New approaches of morfofunktional pharmacological correction of violations of cardiovascular system in experimental preeclampsia

Experimental Modeling ADMA-like preeclampsia administration to rats was performed by Nnitro-L-arginine methyl ester, from 14 to 20 days of pregnancy. The animals were observed increase in blood pressure, proteinuria, impaired microcirculation in the placenta, the violation of the regulation of vascular tone and destructive changes in the placenta of ischemic origin. Introduction of tetrahydrobiopterin, a selective inhibitor of arginase II of, recombinant erythropoietin, tadalafil, erythromycin, azithromycin, and playback systems polivitaminnomineralnyh distant ischemic preconditioning resulted in a pronounced correction of morphological and functional disorders arise when modeling the experimental preeclampsi

Experimental studies of impact of exhaust gas recirculation on the effective operation in heavy augmented diesel engine

This paper considers the problem of reducing the nitrogen oxides emissions in exhaust gases (EG) of diesel engine by exhaust gas recirculation (EGR). Based on the carried out study the influence of EGR on technical-and-economic and environmental performance of a diesel engine was found as well as main directions of improving a working process of diesel engines with EGR system were formulated.Keywords: diesel engine, warm-up mode, exhaust toxicity, exhaust gas recirculation, nitrogen oxides (NOx), heat exchanger of system exhaust gas recirculatio

OSCILLATOR temporality FACTORS implementation of innovative activity of economic entities

Presents arguments justifying the need of accounting for temporary (temporal) factor in the management of innovation. Given modern interpretation of the innovation process from the standpoint of transdisciplinary scientific approach. The proposed mechanism of formation of the oscillator susceptibility of the entity to innovate

EVOLUTION OFDEFINITIONS «innovation» in the theory ofeconomic schools

Annоtation. The article describes the process of definition of «Innovation» as an object of scientific research in the schools of different directions. Are differences between the concepts imitation, invention and innovation. Formulated author's definition of the definition of «innovation

EVOLUTION OFDEFINITIONS «innovation» in the theory ofeconomic schools

Annоtation. The article describes the process of definition of «Innovation» as an object of scientific research in the schools of different directions. Are differences between the concepts imitation, invention and innovation. Formulated author's definition of the definition of «innovation

OSCILLATOR temporality FACTORS implementation of innovative activity of economic entities

Presents arguments justifying the need of accounting for temporary (temporal) factor in the management of innovation. Given modern interpretation of the innovation process from the standpoint of transdisciplinary scientific approach. The proposed mechanism of formation of the oscillator susceptibility of the entity to innovate

Correction of morphofunctional disturbances arising when modelling Preeclampsia with resveratrol and nicorandil

Preeclampsia is one of the most serious diseases of the second half of pregnancy and is surely amongst the top three causes of maternal mortality. Therefore, the creation of new drugs for preventing and correcting preeclampsia is an urgent tas

Determining the significant input parameters of a forecasting model for material resources of residential construction projects at the investment feasibility assessment stage

Any investor/developer spends considerable time to make a construction decision in analyzing various parameters, such as the building site area, height restrictions, total area, quantity of necessary materials, etc. First of all, this is due to a high level of uncertainty and the complexity of estimating costs for the initial stages of project implementation. The unavailability of detailed design data at the investment justification stage makes it impossible to conduct a sufficiently accurate assessment of the value and period of construction to make highly accurate managerial decisions. However, one of the key issues, namely determining the significant parameters that have the greatest impact on future project-related decisions, has not been studied sufficiently. This article identifies the most significant parameters that impact the future characteristics of residential buildings based on an expert assessment using the a priori ranking method. The reliability of the assessment is confirmed using the coefficient of concordance. A conclusion is provided about their applicability as the input values of a forecasting model that uses machine learning and artificial intelligence to determine various technical and economic characteristics of residential buildings

The effect of humoral factors released by hypoperfused placenta on fetal development

Simulation of hypoperfusion of the right uterine horn in rats on the 14th day of pregnancy resulted in disruption of microcirculation in placentas of the left uterine horn, decrease of fetal weight and length as well as in fetal death after implantation. The obtained data complement the overall understanding of the pathogenesis of preeclampsia and placental insufficiency and create preconditions for development of new areas of creation of effective drugs for treatment and prevention of these pathologie