Sliding Blocks Revisited: A simulational Study

A computational study of sliding blocks on inclined surfaces is presented. Assuming that the friction coefficient $\mu$ is a function of position, the probability $P(\lambda)$ for the block to slide down over a length $\lambda$ is numerically calculated. Our results are consistent with recent experimental data suggesting a power-law distribution of events over a wide range of displacements when the chute angle is close to the critical one, and suggest that the variation of $\mu$ along the surface is responsible for this.Comment: 6 pages, 4 figures. submitted to Int. J. Mod. Phys. (Proc. Brazilian Wokshop on Simulational Physics

Akute Barbitalwirkungen auf den Protein- und Nucleinsäurestoffwechsel der Rattenleber

Peer Reviewe

The EUROclass trial: defining subgroups in common variable immunodeficiency

The heterogeneity of common variable immunodeficiency (CVID) calls for a classification addressing pathogenic mechanisms as well as clinical relevance. This European multicenter trial was initiated to develop a consensus of 2 existing classification schemes based on flowcytometric B-cell phenotyping and the clinical course. The clinical evaluation of 303 patients with the established diagnosis of CVID demonstrated a significant coincidence of granulomatous disease, autoimmune cytopenia, and splenomegaly. Phenotyping of B-cell subpopulations confirmed a severe reduction of switched memory B cells in most of the patients that was associated with a higher risk for splenomegaly and granulomatous disease. An expansion of CD21(low) B cells marked patients with splenomegaly. Lymphadenopathy was significantly linked with transitional B-cell expansion. Based on these findings and pathogenic consideration of B-cell differentiation, we suggest an improved classification for CVID (EUROclass), separating patients with nearly absent B cells (less than 1%), severely reduced switched memory B cells (less than 2%), and expansion of transitional (more than 9%) or CD21(low) B cells (more than 10%). Whereas the first group contains all patients with severe defects of early B-cell differentiation, severely reduced switched memory B cells indicate a defective germinal center development as found in inducible constimulator (ICOS) or CD40L deficiency. The underlying defects of expanded transitional or CD21(low) B cells remain to be elucidated. This trial is re-gistered at http://www.uniklinik-freiburg.de/zks/live/ukiregister/Oeffentlich.html as UKF000308