8,914 research outputs found
Quantum information processing with space-division multiplexing optical fibres
The optical fibre is an essential tool for our communication infrastructure
since it is the main transmission channel for optical communications. The
latest major advance in optical fibre technology is spatial division
multiplexing (SDM), where new fibre designs and components establish multiple
co-existing data channels based on light propagation over distinct transverse
optical modes. Simultaneously, there have been many recent developments in the
field of quantum information processing (QIP), with novel protocols and devices
in areas such as computing, communication and metrology. Here, we review recent
works implementing QIP protocols with SDM optical fibres, and discuss new
possibilities for manipulating quantum systems based on this technology.Comment: Originally submitted version. Please see published version for
improved layout, new tables and updated references following review proces
Linear stability of Einstein-Gauss-Bonnet static spacetimes. Part I: tensor perturbations
We study the stability under linear perturbations of a class of static
solutions of Einstein-Gauss-Bonnet gravity in dimensions with spatial
slices of the form \Sigma_{\k}^n \times {\mathbb R}^+, \Sigma_{\k}^n an
manifold of constant curvature \k. Linear perturbations for this class of
space-times can be generally classified into tensor, vector and scalar types.
The analysis in this paper is restricted to tensor perturbations.Comment: 14 pages, 4 figure
Biomedical Informatics Applications for Precision Management of Neurodegenerative Diseases
Modern medicine is in the midst of a revolution driven by “big data,” rapidly advancing computing power, and broader integration of technology into healthcare. Highly detailed and individualized profiles of both health and disease states are now possible, including biomarkers, genomic profiles, cognitive and behavioral phenotypes, high-frequency assessments, and medical imaging. Although these data are incredibly complex, they can potentially be used to understand multi-determinant causal relationships, elucidate modifiable factors, and ultimately customize treatments based on individual parameters. Especially for neurodegenerative diseases, where an effective therapeutic agent has yet to be discovered, there remains a critical need for an interdisciplinary perspective on data and information management due to the number of unanswered questions. Biomedical informatics is a multidisciplinary field that falls at the intersection of information technology, computer and data science, engineering, and healthcare that will be instrumental for uncovering novel insights into neurodegenerative disease research, including both causal relationships and therapeutic targets and maximizing the utility of both clinical and research data. The present study aims to provide a brief overview of biomedical informatics and how clinical data applications such as clinical decision support tools can be developed to derive new knowledge from the wealth of available data to advance clinical care and scientific research of neurodegenerative diseases in the era of precision medicine
Central mechanisms mediating the hypophagic effects of oleoylethanolamide and N-acylphosphatidylethanolamines: different lipid signals?
The spread of "obesity epidemic" and the poor efficacy of many anti-obesity therapies in the long-term highlight the need to develop novel efficacious therapy. This necessity stimulates a large research effort to find novel mechanisms controlling feeding and energy balance. Among these mechanisms a great deal of attention has been attracted by a family of phospholipid-derived signaling molecules that play an important role in the regulation of food-intake. They include N-acylethanolamines (NAEs) and N-acylphosphatidylethanolamines (NAPEs). NAPEs have been considered for a long time simply as phospholipid precursors of the lipid mediator NAEs, but increasing body of evidence suggest a role in many physiological processes including the regulation of feeding behavior. Several observations demonstrated that among NAEs, oleoylethanolamide (OEA) acts as a satiety signal, which is generated in the intestine, upon the ingestion of fat, and signals to the central nervous system. At this level different neuronal pathways, including oxytocinergic, noradrenergic, and histaminergic neurons, seem to mediate its hypophagic action. Similarly to NAEs, NAPE (with particular reference to the N16:0 species) levels were shown to be regulated by the fed state and this finding was initially interpreted as fluctuations of NAE precursors. However, the observation that exogenously administered NAPEs are able to inhibit food intake, not only in normal rats and mice but also in mice lacking the enzyme that converts NAPEs into NAEs, supported the hypothesis of a role of NAPE in the regulation of feeding behavior. Indirect observations suggest that the hypophagic action of NAPEs might involve central mechanisms, although the molecular target remains unknown. The present paper reviews the role that OEA and NAPEs play in the mechanisms that control food intake, further supporting this group of phospholipids as optimal candidate for the development of novel anti-obesity treatments
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