Equal or Just? Intergenerational Allocations within Family Farm Businesses

A multi-disciplinary literature review was conducted in order to integrate multiple perspectives pertaining to family farm business transfer. Factors affecting perceptions of equality in family farm transfers were identified. Preliminary survey results analyze perceptions of equality within farm families and how these perceptions affect family farm transfer planning and implementation.family farm succession, intergenerational transfer, Farm Management, Q10, Q12,

The development of a 14-day non-viral engineered CAR T-cell process

Immunotherapy utilizing chimeric antigen receptor (CAR) T cells is a promising strategy for the treatment of several types of cancer. Many preclinical and clinical studies engineer CAR T cells through a viral vector, presenting the potential for genotoxicity or insertional mutagenesis. We propose a 14-day non-viral process where we introduce the gene of interest via electroporation; integration can be achieved with the Sleeping Beauty transposon system. Minicircle (MC) DNA constructs containing the CAR, a surface marker (EGFRt), and a double mutant of dihydrofolate reductase (DHFRdm) are electroporated into previously frozen, unstimulated CD4/CD8 T cells with an RNA construct coding for the Sleeping Beauty transposase. After electroporation, cells are bead-stimulated with CD3/CD28 without the use of feeder cells throughout the process. CAR+ cells expressing DHFRdm are rendered insensitive to an FDA-approved small molecule drug, methotrexate (MTX), which allows for chemical selection of the cells of interest while avoiding a magnetic bead sort. The entire process is completed in 2 weeks with a media formulation that contains a serum-free replacement. Please click Additional Files below to see the full abstract

Investigating Causal DIF via Propensity Score Methods

A variety of differential item functioning (DIF) methods have been proposed and used for ensuring that a test is fair to all test takers in a target population in the situations of, for example, a test being translated to other languages. However, once a method flags an item as DIF, it is difficult to conclude that the grouping variable (e.g., test language) is responsible for the DIF result because there may exist many confounding variables that lead to the DIF result. The present study aims to (i) demonstrate the application of propensity score methods in psychometric research on DIF for day-to-day researchers, and (ii) describe conditional logistic regression for matched data in a DIF context. Propensity score methods can help to achieve the comparability between different populations or groups with respect to participants’ pre-test differences, which can assist in examining the validity of making a causal claim with regard to DIF. Accessed 3,183 times on https://pareonline.net from December 20, 2016 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right

Origin and evolution of the zodiacal dust cloud

The astrophysical importance of the zodiacal cloud became more apparent. The most useful source of information on the structure of the zodiacal cloud is the Infrared Astronomical Satellite (IRAS) observations. A substantial fraction of the extensive IRAS data set was analyzed. Also, a numerical model was developed (SIMUL) that allows to calculate the distribution of night-sky brightness that would be produced by any particular distribution of dust particle orbits. This model includes the effects of orbital perturbations by both the planets and solar radiation, it reproduces the exact viewing geometry of the IRAS telescope, and allows for the eccentricity of the Earth's orbit. SIMUL now is used to model not just the solar system dust bands discovered by IRAS but the whole zodiacal cloud

Quasi-analytical solutions for APSIDAL motion in the three-body problem: Sun—minor planet—Jupiter

This paper deals with the effect of a third body on the apsidal motion of two bodies. The specific case involves a third body-planet Jupiter and the apsidal line motion of a minor planet that orbits the Sun and has its apsidal line go through the major axis of an ellipse. The third body (Jupiter) which satisfies the Langrangian solution will affect the apsidal line motion and therefore affects the ascending and descending motions of the minor planet. In this case no analytical solutions can be obtained, and therefore specific assumptions are made along with numerical solutions. For convenience, we adopt the Lagrangian solution in the three-body problem and obtain quasi-analytical results, which are used to evaluate the effect of the planet on the d Omega/dt (Omega ascending node) of each minor planet. This method is beneficial for improving our knowledge of the orbital elements of the asteroids, and perhaps even much smaller effects such as the effects of the planets on the interplanetary dust complex. Information on the latter may be provided by using this method to investigate Jupiter\u27s effect on the inclination of the symmetry surface of the zodiacal dust cloud

Evaluating the pronunciation component of text-to-speech systems for English: A performance comparison of different approaches

The automatic derivation of word pronunciations from input text is a central task for any text-to-speech system. For general English text at least, this is often thought to be a solved problem, with manually-derived linguistic rules assumed capable of handling `novel' words missing from the system dictionary. Data-driven methods, based on machine learning of the regularities implicit in a large pronouncing dictionary, have received considerable attention recently but are generally thought to perform less well. However, these tentative beliefs are at best uncertain without powerful methods for comparing text-to-phoneme subsystems. This paper contributes to the development of such methods by comparing the performance of four representative approaches to automatic phonemisation on the same test dictionary. As well as rule-based approaches, three data-driven techniques are evaluated: pronunciation by analogy (PbA), NETspeak and IB1-IG (a modified k-nearest neighbour method). Issues involved in comparative evaluation are detailed and elucidated. The data-driven techniques outperform rules in accuracy of letter-to-phoneme translation by a very significant margin but require aligned text-phoneme training data and are slower. Best translation results are obtained with PbA at approximately 72% words correct on a reasonably large pronouncing dictionary, compared to something like 26% words correct for the rules, indicating that automatic pronunciation of text is not a solved problem

The origin and evolution of the zodiacal dust cloud

We have now analyzed a substantial fraction of the IRAS observations of the zodiacal cloud, particularly in the 25 micron waveband. We have developed a gravitational perturbation theory that incorporates the effects of Poynting-Robertson light drag (Gomes and Dermott, 1992). We have also developed a numerical model, the SIMUL mode, that reproduces the exact viewing geometry of the IRAS telescope and calculates the distribution of thermal flux produced by any particular distribution of dust particle orbits (Dermott and Nicholson, 1989). With these tools, and using a distribution of orbits based on those of asteroidal particles with 3.4 micron radii whose orbits decay due to Poynting-Robertson light drag and are perturbed by the planets, we have been able to: (1) account for the inclination and node of the background zodiacal cloud observed by IRAS in the 25 micron waveband; (2) relate the distribution of orbits in the Hirayama asteroid families to the observed shapes of the IRAS solar system dustbands; and (3) show that there is observational evidence in the IRAS data for the transport of asteroidal particles from the main belt to the Earth by Poynting-Robertson light drag

Thermal noise in half infinite mirrors with non-uniform loss: a slab of excess loss in a half infinite mirror

We calculate the thermal noise in half-infinite mirrors containing a layer of arbitrary thickness and depth made of excessively lossy material but with the same elastic material properties as the substrate. For the special case of a thin lossy layer on the surface of the mirror, the excess noise scales as the ratio of the coating loss to the substrate loss and as the ratio of the coating thickness to the laser beam spot size. Assuming a silica substrate with a loss function of 3x10-8 the coating loss must be less than 3x10-5 for a 6 cm spot size and a 7 micrometers thick coating to avoid increasing the spectral density of displacement noise by more than 10%. A similar number is obtained for sapphire test masses.Comment: Passed LSC (internal) review. Submitted to Phys. Rev. D. (5/2001) Replacement: Minor typo in Eq. 17 correcte

Brownian Thermal Noise in Multilayer Coated Mirrors

We analyze the Brownian thermal noise of a multi-layer dielectric coating, used in high-precision optical measurements including interferometric gravitational-wave detectors. We assume the coating material to be isotropic, and therefore study thermal noises arising from shear and bulk losses of the coating materials. We show that coating noise arises not only from layer thickness fluctuations, but also from fluctuations of the interface between the coating and substrate, driven by internal fluctuating stresses of the coating. In addition, the non-zero photoeleastic coefficients of the thin films modifies the influence of the thermal noise on the laser field. The thickness fluctuations of different layers are statistically independent, however, there exists a finite coherence between layers and the substrate-coating interface. Taking into account uncertainties in material parameters, we show that significant uncertainties still exist in estimating coating Brownian noise.Comment: 26 pages, 18 figure

Body mass index, mini nutritional assessment, and their association with five-year mortality in very old people

Objectives: To investigate the prevalence of malnutrition and the association between Body Mass Index (BMI), Mini Nutritional Assessment (MNA) and five-year mortality in a representative population of very old (>85 years) people. Design: A prospective cohort study. Setting: A population-based study of very old people in northern Sweden and western Finland, living in institutional care or in the community. Participants: Out of 1195 potential participants, 832 were included (mean age 90.2[+ or -]4.6 years). Measurements: Nutritional status was assessed using BMI and MNA and the association of those two variables with five-year mortality was analyzed. Results: The mean BMI value for the whole population was 25.1[+ or -]4.5 kg/m2, with no difference between genders (P=0.938). The mean MNA score was 22.5[+ or -]4.6 for the whole sample, and it was lower for women than for men (PA<0.001). Thirteen percent were malnourished (MNA<17) and 40.3% at risk of malnutrition (MNA 17--23.5) according to MNA. Also, 34.8% of those with a MNA score A<17 still had a BMI value a[yen]22.2 kg/m2. A BMI value A<22.2 kg/m2 and a MNA scoreA<17 were associated with lower survival. The association with mortality seemed to be J-shaped for BMI, and linear for MNA. Conclusions: Malnutrition according to MNA was common, but a substantial portion of those with a low MNA score still had a high BMI value, and vice versa. The association with mortality appeared to be J-shaped for BMI, and linear for MNA. The MNA seems to be a good measurement of malnutrition in very old people, and BMI might be misleading and could underestimate the prevalence of malnutrition, especially in women