguir una buena gobernanza del agua, que trate de alcanzar un equilibrio entre los objetivos de eficiencia económica y sostenibilidad ambiental, durante las últimas décadas se ha potenciado el uso de instrumentos económicos para una mejor gestión de la demanda de los recursos hídricos, dada la dificultad de seguir aumentando la oferta de los mismos. En este contexto, este trabajo se centra en los bancos de agua como mecanismo de mercado que aporta la necesaria flexibilidad institucional en la asignación de los recursos hídricos entre los diferentes usuarios. La investigación realizada en este sentido ha permitido desarrollar una tipología de los bancos de agua que actualmente operan a nivel mundial en base a sus características operativas. Esta caracterización ha permitido igualmente realizar un análisis crítico de las experiencias de bancos de agua implementadas hasta la fecha, con el fin poder valorar el desempeño de este instrumento económico para la mejora de la gestión pública del agua. La investigación llevada a cabo revela que los bancos de agua son un instrumento útil para la gestión de los recursos hídricos, aportando sugerencias para la mejora de su implementación operativa en España mediante la correspondiente reforma de la Ley de Aguas.Ministerio de Economía y Competitividad (MINECO) AGL2013-48080-C2-1-RFondo Europeo de Desarrollo Regional (FEDER) AGL2013-48080-C2-1-

Wind intermittency and CO2 reductions: the case of the spanish power system

Renewable energy sources are believed to reduce drastically greenhouse gas emissions that would otherwise be generated from fossil fuels used to generate electricity. This implies that a unit of renewable energy will replace a unit of fossil-fuel, with its CO2 emissions, on an equivalent basis (with no other effects on the grid). But, the fuel economy and emissions in the existing power systems are not proportional with the electricity production of intermittent sources due to cycling of the fossil fuel plants that make up the balance of the grid (i.e. changing the power output makes thermal units to operate less efficiently). This study focuses in the interactions between wind generation and thermal plants cycling, by establishing the levels of extra fuel use caused by decreased efficiencies of fossil back-up for wind electricity in Spain. We analyze the production of all thermal plants in 2011, studying different scenarios where wind penetration causes major deviations in programming, while we define a procedure for quantifying the carbon reductions by using emission factors and efficiency curves from the existing installations. The objectives are to discuss the real contributions of renewable energies to the environmental targets as well as suggest alternatives that would improve the reliability of future power systems

Priority Water Rights for Irrigation at the River Basin Level. Do They Improve Economic Efficiency During Drought Periods?

This paper assesses the potential efficiency gains of reforming the water rights regime in the Spanish agricultural sector by replacing current allocation procedures based on the proportional rule with a priority allocation procedure based on two tiers of security-differentiated water rights. This assessment is useful for evaluating whether said change in water rights can be considered a suitable policy instrument to improve water management during droughts events. For this purpose, a mathematical programming model is built to simulate the performance of the proposed reform. The empirical analysis is implemented at the basin scale, where water rights holders are highly heterogeneous, considering different climate scenarios accounting for changes in water supply reliability. The Guadalquivir River Basin (GRB) in southern Spain is used as a case study. The results obtained show that this change in the water allocation regime would yield only modest economic efficiency gains under the current climate scenario. However, it is also evidenced that this policy instrument could play a more relevant role as an efficiency enhancer in a climate change scenario, given that more frequent and intense drought episodes are expected. Moreover, priority rights represent an interesting risk management instrument for farmers, allowing the most vulnerable farmers to reduce income volatility. These findings suggest that the combined implementation of the proposed shift in the allocation regime with spot or allocation water markets would lead to successful outcomes, significantly improving drought management in the irrigation sector

Priority water rights. Are they useful for improving water-use efficiency at the irrigation district level?

This paper examines the effectiveness of reforming water rights regimes in the agricultural sector by replacing allocation procedures based on the proportional rule with the implementation of a priority rule that establishes security-differentiated water rights. The main objective is to assess whether this change improves the economic efficiency of water allocation at the irrigation district level, particularly during cyclical scarcity events. To this end, a Positive Mathematical Programming model is built to simulate the performance of the proposed reform in an irrigation district in southern Spain. The results show that the efficiency gains brought about by this change are very small, which casts doubt on its ability to improve water-use efficiency in the agricultural sector at the local level (i.e., irrigation district) under current local climate and water availability conditions. In any case, further research is needed to assess the suitability of this change in allocations rules at basin scale with greater farm heterogeneity, especially given the likelihood of more frequent, more intense droughts due to climate change

Agricultural Water Allocation Under Cyclical Scarcity: The Role of Priority Water Rights

Water is becoming an increasingly scarce resource worldwide, suggesting that water rationing methods should be revised to improve water allocation efficiency, especially during cyclical scarcity events (droughts). The proportional rule is the most widely used rationing method to allocate water in cases of water scarcity. However, this method fails to achieve Pareto-efficient allocation arrangements. Economic theory and international experience demonstrate that implementing security-differentiated water rights could improve allocative efficiency during cyclical scarcity periods. Moreover, it has been proven that this kind of priority rights regime is an efficient instrument to share risks related to water supply reliability, and can thus be considered as an adaptation measure to climate change. This evidence has enabled the development of an operational proposal for the implementation of security-differentiated water rights in the irrigation sector in Spain, as an alternative to the current rights based on the proportional rule. This proposal draws on the Australian case study, which is the most successful experience worldwide. Nevertheless, the insights obtained from the analysis performed and the proposal for reforming the water rights regime are applicable to any country with a mature water economy

Self-financed water bank for resource reallocation to the environment and within the agricultural sector

In closed river basins, economic activities commonly threaten instream flows, especially during drought episodes. In such situations, a suitable policy option is to recover water for the environment by purchasing water allocations from farmers through a water bank. However, the purchase of temporary water rights strongly depends on the public budget available for this purpose. We propose a self-financed water bank with the twofold objective of reallocating water within the agricultural sector and recovering a share of the purchased water for the environment. The main feature of this water bank is that it will operate in a monopsony-monopoly setting, using its market power to recover water for environmental purposes, and working with a balanced budget (expenditure on purchases will equal revenues from sales). A mathematical programming model is developed to simulate the potential performance of the proposed water bank in the Guadalquivir River Basin (southern Spain), considering society’s demand for environmental water and different water scarcity scenarios. Results show that a maximum of between 5.8% and 10.4% of total water availability can be recovered for the environment, depending on the severity of the drought, while total economic efficiency is increased, yielding a beneficial result for farmers and society