23 research outputs found
Tridentate Directing Groups Stabilize 6-Membered Palladacycles in Catalytic Alkene Hydrofunctionalization
Removable tridentate directing groups
inspired by pincer ligands
have been designed to stabilize otherwise kinetically and thermodynamically
disfavored 6-membered alkyl palladacycle intermediates. This family
of directing groups enables regioselective remote hydrocarbofunctionalization
of several synthetically useful alkene-containing substrate classes,
including 4-pentenoic acids, allylic alcohols, homoallyl amines, and
bis-homoallylamines, under PdÂ(II) catalysis. In conjunction with previous
findings, we demonstrate regiodivergent hydrofunctionalization of
3-butenoic acid derivatives to afford either Markovnikov or anti-Markovnikov
addition products depending on directing group choice. Preliminary
mechanistic and computational data are presented to support the proposed
catalytic cycle
Bimetallic MOFs (H3O)x[Cu(MF6)(pyrazine)2]·(4 − x)H2O (M = V4+, x = 0; M = Ga3+, x = 1): co-existence of ordered and disordered quantum spins in the V4+ system
The title compounds are bimetallic MOFs containing [Cu(pyz)2]2+ square lattices linked by MF6n− octahedra. In each, only the Cu2+ spins exhibit long-range magnetic order below 3.5 K (M = V4+) and 2.6 K (M = Ga3+). The V4+ spins remain disordered down to 0.5 K
Practical Intermolecular Hydroarylation of Terminal Alkenes via Reductive Heck Coupling
The hydroarylation of alkenes is an attractive approach to construct carbon–carbon (C–C) bonds from abundant and structurally diverse starting materials. Herein we report a palladium-catalyzed reductive Heck hydroarylation of unactivated and heteroatom-substituted terminal alkenes with an array of (hetero)aryl iodides. The reaction is anti-Markovnikov selective and tolerates a wide variety of functional groups on both the alkene and (hetero)aryl coupling partners. Additionally, applications of this method to complex molecule diversifications were demonstrated. Deuterium-labeling experiments are consistent with a mechanism in which the key alkylpalladium(II) intermediate is intercepted with formate and undergoes a decarboxylation/C–H reductive elimination cascade to afford the saturated product and turn over the cycle. <br /
Practical Intermolecular Hydroarylation of Terminal Alkenes via Reductive Heck Coupling
The hydroarylation of alkenes is an attractive approach to construct carbon–carbon (C–C) bonds from abundant and structurally diverse starting materials. Herein we report a palladium-catalyzed reductive Heck hydroarylation of unactivated and heteroatom-substituted terminal alkenes with an array of (hetero)aryl iodides. The reaction is anti-Markovnikov selective and tolerates a wide variety of functional groups on both the alkene and (hetero)aryl coupling partners. Additionally, applications of this method to complex molecule diversifications were demonstrated. Deuterium-labeling experiments are consistent with a mechanism in which the key alkylpalladium(II) intermediate is intercepted with formate and undergoes a decarboxylation/C–H reductive elimination cascade to afford the saturated product and turn over the cycle. <br
Catalytic, Regioselective Hydrocarbofunctionalization of Unactivated Alkenes with Diverse C–H Nucleophiles
Reactions
that forge carbon–carbon (C–C) bonds are
the bedrock of organic synthesis, widely used across the chemical
sciences. We report a transformation that enables C–C bonds
to be constructed from two classes of commonly available starting
materials, alkenes and carbon–hydrogen (C–H) bonds.
The reaction employs a palladiumÂ(II) catalyst and utilizes a removable
directing group to both control the regioselectivity of carbopalladation
and enable subsequent protodepalladation. A wide range of alkenes
and C–H nucleophiles, including 1,3-dicarbonyls, aryl carbonyls,
and electron-rich aromatics, are viable reaction partners, allowing
Michael-type reactivity to be expanded beyond α,β-unsaturated
carbonyl compounds to unactivated alkenes. Applications of this transformation in drug
diversification and natural product total synthesis are described.
