Estudio de identificación de las falencias en actitudes del personal frente al clima organizacional del proceso de compras institucionales de la empresa Comfamiliar de Risaralda de la ciudad de Pereira

No aplicaEl clima organizacional según el autor García “es el conjunto de cualidades, atributos o propiedades, relativamente permanentes de un ambiente de trabajo concreto, que son percibidas, sentidas o experimentadas por las personas que componen la organización y que influyen sobre su conducta”. Una vez entendida la importancia y el impacto que genera el clima organizacional en todas las empresas, se busca que por medio de esta investigación y el debido análisis de la información de la empresa Caja de Compensación Familiar Comfamiliar Risaralda, determinar el estado actual del ambiente laboral en el proceso de Compras Institucionales, esto con el fin de plantear un proceso de plan de mejora que permita accionar actividades que satisfacer las necesidades de los colaboradores a nivel de bienestar laboral y así impactar de manera positiva el objetivo del proceso y la empresa.The organizational climate according to the author Garcia "is the set of qualities, attributes or properties, relatively permanent of a particular work environment, which are perceived, felt or experienced by the people who make up the organization and that influence their behavior". Once understood the importance and the impact that generates the organizational climate in all companies, it is sought that through this research and the due analysis of the information of the company Caja de Compensación Familiar Comfamiliar Risaralda, determine the current state of the work environment in the process of Institutional Purchasing, this in order to propose a process improvement plan that allows to implement activities that meet the needs of employees at the level of labor welfare and thus positively impact the objective of the process and the company

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality