Vacuolization of hematopoietic precursors: an enigma with multiple etiologies

Cytoplasmic vacuoles in precursors can be seen in a number of clinical settings, including copper deficiency, zinc toxicity, alcohol abuse, antibiotic treatment, myelodysplasia, and VEXAS syndrome. Gurnari et al asked how common VEXAS syndrome is in patients whose bone marrow aspirates show this distinctive feature, finding 2 diagnoses of VEXAS among 24 cases with vacuoles

TET2 mutations as a part of DNA dioxygenase deficiency in myelodysplastic syndromes

Decrease in DNA dioxygenase activity generated by TET2 gene family is crucial in myelodysplastic syndromes (MDS). The general downregulation of 5-hydroxymethylcytosine (5-hmC) argues for a role of DNA demethylation in MDS beyond TET2 mutations, which albeit frequent, do not convey any prognostic significance. We investigated TETs expression to identify factors which can modulate the impact of mutations and thus 5-hmC levels on clinical phenotypes and prognosis of MDS patients. DNA/RNA-sequencing and 5-hmC data were collected from 1665 patients with MDS and 91 controls. Irrespective of mutations, a significant fraction of MDS patients exhibited lower TET2 expression, whereas 5-hmC levels were not uniformly decreased. In searching for factors explaining compensatory mechanisms, we discovered that TET3 was upregulated in MDS and inversely correlated with TET2 expression in wild type cases. Although TET2 was reduced across all age groups, TET3 levels were increased in a likely feedback mechanism induced by TET2 dysfunction. This inverse relationship of TET2 and TET3 expression also corresponded to the expression of L-2-hydroxyglutarate dehydrogenase, involved in agonist/antagonist substrate metabolism. Importantly, elevated TET3 levels influ-enced the clinical phenotype of TET2 deficiency whereby the lack of compensation by TET3 (low TET3 expression) was associated with poor outcomes of TET2 mutant carriers

Mathematics in Medical Diagnostics - 2022 Proceedings of the 4th International Conference on Trauma Surgery Technology

The 4th event of the Giessen International Conference Series on Trauma Surgery Technology took place on April, the 23rd 2022 in Warsaw, Poland. It aims to bring together practical application research, with a focus on medical imaging, and the TDA experts from Warsaw. This publication contains details of our presentations and discussions

Clinical and genomic-based decision support system to define the optimal timing of allogeneic hematopoietic stem-cell transplantation in patients with myelodysplastic syndromes

Statistical Scienc

UKF-based fault detection and isolation algorithm for IMU sensors of Unmanned Underwater Vehicles

Sensor fault detection and isolation (SFDI) is a fundamental topic in unmanned underwater vehicles (UUV) development, since control system reliability strongly depends on the accuracy of attitude estimation. In small UUVs, typical redundant architectures, based on triplex redundancy, can represent a strong limitation in terms of payload and power consumption. This work proposes an FDI algorithm for small UUVs equipped with duplex sensor architecture. Here, attitude estimation relies upon the usage of two 9-DoF inertial measurement units (IMUs) including 3-axis accelerometers, gyroscopes and magnetometers. The proposed SFDI algorithm is based on an unscented Kalman filter (UKF) approach to efficiently detect and isolate faulted IMU sensors. Its effectiveness and robustness were proved through experimental tests involving realistic faults on a real underwater vehicle. A sensitivity analysis was carried out on the relevant algorithm parameters in order to find a trade-off between performance, computational burden and reliability

OxCOVID19 Database, a multimodal data repository for better understanding the global impact of COVID-19

Oxford COVID-19 Database (OxCOVID19 Database) is a comprehensive source of information related to the COVID-19 pandemic. This relational database contains time-series data on epidemiology, government responses, mobility, weather and more across time and space for all countries at the national level, and for more than 50 countries at the regional level. It is curated from a variety of (wherever available) official sources. Its purpose is to facilitate the analysis of the spread of SARS-CoV-2 virus and to assess the effects of non-pharmaceutical interventions to reduce the impact of the pandemic. Our database is a freely available, daily updated tool that provides unified and granular information across geographical regions. Design type Data integration objective Measurement(s) Coronavirus infectious disease, viral epidemiology Technology type(s) Digital curation Factor types(s) Sample characteristic(s) Homo sapiens

Recurrent Sweet's syndrome in a patient with multiple myeloma

We report on a case of Sweet's syndrome associated with multiple myeloma, as harbinger for disease relapse