Stoichiometric studies support each of the proposed steps in the catalytic
cycle
Directed, Regiocontrolled Hydroamination of Unactivated Alkenes via Protodepalladation
A directed, regiocontrolled
hydroamination of unactivated terminal
and internal alkenes is reported. The reaction is catalyzed by palladiumÂ(II)
acetate and is compatible with a variety of nitrogen nucleophiles.
A removable bidentate directing group is used to control the regiochemistry,
prevent β-hydride elimination, and stabilize the nucleopalladated
intermediate, facilitating a protodepalladation event. This method
affords highly functionalized γ-amino acids in good yields with
high regioselectivity
Top-down and bottom-up controls on southern New England salt marsh crab populations
Southern New England salt marsh vegetation and habitats are changing rapidly in response to sea-level rise. At the same time, fiddler crab (Uca spp.) distributions have expanded and purple marsh crab (Sesarma reticulatum) grazing on creekbank vegetation has increased. Sea-level rise and reduced predation pressure drive these changing crab populations but most studies focus on one species; there is a need for community-level assessments of impacts from multiple crab species. There is also a need to identify additional factors that can affect crab populations. We sampled crabs and environmental parameters in four Rhode Island salt marshes in 2014 and compiled existing data to quantify trends in crab abundance and multiple factors that potentially affect crabs. Crab communities were dominated by fiddler and green crabs (Carcinus maenas); S. reticulatum was much less abundant. Burrow sizes suggest that Uca is responsible for most burrows. On the marsh platform, burrows and Carcinus abundance were negatively correlated with elevation, soil moisture, and soil percent organic matter and positively correlated with soil bulk density. Uca abundance was negatively correlated with Spartina patens cover and height and positively correlated with Spartina alterniflora cover and soil shear strength. Creekbank burrow density increased dramatically between 1998 and 2016. During the same time, fishing effort and the abundance of birds that prey on crabs decreased, and water levels increased. Unlike in other southern New England marshes where recreational overfishing is hypothesized to drive increasing marsh crab abundance, we propose that changes in crab abundance were likely unrelated to recreational finfish over-harvest; instead, they better track sea-level rise and changing abundances of alternate predators, such as birds. We predict that marsh crab abundance will continue to expand with ongoing sea-level rise, at least until inundation thresholds for crab survival are exceeded
N-alkylation of 2-pyridone derivatives via palladium(II)-catalyzed directed alkene hydroamination
Affinity Mesh Screen Materials for Selective Extraction and Analysis of Antibiotics Using Transmission Mode Desorption Electrospray Ionization Mass Spectrometry
The extraction of active compounds
from natural sources has shown
to be an effective approach to drug discovery. However, the isolation
and identification of natural products from complex extracts can be
an arduous task. A novel approach to drug discovery is presented through
the use of polymer screens functionalized with an l-lysine-d-alanine-d-alanine (Kaa) peptide to create new affinity
capture mesh screen materials. The Kaa sequence is a well-characterized
specific binding site for antibiotics that inhibit cell wall synthesis
in Gram-positive bacteria. The detailed synthesis and characterization
of these novel screen materials are presented in this work. Polypropylene
mesh screens were first coated with a polyÂ(acrylic acid) film by pulsed
plasma polymerization. The synthesized Kaa peptide was then covalently
attached to carboxylic acid groups through a condensation reaction.
An analysis of captured compounds was performed in a rapid fashion
with transmission-mode desorption electrospray ionization (TM-DESI)
mass spectrometry. A proof of principle was demonstrated to show the
ability of the novel affinity capture materials to select for a macrocyclic
antibiotic, vancomycin, over a negative control compound, spectinomycin.
With further development, this method may provide a rapid screening
technique for new antibacterial compounds, for example, those extracted
from natural product sources having a limited supply. Here, we show
that the screen can capture vancomycin preferentially over spectinomycin
in a spiked extract of tea leaves